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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.
Cell Metabolism,
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Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.
Cell Metabolism,
28(6), 881-894.e13.
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Role of glutamine synthetase in angiogenesis beyond glutamine synthesis.
Nature,
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Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.
Cell Metabolism,
28(4), 573-587.e13.
https://doi.org/10.1016/j.cmet.2018.06.009
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Interaction of endothelial cells with macrophages-linking molecular and metabolic signaling.
Pflügers Archiv - European Journal of Physiology,
469(3-4), 473-483.
https://doi.org/10.1007/s00424-017-1946-6
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Role of glutamine and interlinked asparagine metabolism in vessel formation.
The EMBO Journal,
36(16), 2334-2352.
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The role of fatty acid β-oxidation in lymphangiogenesis.
Nature,
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Tumor vessel disintegration by maximum tolerable PFKFB3 blockade.
Angiogenesis,
20(4), 599-613.
https://doi.org/10.1007/s10456-017-9573-6
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Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.
Cancer Cell,
30(6), 968-985.
https://doi.org/10.1016/j.ccell.2016.10.006
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& Carmeliet, P. (2016).
Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities.
EMBO Molecular Medicine,
8(10), 1134-1142.
https://doi.org/10.15252/emmm.201606798
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Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen.
Cell Reports,
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https://doi.org/10.1016/j.celrep.2015.11.005
Fischer, M. J. M., Soller, K. J., Sauer, S. K.
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Formalin evokes calcium transients from the endoplasmatic reticulum.
PLOS ONE,
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https://doi.org/10.1371/journal.pone.0123762
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Kidney injury is independent of endothelial HIF-1α.
Journal of Molecular Medicine,
93(8), 891-904.
https://doi.org/10.1007/s00109-015-1264-4
Kalucka, J., Missiaen, R., Georgiadou, M., Schoors, S.
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Metabolic control of the cell cycle.
Cell Cycle,
14(21), 3379-88.
https://doi.org/10.1080/15384101.2015.1090068
Mamlouk, S.
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Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.
International Journal of Cancer,
134(4), 849-58.
https://doi.org/10.1002/ijc.28409
Franke, K.
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HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.
Blood,
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https://doi.org/10.1182/blood-2012-08-449181