Morten Skovgaard Jensen

Research

The main focus in my laboratory is to investigate synaptic plasticity and its relation to learning and memory processes in brain. We focus on the fundamental mechanisms for activity dependent changes in excitatory synapstic transmission and the modulation of plasticity by other transmitter system. We investigate mechanisms responsible for the development of cognitive deficits in Alzheimer’s disease and therapeutic approaches aimed to counteract the disease.

Research interests

  • Synaptic plasticity:Mechanism of short-term potentiation (STP) and long term potentiation(LTP). Pharmacology of the excitatory synaptic transmission. Information decoding of synaptic signals
  • Neuroanatomy: Morphological changes of synapses and nerve cells caused by beta-Amyloid in the central nervous system
  • Behavioural neuroscience: Learning and memory deficits in transgenic models of Alzheimer’s disease.
  • Neuro-degenerative disorder:Changes of synaptic plasticity in mice models of Alzheimer’s disease, modulation of synaptic function by beta-amyloid.

Methodologies

  • Electrophysiology: Intracellular and extracellular recordings in rodent hippocampus slices
  • Behavior: Characterization of spatial and taste memories on mice and rats
  • Immunohistology: beta-amyloid, synapses and nerve cells
  • Protein chemistry: Aggregation of beta-amyloid

Collaborators and centres

  • Prof. Mark J. West, Aarhus University
  • Ass Prof. Agnete Larsen, Aarhus University
  • Ove Wiborg, Institut for Klinisk Medicin - Center for psykiatrisk forskning
  • Gregers Wegener, Institut for Klinisk Medicin - Center for psykiatrisk forskning
  • Prof. Daniel Ottesen, I-Nano, Aarhus Universitet
  • Prof. Bente Findsen, Odense Universitet.
  • Leticia Ramírez-Lugo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México (UNAM).
  • Prof. B. Noyan. University of Bursa, Tyrkiet
  • NeuroCampus, Aarhus Universitet
  • MRC Centre for Synaptic Plasticity, University of Bristol, UK

Research group members

Typically, I supervise 2-3 research students

Group leader

Publications

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