Daniela Gabriele Grimm

Group Leader

Daniela Gabriele Grimm
Professor MSO Space Medicine More information

RESEARCH
The lab at AU was started in August 2008 and our key interest covers two research areas: (i) Translational Medicine (Tissue Engineering of artificial vessels and cartilage) and (II) Space Medicine - the impact of microgravity on human cells.  

We test the growth behavior of 3D aggregates deriving from different cell types, for example thyroid carcinoma cells, chondrocytes and endothelial cells in weightlessness. 3D growth can be achieved by culturing cells on a Random Positioning Machine (RPM, Dutch Space, NL) or a Rotating Wall Vessel (Synthecon, USA). The investigation of spheroids might help to avoid animal tests in the field of pharmacology and medicine. They also can be used in cancer research. 

Furthermore, we investigate the Proteome of thyroid cancer cells and endothelial cells cultured under simulated microgravity and normal 1g conditions. Proteome analysis is performed in order to identify protein candidates changing under microgravity conditions.

The group participates in the training of bachelor, MSc and PhD students.

Research Funding: European Space Agency and German ‘Bundesministerium für Wirtschaft (BMWi)’

RESEARCH INTERESTS
Space Medicine, Space Pharmacology, Space Biology (DLR Parabolic flights, Spaceflights –ISS,  Chinese and Russian rockets).

Cardiovascular Pharmacology and Tumour Biology (mechanisms of apoptosis, ECM signalling,  new targets for cancer therapy, radiation)

Proteomics and Genomics in Microgravity

Tissue Engineering

Publications   (added by web-editor -PURE link)

METHODOLOGIES
Cellular biology (Cell cultures of human and mammalian cells, 3 D techniques (spinnerflask cultures))

Molecular biological methods (quantitative rt PCR)

Protein analysis: Western blotting, immunostaining, flow cytometry, microscopic techniques with image analyses, ELISAs

Histology, Immunocytochemistry

In cooperation with Dr. Gerhard Weber, Dr. Johann Bauer,  Munich- Free Flow Electrophoresis and  Professor Albert Sickmann ISAS Institute,  Dortmund (Mass Spectrometry) – Proteomics

Simulation of weightlessness

 COLLABORATORS & CENTERS

  • Ulf Simonsen, Thomas Dalsgaard, Department of Biomedicine, Pharmacology, Aarhus University, Denmark
  • Fen Zhuang, Bejing University of Aeronautics and Astronautics, Beihang University, Beijing, China
  • Chun Yang, Institute of Biomechanics and Medical Engineering, School of Aerospace, Tsinghua University, Beijing
  • Petra Wise, Department of Pediatrics, Immunology, Allergy, and Rheumatology, UCLA, Los Angeles, California, USA
  • Ruth Hemmersbach, Jens Hauslage,  DLR Cologne, Germany
  • Marcel Egli, Sonia Vadrucci Space Biology Group, ETH Zurich, Switzerland
  • Augusto Cogoli, Marianne Cogoli-Greuter, Zero-G LifeTec GmbH, Switzerland 
  • Francesco Curcio, Department of Pathology and Experimental Medicine, University of Udine, Italy
  • Sarah Baatout, Belgian Nuclear Research Center Mol, Belgium  
  • Jack van Loon, DESC (Dutch Experiment Support Center). ACTA-Free University, Dept. Oral Cell Biology, The Netherlands
  • Theo Baltz, Nicolas Plazolles, Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, Université Bordeaux, France  
  • Hanns-Christian Gunga, ZWMB, Berlin, Germany
  • Johann Schönberger, Jirka Grosse, Department of Nuclear Medicine, University of Regensburg, Germany 
  • Johann Bauer, Max-Planck Institute for Biochemistry, Martinsried-Planegg, near Munich,  Germany
  • Gerhard Weber, FFE Service GmbH, Munich, Germany 
  • Albert Sickmann, Institute for Analytical Sciences, Dortmund, Germany
  • Markus Braun, Nicole Vagt, Institute of Molecular Physiology and Biotechnology of the plants (IMBIO), University of Bonn, Germany
  • Peter Richter, Michael Lebert, Stefanie Wohllebe, Martin Schuster, Institute of Cell Biology, Friedrich-Alexander-University Erlangen-Nürnberg, Germany
  • Norbert Hübner, Katrin Saar, Herbert Schulz, Medical Genomics and Genetics, MDC Berlin, Germany
  • Reinhold Kreutz, Clinical Pharmacology and Toxicology CCM, Charité Universitätsmedizin Berlin CC4, Germany

RESEARCH GROUP MEMBERS
Postdoc Nils Magnusson, PhD  Xiao Ma, technician Heidi Schou Knudsen
Team in Magdeburg: Professor Manfred Infanger, Dr. Markus Wehland, PhD Jessica Pietsch

 

                                                          

Henvendelse om denne sides indhold: 
Revideret 03.08.2016