Genomics of externalizing psychiatric disorders

We perform large-scale genomics studies of externalizing childhood psychiatric disorders and substance use disorders, including thousands of individuals and millions of genetic

The studies include both analyses of common genetic variants (genome-wide association studies) and analyses of rare variants (next generation sequencing).

We combine the results from our genetic analyses with functional genomics data to identify risk genes, gene sets, tissue and cell types involved in the disorders we study.

We characterize the polygenic architecture of the disorders through genetic correlation and PRS analyses.

A large part of our research is based on the iPSYCH cohort, which is a large Danish population-based case cohort that has been established to study genetic and environmental causes for major psychiatric disorders.