Publications
Nielsen, H. M., Andersen, C. L., Westman, M., Kristensen, L. S., Asmar, F., Kruse, T. A., Thomassen, M., Larsen, T. S., Skov, V., Hansen, L. L., Bjerrum, O. W., Hasselbalch, H. C., Punj, V. & Grønbæk, K. (2018). Erratum to: Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations (Scientific Reports, (2017), 7, 1, (6774), 10.1038/s41598-017-07057-3). Scientific Reports, 8(1), Article 17311. https://doi.org/10.1038/s41598-018-35596-w
Dahl, M., Kristensen, L. S. & Grønbæk, K. (2018). Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy. International Journal of Molecular Sciences , 19(9), Article 2475. https://doi.org/10.3390/ijms19092475
Wedge, E., Hansen, J. W., Garde, C., Asmar, F., Tholstrup, D., Kristensen, S. S., Munch-Petersen, H. D., Ralfkiaer, E., Brown, P., Grønbæk, K. & Kristensen, L. S. (2017). Global hypomethylation is an independent prognostic factor in diffuse large B cell lymphoma. American Journal of Hematology, 92(7), 689-694. https://doi.org/10.1002/ajh.24751
Kristensen, L. S., Michaelsen, S. R., Dyrbye, H., Aslan, D., Grunnet, K., Christensen, I. J., Poulsen, H. S., Grønbæk, K. & Broholm, H. (2016). Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma. Journal of Neuropathology and Experimental Neurology, 75(3), 246-255. https://doi.org/10.1093/jnen/nlv024
Daugaard, I., Dominguez, D., Kjeldsen, T. E., Kristensen, L. S., Hager, H., Wojdacz, T. K. & Hansen, L. L. (2016). Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma. Scientific Reports, 6, Article 35807. https://doi.org/10.1038/srep35807
Hansen, J. W., Westman, M. K., Sjö, L. D., Saft, L., Kristensen, L. S., Ørskov, A. D., Treppendahl, M., Andersen, M. K. & Grønbaek, K. (2016). Mutations in idiopathic cytopenia of undetermined significance assist diagnostics and correlate to dysplastic changes. American Journal of Hematology, 91(12), 1234-1238. https://doi.org/10.1002/ajh.24554
Munch-Petersen, H. D., Asmar, F., Dimopoulos, K., Areškevičiūtė, A., Brown, P., Girkov, M. S., Pedersen, A., Sjö, L. D., Heegaard, S., Broholm, H., Kristensen, L. S., Ralfkiaer, E. & Grønbæk, K. (2016). TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy. Acta Neuropathologica Communications, 4, 40. https://doi.org/10.1186/s40478-016-0307-6
Aslan, D., Garde, C., Nygaard, M. K., Helbo, A. S., Dimopoulos, K., Hansen, J. W., Severinsen, M. T., Treppendahl, M. B., Sjø, L. D., Grønbæk, K. & Kristensen, L. S. (2016). Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations. OncoTarget, 7(9), 9951-9963. https://doi.org/10.18632/oncotarget.7127
Helbo, A. S., Treppendahl, M., Aslan, D., Dimopoulos, K., Nandrup-Bus, C., Holm, M. S., Andersen, M. K., Liang, G., Kristensen, L. S. & Grønbæk, K. (2015). Hypermethylation of the VTRNA1-3 Promoter is Associated with Poor Outcome in Lower Risk Myelodysplastic Syndrome Patients. Genes, 6(4), 977-90. https://doi.org/10.3390/genes6040977
Kristensen, L. S., Søes, S. & Hansen, L. L. (2014). ELMO3: a direct driver of cancer metastasis? Cell Cycle, 13(16), 2483-4. https://doi.org/10.4161/15384101.2014.947228
Borgbo, T., Sommer Kristensen, L., Lindgren, I., Yding Andersen, C. & Hansen, L. L. (2014). Genotyping common FSHR polymorphisms based on competitive amplification of differentially melting amplicons (CADMA). Journal of Assisted Reproduction and Genetics. https://doi.org/10.1007/s10815-014-0329-6
Søes, S., Daugaard, I. L., Sørensen, B. S., Carus, A., Mattheisen, M., Alsner, J., Overgaard, J., Hager, H., Hansen, L. L. & Kristensen, L. S. (2014). Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation. Oncoscience, 1(5), 367-74. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278312/
Lade-Keller, J., Kristensen, L. S., Riber-Hansen, R., Guldberg, P., Hansen, L. L., Steiniche, T. & Hager, H. (2013). A role for immunohistochemical detection of BRAF V600E prior to BRAF-inhibitor treatment of malignant melanoma? Journal of Clinical Pathology, 66(8), 723-5. https://doi.org/10.1136/jclinpath-2013-201483
Kristensen, L. S., Hansen, L. L., Lade-Keller, J., Riber-Hansen, R., Steiniche, T., Hager, H. & Guldberg, P. (2013). Author's reply. The Journal of molecular diagnostics : JMD, 15(4), 536-7.
Lade-Keller, J., Rømer, K. M., Guldberg, P., Riber-Hansen, R., Hansen, L. L., Steiniche, T., Hager, H. & Kristensen, L. S. (2013). Evaluation of BRAF mutation testing methodologies in formalin-fixed, paraffin-embedded cutaneous melanomas. The Journal of molecular diagnostics : JMD, 15(1), 70-80. https://doi.org/10.1016/j.jmoldx.2012.08.003
Søes, S., Sørensen, B. S., Alsner, J., Overgaard, J., Hager, H., Hansen, L. L. & Kristensen, L. S. (2013). Identification of accurate reference genes for RT-qPCR analysis of formalin-fixed paraffin-embedded tissue from primary Non-Small Cell Lung Cancers and brain and lymph node metastases. Lung Cancer, 81(2), 180-186. https://doi.org/10.1016/j.lungcan.2013.04.007
Kristensen, L. S., Treppendahl, M. B., Asmar, F., Girkov, M. S., Nielsen, H. M., Kjeldsen, T. E., Ralfkiaer, E., Hansen, L. L. & Grønbæk, K. (2013). Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing. Scientific Reports, 3, 2789. https://doi.org/10.1038/srep02789
Palma, J. F., Shieh, F., Kristensen, L. S., Hansen, L. L., Lade-Keller, J., Riber-Hansen, R., Steiniche, T., Hager, H. & Guldberg, P. (2013). The challenges of comparing a clinically validated test to other methods. Journal of Molecular Diagnostics, 15(4), 535-537.
Kristensen, L. S., Andersen, G. B., Hager, H. & Hansen, L. L. (2012). Competitive amplification of differentially melting amplicons (CADMA) enables sensitive and direct detection of all mutation types by high-resolution melting analysis. Human Mutation, 33(1), 264-71. https://doi.org/10.1002/humu.21598
Kristensen, L. S., Kjeldsen, T. E., Hager, H. & Hansen, L. L. (2012). Competitive amplification of differentially melting amplicons (CADMA) improves KRAS hotspot mutation testing in colorectal cancer. B M C Cancer, 12, 548. https://doi.org/10.1186/1471-2407-12-548
Kristensen, L. S. (2012). Sensitive Detection of DNA Methylation and Point Mutations in Cancer (epi) Genomes: Application to Personalized Medicine. Aarhus Universitet.
Wojdacz, T. K., Møller, T. H., Thestrup, B. B., Kristensen, L. S. & Hansen, L. L. (2010). Limitations and advantages of MS-HRM and bisulfite sequencing for single locus methylation studies. Expert Review of Molecular Diagnostics, 10(5), 575-580.
Kristensen, L. S., Nielsen, H. M., Hager, H. & Hansen, L. L. (2010). Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP. Lung Cancer.
Kristensen, L. S., Myrtue Nielsen, H. & Hansen, L. L. (2009). Epigenetics and cancer treatment. European Journal of Pharmacology, 625(1 - 3), 131 - 142.
Kristensen, L. S. & Hansen, L. L. (2009). PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment. Clinical Chemistry, 55(8), 1471-83. https://doi.org/10.1373/clinchem.2008.121962
Kristensen, L. S., Wojdacz, T. K., Thestrup, B. B., Wiuf, C. H., Hager, H. & Hansen, L. L. (2009). Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM. B M C Cancer, 9(453), 453.
Kristensen, L. S. & Dobrovic, A. (2008). Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis. Cancer Epidemiology, Biomarkers & Prevention, 17(5), 1240-7. https://doi.org/10.1158/1055-9965.EPI-07-2531
Dobrovic, A. & Kristensen, L. S. (2008). DNA methylation, epimutations and cancer predisposition. International Journal of Biochemistry & Cell Biology, 41(1), 34-9. https://doi.org/10.1016/j.biocel.2008.09.006
Kristensen, L. S., Mikeska, T., Krypuy, M. & Dobrovic, A. (2008). Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection. Nucleic Acids Research, 36(7), e42. https://doi.org/10.1093/nar/gkn113