Mogens Andreasen

Group Leader

Mogens Andreasen
Associate Professor, MD, DMSc
More information  

RESEARCH
The laboratory started in 2001 and has three main focus areas: (i) Understanding the principles of interneuronal communications and cortical network behavior, ii) understanding the pathophysiological aspects of ictogenesis, iii) development of new therapeutic strategies for the treatment of epiletic seizures. The studies are based on in vitro model systems in which the functional properties of individual neurons or networks of neurons are investigated using electrophysiological recording techniques and histochemical analysis. We have developed an in vitro model for epileptic seizure activity which gives us the unique opportunity not only to study ictogenesis, but also to explore new strategies for the treatment of seizure activity.

RESEARCH INTERESTS
Interneuronal communication: Investigation of the principles for transfer and integration of signals from one neuron to another. 

Dendritic signal integration: Investigation of dendritic electrophysiological and integrative properties.

Neuronal network behavior: Investigation of the principles for synchronization of neuronal network with the focus on oscillatory behavior in the theta frequency band.

Neuronal network dysfunction: Investigation of the pathophysiological aspects of ictogenesis.

Astrocytic dysfunction: Investigation of the impact of astrocytic dysfunction in relationship to ictogenesis. 

Antiepileptic strategies: Investigation of new strategies for the treatment of epilepsy.   

METHODOLOGIES
Electrophysiological recording techniques: Intra- and extra-cellular recordings from individual and groups of neurons, respectively.

Electrical field stimulation

Histochemical analysis

In vitro animal models

COLLABORATORS & Centers

  • Professor John J. Hablitz, Department of Neurobiology, University of Alabama, USA.
  • Professor Dan Klærke, Department of Physiology and Biochemistry, University of Copenhagen, Denmark.

RESEARCH GROUP MEMBERS
Steen Nedergaard, Associate Professor; Bertha Beck P. Mortensen, technician, 1 Master student, 1 Bachelor student.



 

 

                                                          

Henvendelse om denne sides indhold: 
Revideret 03.08.2016