Publications
Gómez-Sánchez, R., Chumpen Ramirez, S., Vargas Duarte, P., Hu, Y., Mari, M., Olschewski, K., Hardenberg, R., Fromme, J. C., Ungermann, C. & Reggiori, F. (2025). Establishment of the phagophore-ERES membrane contact site initiates phagophore elongation. Nature Structural and Molecular Biology, 32(11), 2319-2334. https://doi.org/10.1038/s41594-025-01621-6
Cong, Y., Verlhac, P., Green, B. B., de Vries-Idema, J., Strauss, L. M., Río-Bergé, C., Etzerodt, A., Nejsum, L. N., Huckriede, A. L. W. & Reggiori, F. (2025). Influenza A virus subverts the LC3-pericentrin dynein adaptor complex for host cytoplasm entry. Science Advances, 11(24), Article eadu7602. https://doi.org/10.1126/sciadv.adu7602
Zein, L., Dietrich, M., Balta, D., Bader, V., Scheuer, C., Zellner, S., Weinelt, N., Vandrey, J., Mari, M. C., Behrends, C., Zunke, F., Winklhofer, K. F. & Van Wijk, S. J. L. (2025). Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival. Autophagy, 21(5), 1075-1095. https://doi.org/10.1080/15548627.2024.2443945
Wedman, J. J., de Vries, L., van Lingen, B., van der Zwaag, M., Gómez-Sánchez, R., Hardenberg, R., Huibers, W., Permentier, H., Strauss, E., Chang, M., Reggiori, F., de Kroon, A. I., Sibon, O. C. M. & Schepers, H. (2025). Opt1 imports CoA precursors as glutathione mixed disulfides. The Journal of Biological Chemistry, 301(9), Article 110503. https://doi.org/10.1016/j.jbc.2025.110503
Thorup, C. V., Jeppesen, C. N. A., Jensen, T. H., Tinggaard, A. B., Hvas, C. L., Rud, C. L., Skou, M. K., Mortensen, J. K., Reggiori, F., Dengjel, J., Wang, J., Farup, J., Jessen, N., Kim, W. Y. & Wiggers, H. (2025). POLYamine treatment in elderly patients with Coronary Artery Disease (POLYCAD): study protocol for a Danish randomised, double-blind, placebo-controlled trial of spermidine treatment versus placebo. Current Controlled Trials in Cardiovascular Medicine, 26(1), Article 452. https://doi.org/10.1186/s13063-025-09176-z
Nair, U., Jotwani, A., Geng, J., Gammoh, N., Richerson, D., Yen, W.-L., Griffith, J., Nag, S., Wang, K., Moss, T., Baba, M., McNew, J. A., Jiang, X., Reggiori, F., Melia, T. J. & Klionsky, D. J. (2025). SNARE Proteins Are Required for Macroautophagy. Cell, 188(23), 6687. https://doi.org/10.1016/j.cell.2025.10.018
Zhang, B.-C., Pedersen, A., Reinert, L. S., Li, Y., Narita, R., Idorn, M., Hu, L., Skouboe, M. K., Li, S., Maimaitili, M., Ding, X., Cong, Y., Zhao, J., Frémond, M.-L., Mikkelsen, K., Gao, Z., Huang, J.-R., Thomsen, E. A., Mikkelsen, J. H. ... Paludan, S. R. (2025). STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor. Nature Immunology, 26(11), 1916-1930. https://doi.org/10.1038/s41590-025-02283-8
Filali-Mouncef, Y., Leytens, A., Vargas Duarte, P., Zampieri, M., Dengjel, J. & Reggiori, F. (2024). An APEX2-based proximity-dependent biotinylation assay with temporal specificity to study protein interactions during autophagy in the yeast Saccharomyces cerevisiae. Autophagy, 20(10), 2323-2337. https://doi.org/10.1080/15548627.2024.2366749
Tan, Y., Lai, T., Li, Y., Tang, Q., Zhang, W., Liu, Q., Wu, S., Peng, X., Sui, X., Reggiori, F., Jiang, X., Chen, Q. & Wang, C. (2024). An oil-in-gel type of organohydrogel loaded with methylprednisolone for the treatment of secondary injuries following spinal cord traumas. Journal of Controlled Release, 374, 505-524. https://doi.org/10.1016/j.jconrel.2024.08.033
Aguilera, M. O., Delgui, L. R., Reggiori, F., Romano, P. S. & Colombo, M. I. (2024). Autophagy as an innate immunity response against pathogens: a Tango dance. FEBS Letters, 598(1), 140-166. https://doi.org/10.1002/1873-3468.14788
Barz, S., Hofmann, K., Reggiori, F. & Kraft, C. (2024). Beyond the C-terminal glycine of ATG8 proteins - The story of some neglected amino acids. Journal of Molecular Biology, 436(15), 168588. Article 168588. https://doi.org/10.1016/j.jmb.2024.168588
Bhattacharya, A., Torggler, R., Reiter, W., Romanov, N., Licheva, M., Ciftci, A., Mari, M., Kolb, L., Kaiser, D., Reggiori, F., Ammerer, G., Hollenstein, D. M. & Kraft, C. (2024). Decoding the function of Atg13 phosphorylation reveals a role of Atg11 in bulk autophagy initiation. EMBO Reports, 25(2), 813-831. https://doi.org/10.1038/s44319-023-00055-9
Cóppola Segovia, V. & Reggiori, F. (2024). Molecular insights into aggrephagy: Their cellular functions in the context of neurodegenerative diseases. Journal of Molecular Biology, 436(15), Article 168493. https://doi.org/10.1016/j.jmb.2024.168493
Kraft, C. & Reggiori, F. (2024). Phagophore closure, autophagosome maturation and autophagosome fusion during macroautophagy in the yeast Saccharomyces cerevisiae. FEBS Letters, 598(1), 73-83. https://doi.org/10.1002/1873-3468.14720
Wang, C., Zhang, B., Cong, Y., Du, X., Chen, S., Visser, L., Ruiz-Moreno, A., Zhang, L., Reggiori, F., Alexander, D. & Groves, M. R. (2024). Small-Molecule Allosteric Inhibitors of Human Aspartate Transcarbamoylase Suppress Proliferation of Bone Osteosarcoma Epithelial Cells. ChemMedChem, 19(13), e202300688. Article e202300688. https://doi.org/10.1002/cmdc.202300688
Füllbrunn, N., Nicastro, R., Mari, M., Griffith, J., Herrmann, E., Rasche, R., Borchers, A.-C., Auffarth, K., Kümmel, D., Reggiori, F., De Virgilio, C., Langemeyer, L. & Ungermann, C. (2024). The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes. The Journal of Cell Biology, 223(6), Article e202305038. https://doi.org/10.1083/jcb.202305038
Chumpen Ramirez, S., Gómez-Sánchez, R., Verlhac, P., Hardenberg, R., Margheritis, E., Cosentino, K., Reggiori, F. & Ungermann, C. (2023). Atg9 interactions via its transmembrane domains are required for phagophore expansion during autophagy. Autophagy, 19(5), 1459-1478. https://doi.org/10.1080/15548627.2022.2136340
Mauthe, M., Kampinga, H. H., Hipp, M. S. & Reggiori, F. (2023). Digest it all: the lysosomal turnover of cytoplasmic aggregates. Trends in Biochemical Sciences, 48(3), 216-228. https://doi.org/10.1016/j.tibs.2022.09.012
Río-Bergé, C., Cong, Y. & Reggiori, F. (2023). Getting on the right track: Interactions between viruses and the cytoskeletal motor proteins. Traffic, 24(3), 114-130. https://doi.org/10.1111/tra.12835
Foronda, H., Fu, Y., Covarrubias-Pinto, A., Bocker, H. T., González, A., Seemann, E., Franzka, P., Bock, A., Bhaskara, R. M., Liebmann, L., Hoffmann, M. E., Katona, I., Koch, N., Weis, J., Kurth, I., Gleeson, J. G., Reggiori, F., Hummer, G., Kessels, M. M. ... Hübner, C. A. (2023). Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy. Nature, 618(7964), 402-410. https://doi.org/10.1038/s41586-023-06090-9