Martin Roelsgaard Jakobsen

Martin Roelsgaard Jakobsen
Postdoc, PhD, MSc (Molecular biology)
More information

RESEARCH
Human immunodeficiency virus (HIV)-1 is one of the major viral infections where research suggests a strong linkage between the innate immune response and viral pathogenesis. More knowledge on this may enable better treatment, vaccines and possibly cure of HIV-1 infection. Our current understanding of the way HIV-1 infects human immune cells without provoking an immunological respond is still incomplete and many of the key questions remain unanswered. In my research I focus on the early steps of HIV-1 infection, following fusion and reverse transcription as this seem as good candidates for being involved in both recognition and evasion.

It’s the ambition that my projects will add new knowledge to the interplay between the early step of viral infection and how this generate an innate immune response in macrophages – one of the primary cell types that HIV infect. I aim to describe new PRRs as well as defining strong HIV PAMPs, and the mechanism for how IFN is regulated by HIV. The perspective is that my work will have impact on a better development of medication and strategies to boost the host immune system to battle the HIV infection.

RESEARCH INTERESTS
Detection of viruses by the innate immune system.

Signal transduction and gene expression in innate immune responses to infection.

Interactions between the innate immune system and basic cellular processes.

Viral mechanisms of innate immune evasion.

Mapping viral protein – host protein interactions .

METHODOLOGIES
Laboratory work in biosafety GMO2 level II and III
Cell culture and differentiation of primary cells
ELISA
Luminex
Western Blotting
qRT-PCR
RNA and DNA isolation
Cloning
HIV viral genomics
shRNA lentiviral transfection assays
RNAi
Confocal Laser Scanning Microscopy
Viral Infection assays
Cell-cell fusion assays
Counterflow Centrifugal Elutriation
Flow Cytometry
Primary Human Macrophage and CD4+ T cell growth assay
Amaxa Nucleofection
DNA sequencing

Centers

  • Working in Professor Søren Riis Paludan Group at Biomedicine, Aarhus University.
  • Participant in Aarhus University Research Foundation Pilot Center “Aarhus Research Center for Innate Immunology”.

Collaborators

  • Associate professor Paul Gorry, PhD (Burnet Institute, Melbourne, Australia)
  • Associate professor Stuart Turville, PhD (Kirby Institute, University of New South Wales, Australia)
  • Associate professor Jacob Giehm Mikkelsen, PhD (Aarhus University, Denmark)
  • Senior resident, MD, DMSc Trine Mogensen, PhD (Aarhus University Hospital Skejby, Denmark)
  • Professor Marianne Hokland, PhD (Aarhus University, Denmark)
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Revideret 03.08.2016