Mannose 6 Phosphate Receptor as a Target for Disease-modifying therapies in Parkinson's Disease

Parkinson’s disease (PD) is characterized by intracellular protein depositions known as Lewy bodies, mainly containing α-synuclein protein. Deregulation of α-synuclein and impaired neuronal trafficking, are largely considered as one of the early key factors contributing to PD. We looked at the  syn trafficking from mice and human models of PD, by employing new-sophisticated cell microscopy technologies, and we found a no-previously described explanation for  syn deregulation in neurons.  Remarkably, we identify two crucial actors of these events and we plan to start a screening in animal models before and in human samples later, testing the ambitious hypothesis to use them as prognostic or diagnostic tools of the disease.

Bevillings-ID: DFF – 4004-00330

Projektet består af følgende 3 delprojekter

  • Analyze the neuronal trafficking of MPR and its adaptors from WT and ASO neurons.
  • Examine the location, movement and kinetic of secretion of these target protein(s) in living cells.
  • Modify the expression or the trafficking of target protein(s) to evaluate if the neuronal network is rescued.

Collaborators

  • Morten S Nielsen
  • Pekka Kallunki
  • Peder Madsen
  • Oddmund Bakke 

Bevillingsmodtager
Ph.d. Carmela Matrone
Institut for Biomedicin