Christian Brix Folsted Andersen


The research group studies the functional and structural properties of transport across biological membranes. In particular, how membrane-associated receptors recognize and internalize ligands by endocytosis. Current research is focused on the hemoglobin scavenging system, where free hemoglobin is removed from the blood stream in order to prevent oxidative tissue damage. The two major components of the hemoglobin scavenging system are the plasma protein haptoglobin and the macrophage receptor CD163. The goal of our research is to characterize the structure and function of these two proteins and show how they mediate hemoglobin clearance in conjunction. In addition, we also study the role of haptoglobin in human immunity against trypanosome parasites and how haptoglobin may affect cholesterol transport.

Research interests

  • Hemoglobin scavenging
  • Trypanosome infections
  • High-density lipoprotein (HDL) particles


  • Recombinant expression of proteins (bacteria, yeast, mammalian cells).
  • Purification of proteins from recombinant or natural sources (blood, tissues, acites) by chromatography.
  • Analysis of protein-protein interactions (SPR, ITC, pull-down experiments)
  • Functional studies (mutagenesis, cellular uptake)
  • Structural analysis of macromolecular assemblies (light scattering, small-angle x-ray scattering)
  • High-resolution structure determination (x-ray crystallography)

Collaborators and centres

  • Søren K. Moestrup, Department of Biomedicine, Aarhus University
  • Ebba Nexø, Department of Clinical Biochemistry, Aarhus University Hospital
  • Jan Skov Pedersen, Department of Chemistry, Aarhus University
  • Gregers R. Andersen, Department of Molecular Biology and Genetics, Aarhus University
  • Stefan Raunser, Max Planck Institute of Molecular Physiology, Dortmund, Germany
  • Hans-Petter Hersleth, Department of Molecular Biosciences, University of Oslo, Norway
  • Morten S. Nielsen, Department of Biomedicine, Aarhus University
  • MEMBRANES (Research Excellence Center at Aarhus University)

Group leader

Lars Aagaard

Associate professor
H bldg. 1240, 233
P +4587167769
P +4529903699


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