Selected publications

  1. Paludan SR, Mogensen TH. Innate immunological pathways in COVID-19 pathogenesis. Science Immunology. 2022;7:eabm5505.
  2. Reinert LS, Rashidi AS, Tran DN, et al… , Paludan SR. Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I interferon production. 2021. Journal of Clinical Investigation. 131:e136824.
  3. Paludan SR, Pradeu T, Master S, Mogensen TH. Constitutive immune mechanisms: mediators of host defence and immune regulation. Nature Reviews Immunology. 2021. 21:137-150.
  4. Zhang BC, Nandakumar R*, Reinert LS*, et al…, Paludan SR. STEEP mediates STING ER exit and activation of signaling. Nature Immunology. 2020. 21:868-879.
  5. Bodda C, Reinert LS, Fruhwürth S, et al… Paludan SR. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. The Journal of Experimental Medicine. 2020. 217:e20191422.
  6. Nandakumar R, Tschismarov R, Meissner F, et al… Paludan SR. Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling. Nature Microbiology. 2019. 4:701-713.
  7. Paludan SR, Reinert LS, Hornung V. DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer. Nature Reviews Immunology. 2019. 19:141-153.
  8. Prabakaran T, Bodda C, Krapp C, et al…, Paludan SR. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. The EMBO Journal. 2018 Apr 13;37(8):e97858.
  9. Christensen MH, Jensen SB, Miettinen JJ, et al…, Paludan SR. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. The EMBO Journal. 2016. 35:1385-99.
  10. Reinert LS, Lopušná K, Winther H, et al…, Paludan SR. Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defense in the CNS. Nature Communications. 2016. 7:13348.
  11. Holm CK, Rahbek SH, Gad HH, et al…, Paludan SR. Influenza A virus targets a cGAS independent pathway for STING, which contributes to control of RNA viruses. Nature Communications. 2016. 7:10680.
  12. Iversen MB, Reinert LS, Thomsen MK, et al…, Paludan SR. An innate antiviral pathway acting prior to interferons at epithelial surfaces. Nature Immunology. 2016. 17:150-8.
  13. Hansen K, Prabakaran T, Laustsen A, et al…, Paludan SR. Listeria monocytogenes induces interferon β expression through a pathway dependent on IFI16, cGAS, and STING. The EMBO Journal. 2014. 33:1654-66.
  14. Jakobsen MR, Andersen A, Bak RO, et al…, Paludan SR. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. PNAS. 2013. 110:E4571-80.
  15. Paludan SR, Bowie AG. Immune sensing of DNA. Immunity. 2013. 38:870-80.