Publications

Birn H, Verroust PJ, Nexo E, Hager H, Jacobsen C, Christensen EI and Moestrup SK. Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein. J Biol Chem 272: 26497-26504, 1997.

Graversen JH, Lorentsen RH, Jacobsen C, Moestrup SK, Sigurskjold BW, Thogersen HC and Etzerodt M. The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine. J Biol Chem 273: 29241-29246, 1998.

Hartmann R, Norby PL, Martensen PM, Jorgensen P, James MC, Jacobsen C, Moestrup SK, Clemens MJ and Justesen J. Activation of 2'-5' oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers. J Biol Chem 273: 3236-3246, 1998.

Kozyraki R, Kristiansen M, Silahtaroglu A, Hansen C, Jacobsen C, Tommerup N, Verroust PJ and Moestrup SK. The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region [published erratum appears in Blood 1998 Oct 1;92(7):2608]. Blood 91: 3593-3600, 1998.

Moestrup SK, Schousboe I, Jacobsen C, Leheste JR, Christensen EI and Willnow TE. beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I- phospholipid complex harbor a recognition site for the endocytic receptor megalin. J Clin Invest 102: 902-909, 1998.

Tauris J, Ellgaard L, Jacobsen C, Nielsen MS, Madsen P, Thogersen HC, Gliemann J, Petersen CM and Moestrup SK. The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin. FEBS Lett 429: 27-30, 1998.

Christensen EI, Moskaug JO, Vorum H, Jacobsen C, Gundersen TE, Nykjaer A, Blomhoff R, Willnow TE and Moestrup SK. Evidence for an essential role of megalin in transepithelial transport of retinol. J Am Soc Nephrol 10: 685-695, 1999.

Hilpert J, Nykjaer A, Jacobsen C, Wallukat G, Nielsen R, Moestrup SK, Haller H, Luft FC, Christensen EI and Willnow TE. Megalin antagonizes activation of the parathyroid hormone receptor. J Biol Chem 274: 5620-5625, 1999.

Kozyraki R, Fyfe J, Kristiansen M, Gerdes C, Jacobsen C, Cui S, Christensen EI, Aminoff M, de lC, Krahe R, Verroust PJ and Moestrup SK. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med 5: 656-661, 1999.

Kristiansen M, Kozyraki R, Jacobsen C, Nexo E, Verroust PJ and Moestrup SK. Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding [In Process Citation]. J Biol Chem 274: 20540-20544, 1999.

Leheste JR, Rolinski B, Vorum H, Hilpert J, Nykjaer A, Jacobsen C, Aucouturier P, Moskaug J, Otto A, Christensen EI and Willnow TE. Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria. Am J Pathol 155: 1361-1370, 1999.

Munck PC, Nielsen MS, Jacobsen C, Tauris J, Jacobsen L, Gliemann J, Moestrup SK and Madsen P. Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. EMBO J 18: 595-604, 1999.

Nielsen MS, Jacobsen C, Olivecrona G, Gliemann J and Petersen CM. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem 274: 8832-8836, 1999.

Niemeier A, Willnow T, Dieplinger H, Jacobsen C, Meyer N, Hilpert J and Beisiegel U. Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro. Arterioscler Thromb Vasc Biol 19: 552-561, 1999.

Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, Melsen F, Christensen EI and Willnow TE. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 96: 507-515, 1999.

Andersen OM, Christensen LL, Christensen PA, Sorensen ES, Jacobsen C, Moestrup SK, Etzerodt M and Thogersen HC. Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP). A conserved acidic residue in the complement-type repeats is important for recognition of RAP. J Biol Chem 2000 Jul 14 ;275 (28 ):21017 -24 275: 21017-21024, 2000.

Andersen OM, Christensen PA, Christensen LL, Jacobsen C, Moestrup SK, Etzerodt M and Thogersen HC. Specific binding of alpha-macroglobulin to complement-type repeat CR4 of the low-density lipoprotein receptor-related protein. Biochemistry 2000 Sep 5 ;39 (35 ):10627 -33 39: 10627-10633, 2000.

Birn H, Fyfe JC, Jacobsen C, Mounier F, Verroust PJ, Orskov H, Willnow TE, Moestrup SK and Christensen EI. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 2000 May ;105 (10 ):1353 -61 105: 1353-1361, 2000.

Chan WL, Shaw PC, Tam SC, Jacobsen C, Gliemann J and Nielsen MS. Trichosanthin interacts with and enters cells via LDL receptor family members. Biochem Biophys Res Commun 2000 Apr 13 ;270 (2 ):453 -7 270: 453-457, 2000.

Graversen JH, Jacobsen C, Sigurskjold BW, Lorentsen RH, Moestrup SK, Thogersen HC and Etzerodt M. Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. GRAFTING NOVEL KRINGLE AFFINITY ONTO THE TETRANECTIN LECTIN SCAFFOLD. J Biol Chem 2000 Dec 1 ;275 (48 ):37390 -6 275: 37390-37396, 2000.

Kristiansen M, Aminoff M, Jacobsen C, de La CA, Krahe R, Verroust PJ and Moestrup SK. Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin. Blood 2000 Jul 15 ;96 (2 ):405 -9 96: 405-409, 2000.

Sousa MM, Norden AG, Jacobsen C, Willnow TE, Christensen EI, Thakker RV, Verroust PJ, Moestrup SK and Saraiva MJ. Evidence for the role of megalin in renal uptake of transthyretin. J Biol Chem 2000 Dec 8 ;275 (49 ):38176 -81 275: 38176-38181, 2000.

Vorum H, Jacobsen C and Honore B. Calumenin interacts with serum amyloid P component. FEBS Lett 2000 Jan 14 ;465 (2 -3 ):129 -34 465: 129-134, 2000.

Andersen OM, Petersen HH, Jacobsen C, Moestrup SK, Etzerodt M, Andreasen PA and Thogersen HC. Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein. Biochemical Journal 357: 289-296, 2001.

Andersen OM, Schwarz FP, Eisenstein E, Jacobsen C, Moestrup SK, Etzerodt M and Thogersen HC. Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP. Biochemistry 40: 15408-15417, 2001.

Burmeister R, Boe IM, Nykjaer A, Jacobsen C, Moestrup SK, Verroust P, Christensen EI, Lund J and Willnow TE. A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney. Journal of Biological Chemistry 276: 13295-13301, 2001.

Jacobsen L, Madsen P, Jacobsen C, Nielsen MS, Gliemann J and Petersen CM. Activation and functional characterization of the mosaic receptor SorLA/LR11. Journal of Biological Chemistry 276: 22788-22796, 2001.

Kozyraki R, Fyfe J, Verroust PJ, Jacobsen C, Dautry-Varsat A, Gburek J, Willnow TE, Christensen EI and Moestrup SK. Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Proceedings of the National Academy of Sciences of the United States of America 98: 12491-12496, 2001.

Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK and Moestrup SK. Identification of the haemoglobin scavenger receptor. Nature 2001 Jan 11 ;409 (6817 ):198 -201 409: 198-201, 2001.

Nykjaer A, Fyfe JC, Kozyraki R, Leheste JR, Jacobsen C, Nielsen MS, Verroust PJ, Aminoff M, de la Chapelle A, Moestrup SK, Ray R, Gliemann J, Willnow TE and Christensen EI. Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3. Proceedings of the National Academy of Sciences of the United States of America 98: 13895-13900, 2001.

Birn H, Zhai XY, Holm J, Hansen SI, Jacobsen C, Moestrup SK and Christensen EI. Megalin binds and mediates cellular uptake of the folate binding protein. Journal of the American Society of Nephrology 13: 486A, 2002.

Caterer NR, Graversen JH, Jacobsen C, Moestrup SK, Sigurskjold BW, Etzerodt M and Thogersen HC. Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL. Biol Chem 383: 1743-1750, 2002.

Gburek J, Verroust PJ, Willnow TE, Fyfe JC, Nowacki W, Jacobsen C, Moestrup SK and Christensen EI. Megalin and cubilin are Endocytic receptors involved in renal clearance of hemoglobin. Journal of the American Society of Nephrology 13: 423-430, 2002.

Schmitz C, Hilpert J, Jacobsen C, Boensch C, Christensen EI, Luft FC and Willnow TE. Megalin deficiency offers protection from renal aminoglycoside accumulation. Journal of Biological Chemistry 277: 618-622, 2002.

Conticello SG, Kowalsman ND, Jacobsen C, Yudkovsky G, Sato K, Elazar Z, Petersen CM, Aronheim A and Fainzilber M. The prodomain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors. J Biol Chem 278: 26311-26314, 2003.

Gburek J, Birn H, Verroust PJ, Goj B, Jacobsen C, Moestrup SK, Willnow TE and Christensen EI. Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.  Am J Physiol Renal Physiol 285: F451-F458, 2003.

Hermey G, Keat SJ, Madsen P, Jacobsen C, Petersen CM and Gliemann J. Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. J Biol Chem 278: 7390-7396, 2003.

Petersen HH, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek AJ and Willnow TE. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci 116: 453-461, 2003.

Gliemann J, Hermey G, Nykjaer A, Petersen CM, Jacobsen C and Andreasen PA. The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand. Biochem J 381: 203-212, 2004.

Horn IR, Nielsen MJ, Madsen M, Jacobsen C, Graversen JH and Moestrup SK. Generation of a haptoglobin-hemoglobin complex-specific antibody blocking the binding of the complex to CD163 (vol 71, pg 289, 2003). European Journal of Haematology 72: 77, 2004.

Jacobsen C and Moestrup SK. Using Biacore technology to characterize receptors for macromolecular complexes. Biacore Journal 4: 13-15, 2004.

Madsen M, Moller HJ, Nielsen MJ, Jacobsen C, Graversen JH, van den BT and Moestrup SK. Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region. J Biol Chem 279: 51561-51567, 2004.

Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL and Petersen CM. Sortilin is essential for proNGF-induced neuronal cell death. Nature 427: 843-848, 2004.

Petersen HH, Hilpert J, Jacobsen C, Lauwers A, Roebroek AJ and Willnow TE. Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. FEBS Lett 565: 23-27, 2004.

Petersen SV, Oury TD, Ostergaard L, Valnickova Z, Wegrzyn J, Thogersen IB, Jacobsen C, Bowler RP, Fattman CL, Crapo JD and Enghild JJ. Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation. J Biol Chem 279: 13705-13710, 2004.

Westergaard UB, Sorensen ES, Hermey G, Nielsen MS, Nykjaer A, Kirkegaard K, Jacobsen C, Gliemann J, Madsen P and Petersen CM. Functional organization of the sortilin Vps10p domain. J Biol Chem 279: 50221-50229, 2004.

Birn H, Zhai XY, Holm J, Hansen SI, Jacobsen C, Christensen EI and Moestrup SK. Megalin binds and mediates cellular internalization of folate binding protein. Febs Journal 272: 4423-4430, 2005.

Hvidberg V, Maniecki MB, Jacobsen C, Hojrup P, Moller HJ and Moestrup SK. Identification of the receptor scavenging hemopexin-heme complexes. Blood 2005.

Hvidberg V, Jacobsen C, Strong RK, Cowland JB, Moestrup SK and Borregaard N. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 579: 773-777, 2005.

Westergaard UB, Kirkegaard K, Sorensen ES, Jacobsen C, Nielsen MS, Petersen CM and Madsen P. SorCS3 does not require propeptide cleavage to bind nerve growth factor. FEBS Lett 579: 1172-1176, 2005.

Sanggaard KW, Sonne-Schmidt CS, Jacobsen C, Thogersen IB, Valnickova Z, Wisniewski HG and Enghild JJ. Evidence for a Two-Step Mechanism Involved in the Formation of Covalent HC.TSG-6 Complexes. Biochemistry 45: 7661-7668, 2006.

Van den Steen PE, Van A, I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, Moestrup SK, Fry S, Royle L, Wormald MR, Wallis R, Rudd PM, Dwek RA and Opdenakker G. The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bio-availability via inhibition and binding to cargo receptors. J Biol Chem 2006.

Acknowledgements

Please acknowledge the Biacore – Molecular Interactions Core Facility, when publishing results obtained using our services, and please advise us about the publication by e-mailing us a link to the publication at biacore.biomed@au.dk.