Biofilm-producing bacteria constitutes a significant health concern as 80% of all chronic infections are either related to or caused by both biofilm formation and biofilm-mediated resistance to antimicrobial and antibiotic therapies. The structural components of bacterial biofilms are aggregated proteins known as functional bacterial amyloids (FuBA). Occurrence of FuBA in the biofilm renders the biofilm impossible to disassemble. Our research activities are focused on understanding the molecular mechanisms involved in the formation of FuBA, the structure of the FuBA and how the structure is related to the function of FuBA.

We use biophysical techniques to investigate the kinetics of functional amyloid formation, the structure of the formed amyloids and how the process is adapting to changes in the environment. 

Our lab is a part of the Infection and Inflammation Research Theme at the Department of Biomedicine at Aarhus University.