Selected publications

  1. Ren F, Narita R, Rashidi AS, Fruhwürth S, Gao Z, Bak RO, Thomsen MK, Verjans GM, Reinert LS, Paludan SR. ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2. EMBO J. 2023. 30:e113118.
  2. Fruhwürth S, Reinert LS, Öberg C, Sakr M, Henricsson M, Zetterberg H, Paludan SR. TREM2 is downregulated by HSV1 in microglia and involved in antiviral defense in the brain. 2023. Science Advances. 9:eadf5808.
  3. Paludan SR, Mogensen TH. Innate immunological pathways in COVID-19 pathogenesis. Science Immunology. 2022;7:eabm5505.
  4. Reinert LS, Rashidi AS, Tran DN, et al… , Paludan SR. Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I interferon production. 2021. Journal of Clinical Investigation. 131:e136824.
  5. Paludan SR, Pradeu T, Master S, Mogensen TH. Constitutive immune mechanisms: mediators of host defence and immune regulation. Nature Reviews Immunology. 2021. 21:137-150.
  6. Zhang BC, Nandakumar R*, Reinert LS*, et al…, Paludan SR. STEEP mediates STING ER exit and activation of signaling. Nature Immunology. 2020. 21:868-879.
  7. Bodda C, Reinert LS, Fruhwürth S, et al… Paludan SR. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. The Journal of Experimental Medicine. 2020. 217:e20191422.
  8. Nandakumar R, Tschismarov R, Meissner F, et al… Paludan SR. Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling. Nature Microbiology. 2019. 4:701-713.
  9. Paludan SR, Reinert LS, Hornung V. DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer. Nature Reviews Immunology. 2019. 19:141-153.
  10. Prabakaran T, Bodda C, Krapp C, et al…, Paludan SR. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. The EMBO Journal. 2018 Apr 13;37(8):e97858.
  11. Christensen MH, Jensen SB, Miettinen JJ, et al…, Paludan SR. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. The EMBO Journal. 2016. 35:1385-99.
  12. Reinert LS, Lopušná K, Winther H, et al…, Paludan SR. Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defense in the CNS. Nature Communications. 2016. 7:13348.
  13. Holm CK, Rahbek SH, Gad HH, et al…, Paludan SR. Influenza A virus targets a cGAS independent pathway for STING, which contributes to control of RNA viruses. Nature Communications. 2016. 7:10680.
  14. Iversen MB, Reinert LS, Thomsen MK, et al…, Paludan SR. An innate antiviral pathway acting prior to interferons at epithelial surfaces. Nature Immunology. 2016. 17:150-8.
  15. Hansen K, Prabakaran T, Laustsen A, et al…, Paludan SR. Listeria monocytogenes induces interferon β expression through a pathway dependent on IFI16, cGAS, and STING. The EMBO Journal. 2014. 33:1654-66.
  16. Jakobsen MR, Andersen A, Bak RO, et al…, Paludan SR. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. PNAS. 2013. 110:E4571-80.
  17. Paludan SR, Bowie AG. Immune sensing of DNA. Immunity. 2013. 38:870-80.