Anders Lade Nielsen Lab

Group Leader

Anders Lade Nielsen
Professor MSO
More information

RESEARCH
An important biomedical question is how the human organism with its billions of cells with a variety of different functions is generated from the single fertilized cell. This information is captured within the DNA genome which is the same in nearly all cells. However, the reading of the genome is different in individual cells. The mechanism which allows such a different reading is abbreviated epigenetics, meaning the layer above the normal genetic information. Epigenetic control mechanisms are essential for the development and maintenance of complex organisms. Examples for epigenetics are regulation of transcription at the chromatin template as well as miRNA mediated regulation. Deregulation of epigenetic mechanisms is consequently involved in a variety of human disorders. The main focus of the laboratory is to question how epigenetics is involved in normal developmental processes and in human cancer and neurological disorders.

RESEARCH INTERESTS
The laboratory currently addresses a series of different projects concerning epigenetics and human diseases. The titles for the main projects are listed below. For more detailed information concerning the individual project and for vacant positions please contact Anders Lade Nielsen.

Epigenetics in neuro-psychiatric and neuro-degenerative diseases

Epigenetic regulation and de-regulation in cancer

Pig models for human diseases and epigenetics

Zinc finger proteins, repression of genes and viruses, and epigenetics

Intermediate filaments: genetics, epigenetics, and functions

RNA processing and localization

METHODOLOGIES
Cell culture analysis, immunofluorescence microscopy, molecular cloning, immunoprecipitation, microarray analysis, next-generation sequencing, siRNA, miRNA, real time PCR, chromatin immunoprecipitation (ChIP), DNA-methylation assays, Boyden Chamber assay, Direct RNA sequencing, single molecule FISH.

COLLABORATORS & Centers
Collaboration with research groups at the Department of Biomedicine, research groups in other Departments from Aarhus University, and external research groups.

RESEARCH GROUP MEMBERS
Rune Thomsen, Research Assistant, PhD; Jenny Blechingberg, PhD student; Christina Ane Elisabeth Sølvsten, PhD student; technician Tina Fuglsang Daugaard.

Moreover, the group co-supervises a number of PhD students, master students and bachelor students.

                                                          

Henvendelse om denne sides indhold: 
Revideret 03.08.2016