Jelena Radulovic studies how stressful experiences affect the brain memory circuits, and through stress-related memories influences social and emotional behavior. In addition to her laboratory at AU Department of Biomedicine, she is also leading a research laboratory at the Department of Neuroscience at Albert Einstein College (NY, USA).
Dr. Radulovic’s experiments combine genetic mouse models with molecular, cellular, and circuit manipulations of the extended hippocampal circuit. With these approaches, she aims to advance our knowledge of the neurobiology of stress and identify brain mechanisms that could pose a risk for affective disorders, such as anxiety, depression, post-traumatic stress disorder, and traumatic amnesia.
Dr. Yamawaki is interested in understanding how neuronal circuits produce memory-guided movements. He spent his early career dissecting the local and long-range circuits in motor cortex, focusing on different classes of excitatory projection neurons. More recently, he studied the circuits of retrosplenial cortex (RSC), which are a major afferent of motor cortex and are implicated in contextual memory.
At the Department of Biomedicine, Yamawaki will continue to work on the hippocampal-RSC network and examine how these circuits encode and maintain the stress-related memories and are affected in various disease states. Then, he hopes to look into the type of movements RSC memories have major implications.
Dr. Tanimura is interested in understanding the cellular mechanisms and function of synaptic plasticity in physiological and pathophysiological conditions, using an in vitro electrophysiology and optogenetics as the main tool. In the previous lab at Northwestern University, she examined the role of the cholinergic system in the basal ganglia circuits in the mouse model of Parkinson’s disease (PD). She found a critical role of acetylcholine in abnormally facilitating thalamostriatal connection and consequently disturbing motor learning in PD.
At the Department of Biomedicine, Tanimura will primarily investigate the effect of stress-mediated abnormal neuromodulator release in cortico-hippocampal systems under the stress-related depression-like behavior, using molecular biology, in vitro electrophysiology, in vivo imaging, and behavioral tests.. She also plans to examine how stress may induce neurodegeneration related to diseases such as PD and Alzheimer's Disease.
With training and an MSc. in Clinical Pharmacy (Uni. of Sunderland, UK) followed by an MPhil. in Translational Medicine (Helsinki University, Finland), Islam specialised in systems and circuit neuroscience in his Ph.D. In the PhD training he investigated behavioural effects of heterosynaptic plasticity and the circuitry of innate (and learned) defensive behaviors. Islam will investigate the circuitry that underlies social behaviours in mice and its dynamics relationship with stress, reward and learning. To this end, Islam will use his expertise in in-vivo electrophysiology, optogenetics/chemogenetics, fiber photometry and advanced behavioural testing.
Tim-Simon Burmeister is interested in understanding how short- and long-term molecular dysregulation affects behaviour and their mediating neuronal circuits.
With specialization in the fields of behavioural research and neuropsychopharmacology during his BSc. And MSc. Studies, he focused on the development, validation, and translatability of animal behaviour models by utilizing pharmacological and genetic manipulation.
At the Department of Biomedicine Tim will investigate the mechanisms of social stress-mediated alteration of social memory and the relevant neuronal circuits in an interdisciplinary approach.
By that means, he will combine circuit analysis in addition to optical and chemogenetic manipulation with behavioural research.