• Consulting on experimental design, bioinformatics methods and computational tools.
• Data quality assessment, processing, analysis, visualization and interpretation
  • Next Generation Sequence Analysis (e.g., bulk RNA-Seq, ChIP-Seq, DNA-Seq, scRNA-Seq)
  • DNA analysis (e.g. functional annotation, gene set enrichment/association analysis)
  • RNA Analysis (e.g. expression profiling, target prediction, splicing)
  • Sequence analysis (e.g. variant detection, SNP annotation, transcription factor binding site enrichment)
• Preparation of data sets to submit in public repositories (e.g. GEO, SRA and PRIDE)
• Data mining of published datasets, correlation and integration of results
• Assistance with the preparation of manuscripts, presentations and grant proposals
• Workshops on bioinformatics topics to facilitate data access and analysis

The Bioinformatics Core Facility provides 3 categories of services.

1. Fee for service costumer support/consultancy/data analysis:

2. Scientific collaborations: Requests that require an effort beyond technical assistance/consultancy/analysis of individual data-sets will be set up as a research collaboration. Funding for collaborative research performed by core facility partners must be provided unless otherwise agreed – and will comprise a pre-agreed fixed cost of conducting the research. The result of joint research shall be published with joint authorship.

3. Workshop and lectures will be provided free of charge. Individual training sessions can be booked at a pre-agreed cost.

Initial project meeting is always for free and requests that can be solved within a few working hours are usually free of charge, provided that the core facility has resources available.

For scientific collaborations, we encourage users to include Bioinformatics Core staff as early as possible in the process – and preferably already in the preparation of grant proposals.

You are always free to come by for an initial discussion of your projects. We attempt to keep the core open every Monday 10.30-12.00.

However, we encourage you to call/write first and make an appointment.

Bioinformatics Core Facility
Department of Biomedicine
The Skou Building 1116, room 456
Høegh-Guldbergsgade 10
8000 Aarhus C
Denmark

Please acknowledge the Bioinformatics Core Facility, when publishing results obtained using our services, and please advise us about the publication by e-mailing us a link to the publication at per.q@biomed.au.dk.

• SORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat
  Vanessa Schmidt, Carla Horváth, Hua Dong, Matthias Blüher, Per Qvist, Christian Wolfrum, and Thomas Willnow Journal of Cell Biology, 2021. DOI: 10.1083/jcb.202006058
• Enhanced Production of Mesencephalic Dopaminergic Neurons from Lineage-Restricted Human Undifferentiated Stem Cells
  Muyesier Maimaitili, Muwan Chen, Fabia Febbraro, Noëmie Mermet-Joret, Johanne Lauritsen, Ekin Ucuncu, Ida Hyllen Klæstrup, Per Qvist, Sadegh Nabavi, Marina Romero-Ramos and Mark Denham. Nature Communications. DOI: 10.1038/s41467-023-43471-0
• Sorting receptor SORCS2 facilitates a protective stress response in pancreatic islets
  Oleksandra Kalnytska, Per Qvist, Séverine Kunz, Thomas Conrad, Thomas E. Willnow and Vanessa Schmidt. iScience. DOI: 10.1016/j.isci.2023.108725
• Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina
  Thomas Stax Jakobsen, Jakob Appel Østergaard, Mads Kjolby, Elisa Lund Birch, Toke Bek, Anders Nykjær, Thomas J Corydon and Anne Louise Askou. Retina, 2023. DOI: 10.1167/iovs.64.7.8
• SorCS2 binds progranulin and regulates motor axon outgrowth
  Thomasen P, Salasova A, Login H, Beel S, Tranbjerg-Jensen J, Qvist P, Ovesen PL, Nolte S, Nejsum LN, Chao MV, Van Damme P, Kjaer-Sorensen, Oxvig C, Nykjær A. Cell Reports. DOI:  10.1016/j.celrep.2023.113333
• High-Dose Vitamin D Supplementation Significantly Affecs the Placental Transcriptome
  Vestergaard AL, Andersen MK, Olesen RV, Bor P, Larsen A. Nutrients. DOI:  10.1101/2023.02.08.527602
• Itaconate enhances oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
  Kurmasheva N, Said A, Wong B, Kress A, Liu Z, Wang C, Carter-Timofte M, Holm E, van der Horst D, Hoang H, Twayana K, Ottosen R, Svenningsen E, Begnini F, Kiib A, Weiss H, di Carlo D, Muscolini M, Higgins M, Kinderman P, van der Heijden, Tong T, Ozsvar A, Hou WH, Schack V, Holm C, van Montfoort N, Zheng Y, Ruzek M, Kalucka J, de la Vega L, Elgaher W, Korshoej A, Lin R, Hiscott J, Poulsen T, O'Neill L, Diallo JS, FArin H, Alain T, Olagnier D. Preprint at Researchsuare. DOI:  10.21203/rs.3.rs-3035315/v1

Upcoming and past events

• Workshop - Hands on basic bioinformatics
  Paludan lab thematic day. 
  August 2023
• AU HEALTH - Interdisciplinary Research Meeting
  Presentation of the Bioinformatics Core Facility. Find slides from the meeting here.
  May 2023
• PhD Course - Single cell and spatial OMICS (Basic Course)
  Core staff will contribute the upcoming course in single cell and spatial OMICS offered by AU HEALTH PhD school. Read more about the course here.
  May 2023
• Meet-and-Greet - Introduction to the Bioinformatics Core Facility 
  Paludan lab. Find slides from the seminar here.
  February 2023
• Workshop - Analysis of bulk RNA-sequencing data using Galaxy and UCloud
  A physical workshop with the subject of analyzing bulk RNA-sequencing data. The participants will be presented to the computational workflow of analyzing bulk RNA-sequencing data including file formats, file information, data processing, result generation, and interpretation. The workshop will include a live analysis and description for participants to do their work themself - without the need of coding experience. Find slides from the workshop here.
  19th January 2023
• Seminar - Introduction to the Bioinformatics Core Facility and its use in single cell analyses
  OMICs focus group meeting 3. Find slides from the seminar here.
  October 2022