Publications
Hansen, J. W., Westman, M. K., Sjö, L. D., Saft, L., Kristensen, L. S., Ørskov, A. D., Treppendahl, M., Andersen, M. K. & Grønbaek, K. (2016). Mutations in idiopathic cytopenia of undetermined significance assist diagnostics and correlate to dysplastic changes. American Journal of Hematology, 91(12), 1234-1238. https://doi.org/10.1002/ajh.24554
Munch-Petersen, H. D., Asmar, F., Dimopoulos, K., Areškevičiūtė, A., Brown, P., Girkov, M. S., Pedersen, A., Sjö, L. D., Heegaard, S., Broholm, H., Kristensen, L. S., Ralfkiaer, E. & Grønbæk, K. (2016). TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy. Acta Neuropathologica Communications, 4, 40. https://doi.org/10.1186/s40478-016-0307-6
Aslan, D., Garde, C., Nygaard, M. K., Helbo, A. S., Dimopoulos, K., Hansen, J. W., Severinsen, M. T., Treppendahl, M. B., Sjø, L. D., Grønbæk, K. & Kristensen, L. S. (2016). Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations. OncoTarget, 7(9), 9951-63. https://doi.org/10.18632/oncotarget.7127
Helbo, A. S., Treppendahl, M., Aslan, D., Dimopoulos, K., Nandrup-Bus, C., Holm, M. S., Andersen, M. K., Liang, G., Kristensen, L. S. & Grønbæk, K. (2015). Hypermethylation of the VTRNA1-3 Promoter is Associated with Poor Outcome in Lower Risk Myelodysplastic Syndrome Patients. Genes, 6(4), 977-90. https://doi.org/10.3390/genes6040977
Kristensen, L. S., Søes, S. & Hansen, L. L. (2014). ELMO3: a direct driver of cancer metastasis? Cell Cycle, 13(16), 2483-4. https://doi.org/10.4161/15384101.2014.947228
Borgbo, T., Sommer Kristensen, L., Lindgren, I., Yding Andersen, C. & Hansen, L. L. (2014). Genotyping common FSHR polymorphisms based on competitive amplification of differentially melting amplicons (CADMA). Journal of Assisted Reproduction and Genetics. https://doi.org/10.1007/s10815-014-0329-6
Søes, S., Daugaard, I. L., Sørensen, B. S., Carus, A., Mattheisen, M., Alsner, J., Overgaard, J., Hager, H., Hansen, L. L. & Kristensen, L. S. (2014). Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation. Oncoscience, 1(5), 367-74. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278312/
Lade-Keller, J., Kristensen, L. S., Riber-Hansen, R., Guldberg, P., Hansen, L. L., Steiniche, T. & Hager, H. (2013). A role for immunohistochemical detection of BRAF V600E prior to BRAF-inhibitor treatment of malignant melanoma? Journal of Clinical Pathology, 66(8), 723-5. https://doi.org/10.1136/jclinpath-2013-201483
Kristensen, L. S., Hansen, L. L., Lade-Keller, J., Riber-Hansen, R., Steiniche, T., Hager, H. & Guldberg, P. (2013). Author's reply. The Journal of molecular diagnostics : JMD, 15(4), 536-7.
Lade-Keller, J., Rømer, K. M., Guldberg, P., Riber-Hansen, R., Hansen, L. L., Steiniche, T., Hager, H. & Kristensen, L. S. (2013). Evaluation of BRAF mutation testing methodologies in formalin-fixed, paraffin-embedded cutaneous melanomas. The Journal of molecular diagnostics : JMD, 15(1), 70-80. https://doi.org/10.1016/j.jmoldx.2012.08.003
Søes, S., Sørensen, B. S., Alsner, J., Overgaard, J., Hager, H., Hansen, L. L. & Kristensen, L. S. (2013). Identification of accurate reference genes for RT-qPCR analysis of formalin-fixed paraffin-embedded tissue from primary Non-Small Cell Lung Cancers and brain and lymph node metastases. Lung Cancer, 81(2), 180-186. https://doi.org/10.1016/j.lungcan.2013.04.007
Kristensen, L. S., Treppendahl, M. B., Asmar, F., Girkov, M. S., Nielsen, H. M., Kjeldsen, T. E., Ralfkiaer, E., Hansen, L. L. & Grønbæk, K. (2013). Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing. Scientific Reports, 3, 2789. https://doi.org/10.1038/srep02789
Palma, J. F., Shieh, F., Kristensen, L. S., Hansen, L. L., Lade-Keller, J., Riber-Hansen, R., Steiniche, T., Hager, H. & Guldberg, P. (2013). The challenges of comparing a clinically validated test to other methods. Journal of Molecular Diagnostics, 15(4), 535-537.
Kristensen, L. S., Andersen, G. B., Hager, H. & Hansen, L. L. (2012). Competitive amplification of differentially melting amplicons (CADMA) enables sensitive and direct detection of all mutation types by high-resolution melting analysis. Human Mutation, 33(1), 264-71. https://doi.org/10.1002/humu.21598
Kristensen, L. S., Kjeldsen, T. E., Hager, H. & Hansen, L. L. (2012). Competitive amplification of differentially melting amplicons (CADMA) improves KRAS hotspot mutation testing in colorectal cancer. B M C Cancer, 12, 548. https://doi.org/10.1186/1471-2407-12-548
Kristensen, L. S. (2012). Sensitive Detection of DNA Methylation and Point Mutations in Cancer (epi) Genomes: Application to Personalized Medicine. Århus Universitet.
Wojdacz, T. K., Møller, T. H., Thestrup, B. B., Kristensen, L. S. & Hansen, L. L. (2010). Limitations and advantages of MS-HRM and bisulfite sequencing for single locus methylation studies. Expert Review of Molecular Diagnostics, 10(5), 575-580.
Kristensen, L. S., Nielsen, H. M., Hager, H. & Hansen, L. L. (2010). Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP. Lung Cancer.
Kristensen, L. S., Myrtue Nielsen, H. & Hansen, L. L. (2009). Epigenetics and cancer treatment. European Journal of Pharmacology, 625(1 - 3), 131 - 142.
Kristensen, L. S. & Hansen, L. L. (2009). PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment. Clinical Chemistry, 55(8), 1471-83. https://doi.org/10.1373/clinchem.2008.121962
Kristensen, L. S., Wojdacz, T. K., Thestrup, B. B., Wiuf, C. H., Hager, H. & Hansen, L. L. (2009). Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM. B M C Cancer, 9(453), 453.
Kristensen, L. S. & Dobrovic, A. (2008). Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis. Cancer Epidemiology, Biomarkers & Prevention, 17(5), 1240-7. https://doi.org/10.1158/1055-9965.EPI-07-2531
Dobrovic, A. & Kristensen, L. S. (2008). DNA methylation, epimutations and cancer predisposition. International Journal of Biochemistry & Cell Biology, 41(1), 34-9. https://doi.org/10.1016/j.biocel.2008.09.006
Kristensen, L. S., Mikeska, T., Krypuy, M. & Dobrovic, A. (2008). Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection. Nucleic Acids Research, 36(7), e42. https://doi.org/10.1093/nar/gkn113