Schiessl-lab: Laboratory of Renal Cell Remodeling and Regeneration

The Laboratory of Renal Cell Remodeling and Regeneration focuses on the role of renal cell remodeling in kidney disease and regeneration. Even though the kidney is considered a rather stable organ with a limited cellular turnover rate, we know that it holds a remarkable regenerative capacity to recover from acute kidney injury.

Kidney cell remodeling and regeneration involve a complex interaction of different cell types including epithelial, endothelial, interstitial and immune cells, which is difficult to study in vivo and limited understood.

Intravital 2-photon microscopy of the kidney is a powerful technique to investigate renal function and morphology simultaneously, in real time and at subcellular resolutions. Using serial intravital 2-photon and spinning-disk confocal microscopy of the same mouse kidneys over several days and weeks, our lab is able to track individual renal cells and regenerative processes over time and to identify and investigate underlying crosstalk between different cell types.

We aim to identify novel mechanisms of renal cell remodeling and translate this knowledge into new treatment strategies for chronic kidney disease. To achieve this goal, we combine multidisciplinary state-of-the-art techniques, such as advanced imaging techniques, transgenic mouse lines and disease models, fluorescent activated cell sorting and sequencing techniques.

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