Sebastian Frische


The expression and role of AKAP-KL in collecting duct intercalated cells.

Localization of E3 ubiquitin ligase Cul5 in the kidney.

The role of Cl- for the adaptation of collecting duct intercalated cells to increased acid excretion.

NH4+ excretion and renal acid/base regulation in Li-intoxication.

Research interests

  • Membrane transporters and signaling systems involved in acid/base regulation.
  • The interaction between renal regulation of NaCl and acid/base balance.
  • Paracrine signaling systems in the kidney.
  • Membrane proteins and regulation systems involved in epithelial transport.
  • Biology of gasses.
  • In vivo microscopy.


  • Animal experiments.
  • Light- and laserconfocal- and electron-microscopy.
  • Immunohistochemistry and immunoelectron microscopy.
  • Analysis of ul-samples of blood and urine by ion-chromatography.

Collaborators and centres

Collaborative ongoing projects with the following researchers at Dept of Biomedicine:

  • Søren Nielsen
  • Jeppe Prætorius
  • Helle Damkier
  • Ole Fejerskov
  • Birgitte Mønster Christensen
  • Erik Ernst
  • Morten Skovgaard
  • Mark West

Numerous other collaborations with researchers at other AU Departments and internationally.

Research group members

Group leader

Sebastian Frische

Associate professor
H bldg. 1233, 231
P +4587168291
P +4524765334


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