Søren Riis Paludan

Research

The research goal of this laboratory is to understand how the innate immune system recognizes virus infections, how this leads to an immune response against infection, and how viruses seek to evade/modify this response. With a focus on herpesviruses, we aim to provide new basic knowledge on how the innate immune system works and interacts with viruses, and how this impacts on the pathogenesis of viral infections. Such work may lead to better understanding of viral diseases and could have implications for future development of improved vaccines, antiviral therapeutics, and diagnostic tools.

Research interests

  • Detection of viruses by the innate immune system.
  • Signal transduction and gene expression in innate immune responses to infection.
  • Interactions between the innate immune system and basic cellular processes.
  • Viral mechanisms of innate immune evasion.
  • Mechanisms of host defense in animal models for human diseases.

Methodologies

  • Cell culture and differentiation of primary cells
  • Animal infection models
  • T cell and NK cell cytotoxicity assays
  • Methods in virology
  • ELISA
  • Luminex 
  • Type I IFN bioassay
  • Western Blotting
  • Oligonucleotide pull-down assays
  • Flow cytometry
  • Confocal laser scanning microscopy
  • Immunohistochemistry
  • RNAi
  • RNA and DNA isolation
  • Real-time PCR

Collaborators and centres

Søren Riis Paludan is leader of the Aarhus University Research Foundation Pilot Center “Aarhus Research Center for Innate Immunology”

Key collaborators

  • Professor Andrew G Bowie, PhD (Trinity College Dublin, Ireland)
  • Associate professor Katherine A Fitzgerald, PhD (University of Massachusetts, USA)
  • Professor MD, DMSc Allan Randrup Thomsen (Copenhagen University, Denmark)
  • Associate professor Rune Hartmann, PhD (Aarhus University, Denmark)
  • Associate professor D. Vet. Med. Frederik Dagnæs-Hansen, PhD (Aarhus University, Denmark)
  • Senior resident MD, DMSc Trine Mogensen, PhD (Aarhus University Hospital – Skejby, Denmark)

Research group members

The Søren Riis Paludan group

Group leader

Søren Riis Paludan

Professor
M
H bldg. 1242, 515
P +4587167843
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Publications

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