Duncan, C. J. A.
, Skouboe, M. K., Howarth, S.
, Hollensen, A. K., Chen, R., Børresen, M. L., Thompson, B. J., Stremenova Spegarova, J., Hatton, C. F., Stæger, F. F., Andersen, M. K., Whittaker, J.
, Paludan, S. R., Jørgensen, S. E., Thomsen, M. K., Mikkelsen, J. G., Heilmann, C., Buhas, D., Øbro, N. F.
... Mogensen, T. H. (2022).
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.
The Journal of Experimental Medicine,
219(6), Article e20212427.
https://doi.org/10.1084/jem.20212427
Freytag, M. R.
, Jørgensen, S. E., Thomsen, M. M., Al-Mousawi, A., Hait, A. S.
, Olagnier, D., Bay, J. T., Helleberg, M.
& Mogensen, T. H. (2022).
Postpartum Disseminated Herpes Simplex Virus Type 1 Infection With Hemophagocytic Lymphohistiocytosis and Fulminant Neonatal Herpes Infection.
The Journal of Infectious Diseases,
225(1), 157-162.
https://doi.org/10.1093/infdis/jiab290
Brodin, P., Casari, G., Townsend, L., O’Farrelly, C., Tancevski, I., Löffler-Ragg, J.
, Mogensen, T. H., Casanova, J. L. & The COVID Human Genetic Effort (2022).
Studying severe long COVID to understand post-infectious disorders beyond COVID-19.
Nature Medicine,
28, 879-882.
https://doi.org/10.1038/s41591-022-01766-7
Manry, J., Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Michailidis, E., Hoffmann, H. H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., de Prost, N., Tandjaoui-Lambiotte, Y. ... CoV-Contact Cohort (2022).
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
Proceedings of the National Academy of Sciences,
119(21), Article e2200413119.
https://doi.org/10.1073/pnas.2200413119
Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Manry, J., Michailidis, E., Hoffmann, H. H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., Prost, N. D., Tandjaoui-Lambiotte, Y. ... Imagine COVID Group (2021).
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Science Immunology,
6(62), Article 4340.
https://doi.org/10.1126/sciimmunol.abl4340
Reinert, L. S., Rashidi, A. S., Tran, D. N., Katzilieris-Petras, G., Hvidt, A. K., Gohr, M., Fruhwürth, S., Bodda, C.
, Thomsen, M. K., Vendelbo, M. H., Khan, A. R.
, Hansen, B., Bergström, P., Agholme, L.
, Mogensen, T. H., Christensen, M. H.
, Nyengaard, J. R., Sen, G. C., Zetterberg, H.
... Paludan, S. R. (2021).
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production.
Journal of Clinical Investigation,
131(1), Article e136824.
https://doi.org/10.1172/JCI136824