The laboratory of kidney omics and metabolism, led by Markus Rinschen, investigates the molecular processes that lead to chronic kidney disease. One out of ten people suffer from chronic kidney disease, an unmet burden to individuals and societies. Common causes are hypertension, diabetes, or genetic or environmental factors. Our key hypothesis is that understanding of molecular tissue pathophysiology and metabolism provides new avenues to treat and intervene with progression of chronic kidney disease. To approach this, we use a wide array of metabolic, mass spectrometric and bioinformatics tools, and integrate and benchmark big data sets with physiological function. Our results have unraveled new approaches and omics-guided targets for kidney disease in mice and men, in particular in the area of glomerular kidney disease.