1. Idorn M, Ding X, Fruhwürth S, Holste S, Reinert LS, […] Paludan SR. Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity. J Exp Med. 2026 Jan 5;223(1):e20250064. doi: 10.1084/jem.20250064. Epub 2025 Oct 9. PMID: 41065760.
2. Zhang BC, Pedersen A, Reinert LS, Li Y, Narita R, […] Paludan SR. STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor. Nat Immunol. 2025 Sep 19. doi: 10.1038/s41590-025-02283-8. PMID: 40973797.
3. Dai Y, Idorn M, Serrero MC, Pan X, Thomsen EA, […] Paludan SR. TMEFF1 is a neuron-specific restriction factor for herpes simplex virus. Nature. 2024 Aug;632(8024):383-389. doi: 10.1038/s41586-024-07670-z. PMID: 39048823.
4. Chan YH, Liu Z, Bastard P, Khobrekar N, Hutchison KM, et al. Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature. 2024 Aug;632(8024):390-400. doi: 10.1038/s41586-024-07745-x. PMID: 39048830.
5. Ren F, Narita R, Rashidi AS, Fruhwürth S, Gao Z, Bak RO, Thomsen MK, Verjans GM, Reinert LS, Paludan SR. ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2. EMBO J. 2023. 30:e113118. doi: 10.15252/embj.2022113118. PMID: 37646198.
6. Fruhwürth S, Reinert LS, Öberg C, Sakr M, Henricsson M, Zetterberg H, Paludan SR. TREM2 is downregulated by HSV1 in microglia and involved in antiviral defense in the brain. 2023. Science Advances. 9:eadf5808.
7. Paludan SR, Mogensen TH. Innate immunological pathways in COVID-19 pathogenesis. Science Immunology. 2022; 7:eabm5505.
8. Reinert LS, Rashidi AS, Tran DN, et al… , Paludan SR. Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I interferon production. 2021. Journal of Clinical Investigation. 131:e136824.
9. Paludan SR, Pradeu T, Master S, Mogensen TH. Constitutive immune mechanisms: mediators of host defence and immune regulation. Nature Reviews Immunology. 2021. 21:137-150.
10. Zhang BC, Nandakumar R*, Reinert LS*, et al…, Paludan SR. STEEP mediates STING ER exit and activation of signaling. Nature Immunology. 2020. 21:868-879.
11. Bodda C, Reinert LS, Fruhwürth S, et al… Paludan SR. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. The Journal of Experimental Medicine. 2020. 217:e20191422.
12. Nandakumar R, Tschismarov R, Meissner F, et al… Paludan SR. Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling. Nature Microbiology. 2019. 4:701-713.
13. Paludan SR, Reinert LS, Hornung V. DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer. Nature Reviews Immunology. 2019. 19:141-153.
14. Reinert LS, Lopušná K, Winther H, et al…, Paludan SR. Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defense in the CNS. Nature Communications. 2016. 7:13348.
15. Iversen MB, Reinert LS, Thomsen MK, et al…, Paludan SR. An innate antiviral pathway acting prior to interferons at epithelial surfaces. Nature Immunology. 2016. 17:150-8.
16. Paludan SR, Bowie AG. Immune sensing of DNA. Immunity. 2013. 38:870-80.

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