Publications
Kristensen, L. S., Søes, S. & Hansen, L. L. (2014). ELMO3: a direct driver of cancer metastasis? Cell Cycle, 13(16), 2483-4. https://doi.org/10.4161/15384101.2014.947228
Dimopoulos, K., Søgaard Helbo, A., Fibiger Munch-Petersen, H., Sjö, L., Christensen, J., Sommer Kristensen, L., Asmar, F., Hermansen, N. E. U., O'Connel, C., Gimsing, P., Liang, G. & Grønbaek, K. (2018). Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner. Molecular Oncology, 12(2), 180-195. https://doi.org/10.1002/1878-0261.12157
Michaelsen, S. R., Aslan, D., Urup, T., Poulsen, H. S., Grønbæk, K., Broholm, H. & Kristensen, L. S. (2018). DNA methylation levels of the ELMO gene promoter CpG islands in human glioblastomas. International Journal of Molecular Sciences , 19(3), Article 679. https://doi.org/10.3390/ijms19030679
Dobrovic, A. & Kristensen, L. S. (2008). DNA methylation, epimutations and cancer predisposition. International Journal of Biochemistry & Cell Biology, 41(1), 34-9. https://doi.org/10.1016/j.biocel.2008.09.006
van der Sluis, R. M., García-Rodríguez, J. L., Nielsen, I. H., Gris-Oliver, A., Becker, J., Costa, B., Chaudhry, M. Z., Werner, M., Laustsen, A., Pedersen, J. G., Gammelgaard, K. R., Mogensen, T. H., Kalinke, U., Cicin-Sain, L., Bak, R. O., Kristensen, L. S. & Jakobsen, M. R. (2025). Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells. Cell Reports, 44(3), Article 115413. https://doi.org/10.1016/j.celrep.2025.115413
Ahmadov, U., Bendikas, M. M., Ebbesen, K. K., Sehested, A. M., Kjems, J., Broholm, H. & Kristensen, L. S. (2021). Distinct circular RNA expression profiles in pediatric ependymomas. Brain Pathology, 31(2), 387-392. https://doi.org/10.1111/bpa.12922
Kristensen, L. S. & Dobrovic, A. (2008). Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis. Cancer Epidemiology, Biomarkers & Prevention, 17(5), 1240-7. https://doi.org/10.1158/1055-9965.EPI-07-2531
Hait, A. S., Olagnier, D., Sancho-Shimizu, V., Skipper, K. A., Helleberg, M., Larsen, S. M., Bodda, C., Moldovan, L. I., Ren, F., Brinck Andersen, N.-S., Thomsen, M. M., Freytag, M. R., Darmalinggam, S., Parkes, I., Kadekar, D. D., Rahbek, S. H., van der Horst, D., Kristensen, L. S., Eriksson, K. ... Mogensen, T. H. (2021). Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. Science Immunology, 5(54), Article eabc2691. https://doi.org/10.1126/sciimmunol.abc2691
Granau, A. M., Andersen, P. A., Jakobsen, T., Taouxi, K., Dalila, N., Mogensen, J. B., Kristensen, L. S., Grønbæk, K. & Dimopoulos, K. (2023). Concurrent Inhibition of Akt and ERK Using TIC-10 Can Overcome Venetoclax Resistance in Mantle Cell Lymphoma. Cancers, 15(2), Article 510. https://doi.org/10.3390/cancers15020510
Kristensen, L. S., Kjeldsen, T. E., Hager, H. & Hansen, L. L. (2012). Competitive amplification of differentially melting amplicons (CADMA) improves KRAS hotspot mutation testing in colorectal cancer. B M C Cancer, 12, 548. https://doi.org/10.1186/1471-2407-12-548
Kristensen, L. S., Andersen, G. B., Hager, H. & Hansen, L. L. (2012). Competitive amplification of differentially melting amplicons (CADMA) enables sensitive and direct detection of all mutation types by high-resolution melting analysis. Human Mutation, 33(1), 264-71. https://doi.org/10.1002/humu.21598
Paasch, T. P., Olesen, M. T. J., García-Rodríguez, J. L., Assmus, A. M., Fenton, R. A., Kjems, J., Hager, H. & Kristensen, L. S. (2025). ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. PLoS Genetics, 21(6), Article e1011726. https://doi.org/10.1371/journal.pgen.1011726
Kristensen, L. S., Hansen, T. B., Venø, M. T. & Kjems, J. (2018). Circular RNAs in cancer: opportunities and challenges in the field. Oncogene, 37(5), 555–565. https://doi.org/10.1038/onc.2017.361
Olesen, M. T. J. & Kristensen, L. S. (2021). Circular RNAs as microRNA sponges: Evidence and controversies. Essays in Biochemistry, 65(4), 685-696. https://doi.org/10.1042/EBC20200060
Kristensen, L. S., Okholm, T. L. H., Venø, M. T. & Kjems, J. (2018). Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation. RNA Biology, 15(2), 280-291. https://doi.org/10.1080/15476286.2017.1409931
Wedge, E., Tulstrup, M., Todisco, G., Moura, P., Côme, C., Hansen, J. W., Jespersen, J. S., Schlotmann, B., Creignou, M., Dahl, M., Schöllkopf, C., Raaschou-Jensen, K., Wennerberg, K., Porse, B., Weischenfeldt, J., Hellström-Lindberg, E., Kristensen, L. S. & Grønbæk, K. (2026). Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression. Molecular Oncology. Advance online publication. https://doi.org/10.1002/1878-0261.70208
Tolomeo, D., Traversa, D., Venuto, S., Ebbesen, K., Garcia Rodriguez, J. L., Tamma, G., Ranieri, M., Simonetti, G., Ghetti, M., Paganelli, M., Visci, G., Liso, A., Kok, K., Muscarella, L. A., Fabrizio, F. P., Frassanito, M. A., Lamanuzzi, A., Saltarella, I., Solimando, A. G. ... Storlazzi, C. T. (2023). circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer. Genes, Chromosomes & Cancer, 62(7), 377-391. https://doi.org/10.1002/gcc.23121
Okholm, T. L. H., Kamstrup, A. B., Nielsen, M. M., Hollensen, A. K., Graversgaard, M. L., Kristensen, L. S., Vang, S., Park, S. S., Yeo, G. W., Dyrskjøt, L., Kjems, J., Pedersen, J. S. & Damgaard, C. K. (2023). circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. https://doi.org/10.1101/2023.09.14.557527
Okholm, T. L. H., Kamstrup, A. B., Nielsen, M. M., Hollensen, A. K., Graversgaard, M. L., Sørensen, M. H., Kristensen, L. S., Vang, S., Park, S. S., Yeo, E., Dyrskjøt, L., Kjems, J., Pedersen, J. S. & Damgaard, C. K. (2024). circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. eLife, 13, Article RP91783. https://doi.org/10.7554/eLife.91783
Moldovan, L. I., Tsoi, L. C., Ranjitha, U., Hager, H., Weidinger, S., Gudjonsson, J. E., Kjems, J. & Kristensen, L. S. (2021). Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles. Experimental Dermatology, 30(8), 1187-1196. https://doi.org/10.1111/exd.14227
García-Rodríguez, J. L., Korsgaard, U., Vissing, S. M., Paasch, T. P., Semenova, M., Vendelbo, S. L., Jensby, E. F., Williams, H. L., Salachan, P. V., Brandt, C. B., Hanimann, J., Lin, L., Zlobec, I., Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2025). Cancer-associated fibroblasts shape the formation of budding cancer cells at the invasive front of human colorectal cancer. Communications Biology, 8(1), Article 1345. https://doi.org/10.1038/s42003-025-08799-x
Nielsen, A. F., Bindereif, A., Bozzoni, I., Hanan, M., Hansen, T. B., Irimia, M., Kadener, S., Kristensen, L. S., Legnini, I., Morlando, M., Olesen, M. T. J., Pasterkamp, R. J., Preibisch, S., Rajewsky, N., Sünkel, C. & Kjems, J. (2022). Best practice standards for circular RNA research. Nature Methods, 19(10), 1208-1220. https://doi.org/10.1038/s41592-022-01487-2
Kristensen, L. S., Hansen, L. L., Lade-Keller, J., Riber-Hansen, R., Steiniche, T., Hager, H. & Guldberg, P. (2013). Author's reply. The Journal of molecular diagnostics : JMD, 15(4), 536-7.
Kristensen, L. S., Michaelsen, S. R., Dyrbye, H., Aslan, D., Grunnet, K., Christensen, I. J., Poulsen, H. S., Grønbæk, K. & Broholm, H. (2016). Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma. Journal of Neuropathology and Experimental Neurology, 75(3), 246-255. https://doi.org/10.1093/jnen/nlv024
Lade-Keller, J., Kristensen, L. S., Riber-Hansen, R., Guldberg, P., Hansen, L. L., Steiniche, T. & Hager, H. (2013). A role for immunohistochemical detection of BRAF V600E prior to BRAF-inhibitor treatment of malignant melanoma? Journal of Clinical Pathology, 66(8), 723-5. https://doi.org/10.1136/jclinpath-2013-201483
Søkilde, R., Kaadt, E., Kristensen, L. S., Venø, M. T., Kjems, J., Nyengaard, J. R., Nielsen, B. S. & Elfving, B. (2025). Application of microRNA In Situ Hybridization on Long-term Stored Human Formalin-fixed Paraffin-embedded Brain Samples from Psychiatric Patients. Molecular Neurobiology, 62(10), 12736-12746. https://doi.org/10.1007/s12035-025-05077-z
Ahmadov, U., Udengaard, C. W., Vissing, S. M., Nielsen, S. D., Dietrich, K. G., Ulhøi, B. P. & Kristensen, L. S. (2026). A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis. Brain Pathology, Article e70071. Advance online publication. https://doi.org/10.1111/bpa.70071
Das Mahapatra, K., Pasquali, L., Søndergaard, J. N., Lapins, J., Nemeth, I. B., Baltás, E., Kemény, L., Homey, B., Moldovan, L. I., Kjems, J., Kutter, C., Sonkoly, E., Kristensen, L. S. & Pivarcsi, A. (2020). A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma. Scientific Reports, 10, Article 3637. https://doi.org/10.1038/s41598-020-59660-6
Seeler, S., Andersen, M. S., Sztanka-Toth, T., Rybiczka-Tešulov, M., van den Munkhof, M. H., Chang, C. C., Maimaitili, M., Venø, M. T., Hansen, T. B., Pasterkamp, R. J., Rybak-Wolf, A., Denham, M., Rajewsky, N., Kristensen, L. S. & Kjems, J. (2023). A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development. Molecular Neurobiology, 60(6), 3239–3260. https://doi.org/10.1007/s12035-023-03253-7