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In vitro ovarian tumor-conditioned CD163+ human macrophages retain phagocytic response to CD47 blockade.
Cellular Immunology,
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LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling.
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Pluronic Acid Prevents Sorter-Induced Cell Stress in Myeloid Cells From Mouse Peritoneal Cavity.
Cytometry Part A,
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Prognostic value of CD163+ macrophages in solid tumor malignancies: A scoping review. Immunology Letters,
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CD163+ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier.
The Journal of Experimental Medicine,
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Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds.
Nature Communications,
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Reynders, A., Anissa Jhumka, Z., Gaillard, S., Mantilleri, A., Malapert, P., Magalon, K.
, Etzerodt, A., Salio, C., Ugolini, S., Castets, F., Saurin, A. J., Serino, M., Hoeffel, G. & Moqrich, A. (2024).
Gut microbiota promotes pain chronicity in Myosin1A deficient male mice.
Brain, Behavior, and Immunity,
119, 750-766.
https://doi.org/10.1016/j.bbi.2024.05.010Mikkelsen, J. H., Stødkilde, K., Jensen, M. P., Hansen, A. G., Wu, Q., Lorentzen, J., Graversen, J. H.
, Andersen, G. R., Fenton, R. A., Etzerodt, A., Thiel, S. & Andersen, C. B. F. (2024).
Trypanosoma brucei Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis.
Journal of Immunology,
212(8), 1334-1344.
https://doi.org/10.4049/jimmunol.2300862
Antonsen, K. W., Jensen, A. G., Carstensen, M., Nejsum, L. N., Sorensen, B. S., Etzerodt, A., Moestrup, S. K. & Møller, H. J. (2024).
Proinflammatory polarization strongly reduces human macrophage in vitro phagocytosis of tumor cells in response to CD47 blockade.
European Journal of Immunology,
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Etzerodt, A., Mikkelsen, J. H., Torvund-Jensen, M., Hennig, D.
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The Cryo-EM structure of human CD163 bound to haptoglobin-hemoglobin reveals molecular mechanisms of hemoglobin scavenging.
Nature Communications,
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https://doi.org/10.1038/s41467-024-55171-4
Antonsen, K. W., Friis, H. N., Sorensen, B. S., Etzerodt, A., Moestrup, S. K. & Møller, H. J. (2023).
Comparison of culture media reveals that non-essential amino acids strongly affect the phenotype of human monocyte-derived macrophages.
Immunology,
170(3), 344-358.
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van Elsas, M. J., Labrie, C.
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Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy.
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Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson's disease.
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T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy.
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STAT3 is over-activated within CD163pos bone marrow macrophages in both Multiple Myeloma and the benign pre-condition MGUS.
Cancer Immunology, Immunotherapy,
71(1), 177-187.
https://doi.org/10.1007/s00262-021-02952-1
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Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer.
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Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease.
Movement Disorders,
36(4), 963-976.
https://doi.org/10.1002/mds.28424
Etzerodt, A., Moulin, M., Doktor, T. K., Delfini, M., Mossadegh-Keller, N., Bajenoff, M., Sieweke, M. H.
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Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer.
The Journal of Experimental Medicine,
217(4), Article e20191869.
https://doi.org/10.1084/jem.20191869
Goossens, P., Rodriguez-Vita, J.
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Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression.
Cell Metabolism,
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, Graversen, J. H., Auphan-Anezin, N.
, Moestrup, S. K. & Lawrence, T. (2019).
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.
The Journal of Experimental Medicine,
216(10), 2394-2411.
https://doi.org/10.1084/jem.20182124
Andersen, M. N., Etzerodt, A., Graversen, J. H., Holthof, L. C.
, Moestrup, S. K., Hokland, M. & Møller, H. J. (2019).
STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes.
Cancer Immunology, Immunotherapy,
68(3), 489-502.
https://doi.org/10.1007/s00262-019-02301-3
Rafique, A., Etzerodt, A., Graversen, J. H.
, Moestrup, S. K., Dagnæs-Hansen, F. & Møller, H. J. (2019).
Targeted lipid nanoparticle delivery of calcitriol to human monocyte-derived macrophages in vitro and in vivo: Investigation of the anti-inflammatory effects of calcitriol.
International Journal of Nanomedicine,
14, 2829-2846.
https://doi.org/10.2147/IJN.S192113
Nielsen, M. C., Andersen, M. N., Rittig, N., Rødgaard-Hansen, S., Grønbaek, H., Moestrup, S. K., Møller, H. J. & Etzerodt, A. (2019).
The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms.
Journal of Leukocyte Biology,
106(5), 1129-1138.
https://doi.org/10.1002/JLB.3A1218-500R
Nielsen, M. C., Andersen, M. N., Rittig, N., Rødgaard-Hansen, S., Grønbæk, H., Moestrup, S. K., Møller, H. J. & Etzerodt, A. (2018).
Different shedding mechanisms of the macrophage-related biomarkers sMR and sCD163. Poster session presented at Keystone Symposium: Myeloid Cells, Breckenridge, Colorado, United States.
Larsen, C., Etzerodt, A., Madsen, M., Skjødt, K.
, Moestrup, S. K. & Andersen, C. B. F. (2018).
Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption.
Nature Communications,
9(1), Article 5204.
https://doi.org/10.1038/s41467-018-07468-4
Svendsen, P., Graversen, J. H., Etzerodt, A., Hager, H., Røge, R.
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Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes.
Molecular Therapy Methods and Clinical Development,
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https://doi.org/10.1016/j.omtm.2016.11.004
Etzerodt, A., Berg, R. M. G., Plovsing, R. R.
, Andersen, M. N., Bebien, M., Habbeddine, M., Lawrence, T.
, Møller, H. J. & Moestrup, S. K. (2017).
Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of 'soluble CD163' in plasma.
Scientific Reports,
7, 40286. Article 40286.
https://doi.org/10.1038/srep40286
Nielsen, M. A., Andersen, T., Etzerodt, A., Kragstrup, T. W., Rasmussen, T. K., Stengaard-Pedersen, K., Hetland, M. L., Hørslev-Petersen, K., Junker, P., Østergaard, M.
, Hvid, M., Moestrup, S. K.
& Deleuran, B. (2016).
A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4-1BB activity and disease outcome in rheumatoid arthritis.
Rheumatology,
55(10), 1871-1879. Article kew237.
https://doi.org/10.1093/rheumatology/kew237
Tentillier, N., Etzerodt, A., Olesen, M. N., Rizalar, F. S., Jacobsen, J., Bender, D., Moestrup, S. K. & Romero-Ramos, M. (2016).
Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model.
The Journal of neuroscience,
36(36), 9375-90.
https://doi.org/10.1523/JNEUROSCI.1636-16.2016
Andersen, M. N., Etzerodt, A., Maniecki, M. B., Moestrup, S. K., Hokland, M.
& Møller, H. J. (2016).
Liposome-based targeting of a STAT3-inhibitor to Tumor-Associated Macrophages. Poster session presented at Keystone Symposium: Cancer Pathophysiology. Integrating the Host and Tumor Environments, Breckenridge, CO, United States.
Saederup, K. L.
, Stødkilde-Jørgensen, K., Graversen, J. H., Dickson, C. F.
, Etzerodt, A., Hansen, S. W. K.
, Fago, A., Gell, D.
, Andersen, C. B. F. & Moestrup, S. K. (2016).
The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen.
Journal of Biological Chemistry,
291(46), 23989-23998.
https://doi.org/10.1074/jbc.M116.755934Jepsen, B. N.
, Andersen, K. J., Knudsen, A. R., Nyengaard, J. R., Hamilton-Dutoit, S., Svendsen, P., Etzerodt, A., Møller, H. J., Moestrup, S. K., Graversen, J. H. & Mortensen, F. V. (2015).
Anti-inflammatory liposomes have no impact on liver regeneration in rats.
Annals of Medicine and Surgery,
4(4), 452-461.
https://doi.org/10.1016/j.amsu.2015.10.018Andersen, M. N., Etzerodt, A., Maniecki, M. B., Andersen, N. F., Moestrup, S. K., Hokland, M. & Møller, H. J. (2015).
LIPOSOME-BASED SPECIFIC TARGETING OF A STAT3-INHIBITOR TO CANCER-PROMOTING MACROPHAGES: A NOVEL THERAPUTIC PARADIGM IN MULTIPLE MYELOMA. Poster session presented at EHA 2015: 20th Congress of the European Hematology Association, Vienna, Austria.
Etzerodt, A., Rasmussen, M. R., Svendsen, P., Chalaris, A., Schwarz, J., Galea, I.
, Moller, H. J. & Moestrup, S. K. (2014).
Structural Basis for inflammation-Driven Shedding of CD163 and Tumor Necrosis Factor-α in Macrophages.
Journal of Biological Chemistry,
289, 778-788.
https://doi.org/10.1074/jbc.M113.520213
Orr, J. S., Kennedy, A., Anderson-Baucum, E. K., Webb, C. D., Fordahl, S. C., Erikson, K. M., Zhang, Y.
, Etzerodt, A., Moestrup, S. K. & Hasty, A. H. (2013).
Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution.
Diabetes.
https://doi.org/10.2337/db13-0213Etzerodt, A., Kjolby, M., Nielsen, M. J., Maniecki, M. B., Svendsen, P. & Moestrup, S. K. (2013).
Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption.
Antioxidants & Redox Signaling,
18(17), 2254-2263.
https://doi.org/10.1089/ars.2012.4605
Granfeldt, A., Hvas, C. L., Graversen, J. H., Christensen, P. A., Petersen, M. D., Anton, G.
, Svendsen, P., Sølling, C., Etzerodt, A., Tønnesen, E., Moestrup, S. K. & Møller, H. J. (2013).
Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model.
Critical Care Medicine,
41(11), e309-e318.
https://doi.org/10.1097/CCM.0b013e31828a45ef
Etzerodt, A., Maniecki, M. B., Graversen, J. H.
, Møller, H. J., Torchilin, V. P.
& Moestrup, S. K. (2012).
Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163.
Journal of Controlled Release.
https://doi.org/10.1016/j.jconrel.2012.01.034
Graversen, J. H., Svendsen, P., Dagnæs-Hansen, F., Dal, J., Anton, G.
, Etzerodt, A., Petersen, M. D., Christensen, P. A., Møller, H. J. & Moestrup, S. K. (2012).
Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone.
Molecular Therapy.
https://doi.org/10.1038/mt.2012.103
Maniecki, M. B., Etzerodt, A., Ulhøi, B. P., Steiniche, T., Borre, M., Andersen, L. D., Orntoft, T. F., Moestrup, S. K. & Møller, H. J. (2012).
Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells.
International Journal of Cancer,
131(10), 2320-2331.
https://doi.org/10.1002/ijc.27506
Maniecki, M. B., Etzerodt, A., Moestrup, S. K., Møller, H. J. & Graversen, J. H. (2011).
Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression.
Immunobiology,
216, 882-890.
https://doi.org/10.1016/j.imbio.2011.02.001