Jørgen Rungby

Research

Center for pharmacotherapy: Pharmacological and toxicological studies in chronic degenerative and metabolic diseases: Cell to population

Explaining genetic, cellular, metabolic and epidemiological features important for monitoring current and developing new pharmacotherapies for a number of chronic diseases is the major focus of the group. Currently, we are focused on type 2 diabetes and a number of neurodegenerative processes, including Alzheimer’s disease. We employ a wide range of methods, both in vivo studies in humans and animals and in vitro studies, including genetic analyses, metabolic studies, neuroimaging and epidemiology. Our studies are conducted in collaborations with national and international partners, including pharmaceutical companies. The group is represented in the steering committees of two major health research programs, the LuCamp project (www.lucamp.org) and the DD2 project (www.DD2.nu).

Research interests

  • Pharmacology
  • Diabetes
  • Epidemiology
  • Neurodegeneration

For detailed information, please see Center for Pharmacology & Pharmacotherapy

Methodologies

  • Population-based pharmaco-epidemiological studies
  • Clinical studies in healthy subjects or patients with degenerative, endocrine or metabolic diseases, e.g. type 1 or type 2 diabetes, Alzheimer’s disease, patients with partial or total GH deficiency: Pharmacokinetic studies, metabolic studies using clamp techniques, imaging studies using PET (glucose or PiB) and MR, studies of tissue perfusion
  • Animal models of neurodegenerative diseases and conditions related to altered cognitive functions i.e. Alzheimer´s Disease, Multiple Sclerosis, stereotaxtic and cryobased traumatic brain injury and diabetes
  • Cellular studies on immune cells, neurons, alpha- and beta cells, glia cells
  • Studies on isolated Islets of Langerhans
  • Genetic and histopathological analyses of cell death mechanisms and inflammatory responses
  • Autometallographic detection of exogenous  and endogenous metals
  • Immunohistochemistry, microdissection and stereology
  • PCR based studies of gene expression, protein analyses by western blotting
  • ELISA based studies of insulin content and insulin secretion along with other hormones

Collaborators

  • University Hospital of Copenhagen, Laboratory of Reproductive Biology, Professor Claus Yding
  • University of Copenhagen, Department of Neurobiology, Professor Albert Gjedde, numerous collaborators at The Centre for Metabolic Research
  • The National Research Centre for the Working Environment, Copenhagen, Professors Ulla Vogel and Håkan Wallin
  • University of Greiswald, Professor Fritz Scholz
  • Zinc-UK, zinc-uk.org
  • University of Grenoble, Mellitech, PhD Fabrice Chimienti
  • University of Toronto, Department of Physiology, Professor Mike Wheeler
  • University of Melbourne and Harvard Medical School, Cooperative Research Centre for Mental Health, Professor Ashley Bush
  • Clinical Medicine, Aarhus University, numerous collaborators
  • Department of Biomedicine, Aarhus University, numerous collaborators
  • Dr Thomas Hyde, The Lieber Institute
  • Professor Bente Pakkenberg, Bispebjerg Hospital.

Research group members

Publications

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