Yasser A. Mahmmoud


We are interested in purification, mechanism, and regulation of P-type ATPases. Generally we are optimizing methods for purification and analysis of P-type ATPases from different animal models. This work provides a significant scaffold to related structural and molecular biology investigations. Our main focus is currently attracted to the modulation by natural drugs as well as non transport functions of P-type ATPases. In addition, we are interested in posttranslational modification of molecules interacting with the catalytic subunit of the sodium pump, especially under conditions of oxidative stress.

Research interests

  • Regulation of Na,K-ATPase by association with FXYD proteins.
  • How active constituents in medicinal plants sustain a given pharmacological effect?
  • Uncoupling of sarcoplasmic reticulum Ca2+-ATPase
  • Non-transport function(s) of Na,K-ATPase. Does inhibition of Na,K-ATPase play a role in blood pressure regulation?


  • Langendorff perfusion
  • Protein chemistry and Biochemical assays
  • Membrane protein purification
  • Fluorescence spectroscopy

Collaborators and centres

  • Flemming Cornelius, Dept. Biomedicine, University of Aarhus.
  • Michael Shattock, Cardiovascular division, King’s College, London.
  • Søren Brøgger Christensen, Dept. Medicinal Chemistry, University of Copenhagen.
  • Michael Gaster, Dept. Pathology and endocrinology, University hospital of Odense.
  • Vladimir Matchkov, Dept. Biomedicine, University of Aarhus.

Research group members

  •  Anne Lillevang, technician  

Group leader


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