Søren Riis Paludan

Group Leader

Søren Riis Paludan
Professor
More information 

RESEARCH
The research goal of this laboratory is to understand how the innate immune system recognizes virus infections, how this leads to an immune response against infection, and how viruses seek to evade/modify this response. With a focus on herpesviruses, we aim to provide new basic knowledge on how the innate immune system works and interacts with viruses, and how this impacts on the pathogenesis of viral infections. Such work may lead to better understanding of viral diseases and could have implications for future development of improved vaccines, antiviral therapeutics, and diagnostic tools.

RESEARCH INTERESTS
Detection of viruses by the innate immune system.

Signal transduction and gene expression in innate immune responses to infection.

Interactions between the innate immune system and basic cellular processes.

Viral mechanisms of innate immune evasion.

Mechanisms of host defense in animal models for human diseases.

METHODOLOGIES
Cell culture and differentiation of primary cells

Animal infection models

T cell and NK cell cytotoxicity assays

Methods in virology

ELISA

Luminex 

Type I IFN bioassay

Western Blotting

Oligonucleotide pull-down assays

Flow cytometry

Confocal laser scanning microscopy

Immunohistochemistry

RNAi

RNA and DNA isolation

Real-time PCR

COLLABORATORS & Centers

Søren Riis Paludan is leader of the Aarhus University Research Foundation Pilot Center “Aarhus Research Center for Innate Immunology”

Key collaborators

  • Professor Andrew G Bowie, PhD (Trinity College Dublin, Ireland)
  • Associate professor Katherine A Fitzgerald, PhD (University of Massachusetts, USA)
  • Professor MD, DMSc Allan Randrup Thomsen (Copenhagen University, Denmark)
  • Associate professor Rune Hartmann, PhD (Aarhus University, Denmark)
  • Associate professor D. Vet. Med. Frederik Dagnæs-Hansen, PhD (Aarhus University, Denmark)
  • Senior resident MD, DMSc Trine Mogensen, PhD (Aarhus University Hospital – Skejby, Denmark)

Research Group Members

The Søren Riis Paludan group

Kristy A Horan, PhD, postdoc

Martin R Jakobsen, PhD, postdoc

Christian K Holm, PhD, postdoc

Line S Reinert, PhD student

Søren B Jensen, PhD student

Marie B Iversen, Phd student

Srikanth Chiliveru, PhD student

Kirsten S. Petersen, technician

Henvendelse om denne sides indhold: 
Revideret 03.08.2016