Publications
Okholm, T. L. H., Kamstrup, A. B., Nielsen, M. M., Hollensen, A. K., Graversgaard, M. L., Sørensen, M. H., Kristensen, L. S., Vang, S., Park, S. S., Yeo, E., Dyrskjøt, L., Kjems, J., Pedersen, J. S. & Damgaard, C. K. (2024). circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. eLife, 13, Article RP91783. https://doi.org/10.7554/eLife.91783
Ørbeck, S. V., Jakobsen, T., García-Rodríguez, J. L., Burton, M., Rasmussen, L. G., Ewald, J. D., Fristrup, C. W., Pfeiffer, P., Mortensen, M. B., Kristensen, L. S. & Detlefsen, S. (2024). Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling. Pancreatology, 24(5), 706-718. https://doi.org/10.1016/j.pan.2024.04.004
Orr, M. E., Kulasinghe, A., Kolar, G. R., Heyn, H., Plummer, J., Sommer Kristensen, L., Kjems, J., Mills, G., Garcia-Vallejo, J. J., Nijman, I. J., West, N. P. & Cox, A. (2024). Sounding an Alarm over Spatial Biology. Genetic Engineering and Biotechnology News, 44(3), 16-17. https://doi.org/10.1089/gen.44.03.07
Jakobsen, T., Pløen, G. G., Behsen, A. D., Møller, H. J., Plesner, T., Dybkær, K., Andersen, M. N., Misund, K. & Kristensen, L. S. (2024). The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells. Journal of Cellular and Molecular Medicine, 28(22), Article e70215. https://doi.org/10.1111/jcmm.70215
Korsgaard, U., García-Rodríguez, J. L., Jakobsen, T., Ahmadov, U., Dietrich, K. G., Vissing, S. M., Paasch, T. P., Lindebjerg, J., Kjems, J., Hager, H. & Kristensen, L. S. (2024). The Transcriptional Landscape of Coding and Noncoding RNAs in Recurrent and Nonrecurrent Colon Cancer. American Journal of Pathology, 194(8), 1424-1442. https://doi.org/10.1016/j.ajpath.2024.04.003
Seeler, S., Andersen, M. S., Sztanka-Toth, T., Rybiczka-Tešulov, M., van den Munkhof, M. H., Chang, C. C., Maimaitili, M., Venø, M. T., Hansen, T. B., Pasterkamp, R. J., Rybak-Wolf, A., Denham, M., Rajewsky, N., Kristensen, L. S. & Kjems, J. (2023). A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development. Molecular Neurobiology, 60(6), 3239–3260. https://doi.org/10.1007/s12035-023-03253-7
Okholm, T. L. H., Kamstrup, A. B., Nielsen, M. M., Hollensen, A. K., Graversgaard, M. L., Kristensen, L. S., Vang, S., Park, S. S., Yeo, G. W., Dyrskjøt, L., Kjems, J., Pedersen, J. S. & Damgaard, C. K. (2023). circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. https://doi.org/10.1101/2023.09.14.557527
Tolomeo, D., Traversa, D., Venuto, S., Ebbesen, K., Garcia Rodriguez, J. L., Tamma, G., Ranieri, M., Simonetti, G., Ghetti, M., Paganelli, M., Visci, G., Liso, A., Kok, K., Muscarella, L. A., Fabrizio, F. P., Frassanito, M. A., Lamanuzzi, A., Saltarella, I., Solimando, A. G. ... Storlazzi, C. T. (2023). circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer. Genes, Chromosomes & Cancer, 62(7), 377-391. https://doi.org/10.1002/gcc.23121
Granau, A. M., Andersen, P. A., Jakobsen, T., Taouxi, K., Dalila, N., Mogensen, J. B., Kristensen, L. S., Grønbæk, K. & Dimopoulos, K. (2023). Concurrent Inhibition of Akt and ERK Using TIC-10 Can Overcome Venetoclax Resistance in Mantle Cell Lymphoma. Cancers, 15(2), Article 510. https://doi.org/10.3390/cancers15020510
Ben Abdallah, H., Seeler, S., Bregnhøj, A., Ghatnekar, G., Kristensen, L. S., Iversen, L. & Johansen, C. (2023). Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation. Frontiers in Immunology, 14, Article 1128897. https://doi.org/10.3389/fimmu.2023.1128897
Wedge, E., Ahmadov, U., Hansen, T. B., Gao, Z., Tulstrup, M., Côme, C., Nonavinkere Srivatsan, S., Ahmed, T., Jespersen, J. S., Schlotmann, B. C., Schöllkopf, C., Raaschou-Jensen, K., Ødum, N., Kjems, J., Bak, R. O., Walter, M. J., Grønbæk, K. & Kristensen, L. S. (2023). Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. Leukemia, 37(5), 1113-1125. https://doi.org/10.1038/s41375-023-01866-4
García-Rodríguez, J. L., Korsgaard, U., Ahmadov, U., Jarlstad Olesen, M. T., Dietrich, K.-G., Hansen, E. B., Vissing, S. M., Ulhøi, B. P., Dyrskjøt, L., Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2023). Spatial profiling of circular RNAs in cancer reveals high expression in muscle and stromal cells. Cancer Research, 83(20), 3340–3353. https://doi.org/10.1158/0008-5472.CAN-23-0748
Nielsen, A. F., Bindereif, A., Bozzoni, I., Hanan, M., Hansen, T. B., Irimia, M., Kadener, S., Kristensen, L. S., Legnini, I., Morlando, M., Olesen, M. T. J., Pasterkamp, R. J., Preibisch, S., Rajewsky, N., Sünkel, C. & Kjems, J. (2022). Best practice standards for circular RNA research. Nature Methods, 19(10), 1208-1220. https://doi.org/10.1038/s41592-022-01487-2
Dahl, M., Husby, S., Eskelund, C. W., Besenbacher, S., Fjelstrup, S., Côme, C., Ek, S., Kolstad, A., Räty, R., Jerkeman, M., Geisler, C. H., Kjems, J., Kristensen, L. S. & Grønbæk, K. (2022). Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials. Leukemia, 36(1), 177-188. https://doi.org/10.1038/s41375-021-01311-4
Seeler, S., Moldovan, L.-I., Bertelsen, T., Hager, H., Iversen, L., Johansen, C., Kjems, J. & Sommer Kristensen, L. (2022). Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment. PLOS ONE, 17(9), Article e0275219. https://doi.org/10.1371/journal.pone.0275219
Kristensen, M. B., Ahmadov, U., Nielsen, M. A., Kristensen, L. S. & Kragstrup, T. W. (2022). In vitro response to disease modifying antirheumatic drugs link molecular drug target with synovial transcriptional signature. Annals of the Rheumatic Diseases, 81(Suppl 1), Article POS0293. https://doi.org/10.1136/annrheumdis-2022-eular.2512
Khanbabaei, H., Ebrahimi, S., García-Rodríguez, J. L., Ghasemi, Z., Pourghadamyari, H., Mohammadi, M. & Kristensen, L. S. (2022). Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications. Journal of Experimental and Clinical Cancer Research, 41(1), Article 278. https://doi.org/10.1186/s13046-022-02488-x
Kristensen, L. S., Jakobsen, T., Hager, H. & Kjems, J. (2022). The emerging roles of circRNAs in cancer and oncology. Nature Reviews. Clinical Oncology, 19(3), 188-206. https://doi.org/10.1038/s41571-021-00585-y
Hansen, E. K. B., Fredsøe, J. H., Okholm, T. L. H., Ulhøi, B. P., Klingenberg, S., Jensen, J. B., Kjems, J., Bouchelouche, K., Borre, M., Damgaard, C. K., Pedersen, J. S., Kristensen, L. S. & Sørensen, K. D. (2022). The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer. Genome Medicine, 14(1), Article 8. https://doi.org/10.1186/s13073-021-01009-3
van der Sluis, R. M., Cham, L. B., Gris-Oliver, A., Gammelgaard, K. R., Pedersen, J. G., Idorn, M., Ahmadov, U., Hernandez, S. S., Cémalovic, E., Godsk, S. H., Thyrsted, J., Gunst, J. D., Nielsen, S. D., Jørgensen, J. J., Bjerg, T. W., Laustsen, A., Reinert, L. S., Olagnier, D., Bak, R. O. ... Jakobsen, M. R. (2022). TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection. EMBO Journal, 41(10), Article e109622. https://doi.org/10.15252/embj.2021109622
Traversa, D., Simonetti, G., Tolomeo, D., Visci, G., Macchia, G., Ghetti, M., Martinelli, G., Kristensen, L. S. & Storlazzi, C. T. (2022). Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. British Journal of Cancer, 126(6), 835-850. https://doi.org/10.1038/s41416-021-01584-7
Alsing, S., Doktor, T. K., Askou, A. L., Jensen, E. G., Ahmadov, U., Kristensen, L. S., Andresen, B. S., Aagaard, L. & Corydon, T. J. (2022). VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy. Molecular Therapy - Nucleic Acids, 28, 58-76. https://doi.org/10.1016/j.omtn.2022.02.019
Moldovan, L. I., Tsoi, L. C., Ranjitha, U., Hager, H., Weidinger, S., Gudjonsson, J. E., Kjems, J. & Kristensen, L. S. (2021). Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles. Experimental Dermatology, 30(8), 1187-1196. https://doi.org/10.1111/exd.14227
Olesen, M. T. J. & Kristensen, L. S. (2021). Circular RNAs as microRNA sponges: Evidence and controversies. Essays in Biochemistry, 65(4), 685-696. https://doi.org/10.1042/EBC20200060
Ahmadov, U., Bendikas, M. M., Ebbesen, K. K., Sehested, A. M., Kjems, J., Broholm, H. & Kristensen, L. S. (2021). Distinct circular RNA expression profiles in pediatric ependymomas. Brain Pathology, 31(2), 387-392. https://doi.org/10.1111/bpa.12922
Jakobsen, T., Dahl, M., Dimopoulos, K., Grønbæk, K., Kjems, J. & Kristensen, L. S. (2021). Genome-wide circular RNA expression patterns reflect resistance to immunomodulatory drugs in multiple myeloma cells. Cancers, 13(3), Article 365. https://doi.org/10.3390/cancers13030365
Kristensen, L. S. (2021). Profiling of circRNAs using an enzyme-free digital counting method. Methods, 196, 11-16. https://doi.org/10.1016/j.ymeth.2021.02.004
Hansen, R. S., Thuesen, K. K., Bregnhøj, A., Moldovan, L. I., Kristensen, L. S., Grek, C. L., Ghatnekar, G. S., Iversen, L. & Johansen, C. (2021). The HSP90 inhibitor RGRN-305 exhibits strong immunomodulatory effects in human keratinocytes. Experimental Dermatology, 30(6), 773-781. https://doi.org/10.1111/exd.14302
Das Mahapatra, K., Pasquali, L., Søndergaard, J. N., Lapins, J., Nemeth, I. B., Baltás, E., Kemény, L., Homey, B., Moldovan, L. I., Kjems, J., Kutter, C., Sonkoly, E., Kristensen, L. S. & Pivarcsi, A. (2020). A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma. Scientific Reports, 10, Article 3637. https://doi.org/10.1038/s41598-020-59660-6
Hait, A. S., Olagnier, D., Sancho-Shimizu, V., Skipper, K. A., Helleberg, M., Larsen, S. M., Bodda, C., Moldovan, L. I., Ren, F., Brinck Andersen, N.-S., Thomsen, M. M., Freytag, M. R., Darmalinggam, S., Parkes, I., Kadekar, D. D., Rahbek, S. H., van der Horst, D., Kristensen, L. S., Eriksson, K. ... Mogensen, T. H. (2020). Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. Science Immunology, 5(54), Article eabc2691. https://doi.org/10.1126/sciimmunol.abc2691
Kristensen, L. S., Ebbesen, K. K., Sokol, M., Jakobsen, T., Korsgaard, U., Eriksen, A. C., Hansen, T. B., Kjems, J. & Hager, H. (2020). Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. Nature Communications, 11, Article 4551. https://doi.org/10.1038/s41467-020-18355-2
Moldovan, L.-I., Hansen, T. B., Venø, M. T., Okholm, T. L. H., Andersen, T. L., Hager, H., Iversen, L., Kjems, J., Johansen, C. & Kristensen, L. S. (2019). High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome. BMC Medical Genomics, 12(1), Article 174. https://doi.org/10.1186/s12920-019-0616-2
Thomsen, M. M., Jørgensen, S. E., Storgaard, M., Kristensen, L. S., Gjedsted, J., Christiansen, M., Gad, H. H., Hartmann, R. & Mogensen, T. H. (2019). Identification of an IRF3 variant and defective antiviral interferon responses in a patient with severe influenza. European Journal of Immunology, 49(11), 2111-2114. https://doi.org/10.1002/eji.201848083
Kristensen, L. S., Schertz Andersen, M., Stagsted, L. V. W., Ebbesen, K., Hansen, T. B. & Kjems, J. (2019). The biogenesis, biology and characterization of circular RNAs. Nature Reviews. Genetics, 20(11), 675-691. https://doi.org/10.1038/s41576-019-0158-7
Kristensen, L. S., Okholm, T. L. H., Venø, M. T. & Kjems, J. (2018). Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation. RNA Biology, 15(2), 1-12. https://doi.org/10.1080/15476286.2017.1409931
Kristensen, L. S., Hansen, T. B., Venø, M. T. & Kjems, J. (2018). Circular RNAs in cancer: opportunities and challenges in the field. Oncogene, 37(5), 555–565. https://doi.org/10.1038/onc.2017.361
Michaelsen, S. R., Aslan, D., Urup, T., Poulsen, H. S., Grønbæk, K., Broholm, H. & Kristensen, L. S. (2018). DNA methylation levels of the ELMO gene promoter CpG islands in human glioblastomas. International Journal of Molecular Sciences , 19(3), Article 679. https://doi.org/10.3390/ijms19030679
Dimopoulos, K., Søgaard Helbo, A., Fibiger Munch-Petersen, H., Sjö, L., Christensen, J., Sommer Kristensen, L., Asmar, F., Hermansen, N. E. U., O'Connel, C., Gimsing, P., Liang, G. & Grønbaek, K. (2018). Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner. Molecular Oncology, 12(2), 180-195. https://doi.org/10.1002/1878-0261.12157
Dahl, M., Daugaard, I., Andersen, M. S., Hansen, T. B., Grønbæk, K., Kjems, J. & Kristensen, L. S. (2018). Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies. Laboratory Investigation, 98(12), 1657–1669. https://doi.org/10.1038/s41374-018-0108-6
Nielsen, H. M., Andersen, C. L., Westman, M., Kristensen, L. S., Asmar, F., Kruse, T. A., Thomassen, M., Larsen, T. S., Skov, V., Hansen, L. L., Bjerrum, O. W., Hasselbalch, H. C., Punj, V. & Grønbæk, K. (2018). Erratum to: Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations (Scientific Reports, (2017), 7, 1, (6774), 10.1038/s41598-017-07057-3). Scientific Reports, 8(1), Article 17311. https://doi.org/10.1038/s41598-018-35596-w
Dahl, M., Kristensen, L. S. & Grønbæk, K. (2018). Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy. International Journal of Molecular Sciences , 19(9), Article 2475. https://doi.org/10.3390/ijms19092475
Wedge, E., Hansen, J. W., Garde, C., Asmar, F., Tholstrup, D., Kristensen, S. S., Munch-Petersen, H. D., Ralfkiaer, E., Brown, P., Grønbæk, K. & Kristensen, L. S. (2017). Global hypomethylation is an independent prognostic factor in diffuse large B cell lymphoma. American Journal of Hematology, 92(7), 689-694. https://doi.org/10.1002/ajh.24751
Kristensen, L. S., Michaelsen, S. R., Dyrbye, H., Aslan, D., Grunnet, K., Christensen, I. J., Poulsen, H. S., Grønbæk, K. & Broholm, H. (2016). Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma. Journal of Neuropathology and Experimental Neurology, 75(3), 246-55. https://doi.org/10.1093/jnen/nlv024
Daugaard, I., Dominguez, D., Kjeldsen, T. E., Kristensen, L. S., Hager, H., Wojdacz, T. K. & Hansen, L. L. (2016). Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma. Scientific Reports, 6, Article 35807. https://doi.org/10.1038/srep35807
Hansen, J. W., Westman, M. K., Sjö, L. D., Saft, L., Kristensen, L. S., Ørskov, A. D., Treppendahl, M., Andersen, M. K. & Grønbaek, K. (2016). Mutations in idiopathic cytopenia of undetermined significance assist diagnostics and correlate to dysplastic changes. American Journal of Hematology, 91(12), 1234-1238. https://doi.org/10.1002/ajh.24554
Munch-Petersen, H. D., Asmar, F., Dimopoulos, K., Areškevičiūtė, A., Brown, P., Girkov, M. S., Pedersen, A., Sjö, L. D., Heegaard, S., Broholm, H., Kristensen, L. S., Ralfkiaer, E. & Grønbæk, K. (2016). TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy. Acta Neuropathologica Communications, 4, 40. https://doi.org/10.1186/s40478-016-0307-6
Aslan, D., Garde, C., Nygaard, M. K., Helbo, A. S., Dimopoulos, K., Hansen, J. W., Severinsen, M. T., Treppendahl, M. B., Sjø, L. D., Grønbæk, K. & Kristensen, L. S. (2016). Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations. OncoTarget, 7(9), 9951-63. https://doi.org/10.18632/oncotarget.7127
Helbo, A. S., Treppendahl, M., Aslan, D., Dimopoulos, K., Nandrup-Bus, C., Holm, M. S., Andersen, M. K., Liang, G., Kristensen, L. S. & Grønbæk, K. (2015). Hypermethylation of the VTRNA1-3 Promoter is Associated with Poor Outcome in Lower Risk Myelodysplastic Syndrome Patients. Genes, 6(4), 977-90. https://doi.org/10.3390/genes6040977
Kristensen, L. S., Søes, S. & Hansen, L. L. (2014). ELMO3: a direct driver of cancer metastasis? Cell Cycle, 13(16), 2483-4. https://doi.org/10.4161/15384101.2014.947228
Borgbo, T., Sommer Kristensen, L., Lindgren, I., Yding Andersen, C. & Hansen, L. L. (2014). Genotyping common FSHR polymorphisms based on competitive amplification of differentially melting amplicons (CADMA). Journal of Assisted Reproduction and Genetics. https://doi.org/10.1007/s10815-014-0329-6