Publications

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Zurawska, G., Sas, Z., Jończy, A., Mahadeva, R., Slusarczyk, P., Chwałek, M., Seehofer, D., Damm, G., Mazgaj, R., Skórzyński, M., Kulecka, M., Rumieńczyk, I., Moulin, M., Jastrzębski, K., Waldron, K., Mikula, M., Etzerodt, A., Serwa, R., Miączyńska, M. ... Mleczko-Sanecka, K. (2026). Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance. EMBO Reports, 27(3), 598-628. https://doi.org/10.1038/s44319-025-00673-5

Zhang, B.-C., Laursen, M. F., Hu, L., Hazrati, H., Narita, R., Jensen, L. S., Hansen, A. S., Huang, J., Zhang, Y., Ding, X., Muyesier, M., Nilsson, E., Banasik, A., Zeiler, C., Mogensen, T. H., Etzerodt, A., Agger, R., Johannsen, M., Kofod-Olsen, E. ... Jakobsen, M. R. (2024). Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds. Nature Communications, 15(1), Article 2760. https://doi.org/10.1038/s41467-024-47046-5

van Elsas, M. J., Labrie, C., Etzerodt, A., Charoentong, P., van Stigt Thans, J. J. C., Van Hall, T. & van der Burg, S. H. (2023). Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy. Journal for ImmunoTherapy of Cancer, 11(3), Article e006433. https://doi.org/10.1136/jitc-2022-006433

Thomsen, J. H., Etzerodt, A., Svendsen, P. & Moestrup, S. K. (2013). The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging. Oxidative Medicine and Cellular Longevity, 2013, 523652. https://doi.org/10.1155/2013/523652

Tentillier, N., Etzerodt, A., Olesen, M. N., Rizalar, F. S., Jacobsen, J., Bender, D., Moestrup, S. K. & Romero-Ramos, M. (2016). Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model. The Journal of neuroscience, 36(36), 9375-9390. https://doi.org/10.1523/JNEUROSCI.1636-16.2016

Svendsen, P., Graversen, J. H., Etzerodt, A., Hager, H., Røge, R., Grønbæk, H., Christensen, E. I., Møller, H. J., Vilstrup, H. & Moestrup, S. K. (2017). Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes. Molecular Therapy Methods and Clinical Development, 4, 50-61. https://doi.org/10.1016/j.omtm.2016.11.004

Svendsen, P., Etzerodt, A., Deleuran, B. W. & Moestrup, S. K. (2020). Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis. Scientific Reports, 10, Article 12447. https://doi.org/10.1038/s41598-020-69018-7

Saederup, K. L., Stødkilde-Jørgensen, K., Graversen, J. H., Dickson, C. F., Etzerodt, A., Hansen, S. W. K., Fago, A., Gell, D., Andersen, C. B. F. & Moestrup, S. K. (2016). The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen. Journal of Biological Chemistry, 291(46), 23989-23998. https://doi.org/10.1074/jbc.M116.755934

Reynders, A., Anissa Jhumka, Z., Gaillard, S., Mantilleri, A., Malapert, P., Magalon, K., Etzerodt, A., Salio, C., Ugolini, S., Castets, F., Saurin, A. J., Serino, M., Hoeffel, G. & Moqrich, A. (2024). Gut microbiota promotes pain chronicity in Myosin1A deficient male mice. Brain, Behavior, and Immunity, 119, 750-766. https://doi.org/10.1016/j.bbi.2024.05.010

Rasmussen, R. K. & Etzerodt, A. (2021). Therapeutic targeting of tumor-associated macrophages. In Advances in Immunopharmacology (pp. 185-211). Academic Press. https://doi.org/10.1016/bs.apha.2021.03.002

Rasmussen, M. Q., Bønnelykke-Behrndtz, M. L., Merrild, C., Tvilling, I. K. S., Christensen, J. N., Nielsen, M. M., Georgsen, J. B., Naumann, N., Gudbergsson, J. M., Etzerodt, A., Pedersen, J. S., Jenkins, R. W., Degn, S. E., Moestrup, S. K., Schmidt, H., Steiniche, T. & Madsen, M. (2025). LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling. Pigment Cell & Melanoma Research, 38(5), Article e70053. https://doi.org/10.1111/pcmr.70053

Rafique, A., Etzerodt, A., Graversen, J. H., Moestrup, S. K., Dagnæs-Hansen, F. & Møller, H. J. (2019). Targeted lipid nanoparticle delivery of calcitriol to human monocyte-derived macrophages in vitro and in vivo: Investigation of the anti-inflammatory effects of calcitriol. International Journal of Nanomedicine, 14, 2829-2846. https://doi.org/10.2147/IJN.S192113

Orr, J. S., Kennedy, A., Anderson-Baucum, E. K., Webb, C. D., Fordahl, S. C., Erikson, K. M., Zhang, Y., Etzerodt, A., Moestrup, S. K. & Hasty, A. H. (2013). Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution. Diabetes. https://doi.org/10.2337/db13-0213

Nissen, S. K., Ferreira, S. A., Nielsen, M. C., Schulte, C., Shrivastava, K., Hennig, D., Etzerodt, A., Graversen, J. H., Berg, D., Maetzler, W., Panhelainen, A., Møller, H. J., Brockmann, K. & Romero-Ramos, M. (2021). Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease. Movement Disorders, 36(4), 963-976. https://doi.org/10.1002/mds.28424

Nielsen, M. A., Andersen, T., Etzerodt, A., Kragstrup, T. W., Rasmussen, T. K., Stengaard-Pedersen, K., Hetland, M. L., Hørslev-Petersen, K., Junker, P., Østergaard, M., Hvid, M., Moestrup, S. K. & Deleuran, B. (2016). A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4-1BB activity and disease outcome in rheumatoid arthritis. Rheumatology, 55(10), 1871-1879. Article kew237. https://doi.org/10.1093/rheumatology/kew237

Nielsen, M. C., Andersen, M. N., Rittig, N., Rødgaard-Hansen, S., Grønbæk, H., Moestrup, S. K., Møller, H. J. & Etzerodt, A. (2018). Different shedding mechanisms of the macrophage-related biomarkers sMR and sCD163. Poster session presented at Keystone Symposium: Myeloid Cells, Breckenridge, Colorado, United States.

Nielsen, M. C., Andersen, M. N., Rittig, N., Rødgaard-Hansen, S., Grønbaek, H., Moestrup, S. K., Møller, H. J. & Etzerodt, A. (2019). The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms. Journal of Leukocyte Biology, 106(5), 1129-1138. https://doi.org/10.1002/JLB.3A1218-500R

Mikkelsen, J. H., Stødkilde, K., Jensen, M. P., Hansen, A. G., Wu, Q., Lorentzen, J., Graversen, J. H., Andersen, G. R., Fenton, R. A., Etzerodt, A., Thiel, S. & Andersen, C. B. F. (2024). Trypanosoma brucei Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis. Journal of Immunology, 212(8), 1334-1344. https://doi.org/10.4049/jimmunol.2300862

Mathiesen, H., Juul-Madsen, K., Tramm, T., Vorup-Jensen, T., Møller, H. J., Etzerodt, A. & Andersen, M. N. (2025). Prognostic value of CD163+ macrophages in solid tumor malignancies: A scoping review. Immunology Letters, 272, 106970. Article 106970. https://doi.org/10.1016/j.imlet.2025.106970

Maniecki, M. B., Etzerodt, A., Moestrup, S. K., Møller, H. J. & Graversen, J. H. (2011). Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression. Immunobiology, 216, 882-890. https://doi.org/10.1016/j.imbio.2011.02.001

Maniecki, M. B., Etzerodt, A., Ulhøi, B. P., Steiniche, T., Borre, M., Andersen, L. D., Orntoft, T. F., Moestrup, S. K. & Møller, H. J. (2012). Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells. International Journal of Cancer, 131(10), 2320-2331. https://doi.org/10.1002/ijc.27506

Lund, H., Hunt, M. A., Kurtović, Z., Sandor, K., Kägy, P. B., Fereydouni, N., Julien, A., Göritz, C., Vazquez-Liebanas, E., Andaloussi Mäe, M., Jurczak, A., Han, J., Zhu, K., Harris, R. A., Lampa, J., Graversen, J. H., Etzerodt, A., Haglund, L., Yaksh, T. L. & Svensson, C. I. (2024). CD163⁺ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier. The Journal of Experimental Medicine, 221(2), Article e20230675. https://doi.org/10.1084/jem.20230675

Larsen, C., Etzerodt, A., Madsen, M., Skjødt, K., Moestrup, S. K. & Andersen, C. B. F. (2018). Structural assembly of the megadalton-sized receptor for intestinal vitamin B₁₂ uptake and kidney protein reabsorption. Nature Communications, 9(1), Article 5204. https://doi.org/10.1038/s41467-018-07468-4

Jepsen, B. N., Andersen, K. J., Knudsen, A. R., Nyengaard, J. R., Hamilton-Dutoit, S., Svendsen, P., Etzerodt, A., Møller, H. J., Moestrup, S. K., Graversen, J. H. & Mortensen, F. V. (2015). Anti-inflammatory liposomes have no impact on liver regeneration in rats. Annals of Medicine and Surgery, 4(4), 452-461. https://doi.org/10.1016/j.amsu.2015.10.018

Hansen, A. S., Jensen, L. S., Gammelgaard, K. R., Ryttersgaard, K. G., Krapp, C., Just, J., Jønsson, K. L., Jensen, P. B., Boesen, T., Johannsen, M., Etzerodt, A., Deleuran, B. W. & Jakobsen, M. R. (2023). T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy. Journal of Extracellular Vesicles, 12(8), Article 12350. https://doi.org/10.1002/jev2.12350

Gustafsen, C., Vilstrup, J., Kristensen, M., Køster, D., Lende, J., Larsen, C., Simonsen, A., Graversen, A., Olsen, D., Pallesen, L. T., Vægter, C. B., Kresse, J.-C., Schou, M., Weyer, K., Etzerodt, A., Palmfeldt, J., Kaas, M., Qureshi, O., Harrison, N. ... Glerup, S. (2026). Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins. Cell Chemical Biology, 33(4), 490-505.e40. https://doi.org/10.1016/j.chembiol.2026.03.002

Guillot, J., Dominici, C., Lucchesi, A., Nguyen, H. T. T., Puget, A., Hocine, M., Rangel-Sosa, M. M., Simic, M., Nigri, J., Guillaumond, F., Bigonnet, M., Dusetti, N., Perrot, J., Lopez, J., Etzerodt, A., Lawrence, T., Pudlo, P., Hubert, F., Scoazec, J.-Y. ... Mann, F. (2022). Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer. Nature Communications, 13(1), Article 1985. https://doi.org/10.1038/s41467-022-29659-w

Gudbergsson, J. M. & Etzerodt, A. (2024). Migrasomes should not be classified as extracellular vesicles. Journal of Cellular and Molecular Medicine, 28(9), e18337. Article e18337. https://doi.org/10.1111/jcmm.18337

Gudbergsson, J. M., Holten-Møller, I., Moulin, M., Keidser-Nilsson, S. J., Wittenborn, T., Bohn, A. B., Petersen, C. C. & Etzerodt, A. (2025). Pluronic Acid Prevents Sorter-Induced Cell Stress in Myeloid Cells From Mouse Peritoneal Cavity. Cytometry Part A, 107(11), 763-769. https://doi.org/10.1002/cyto.a.24968

Graversen, J. H., Svendsen, P., Dagnæs-Hansen, F., Dal, J., Anton, G., Etzerodt, A., Petersen, M. D., Christensen, P. A., Møller, H. J. & Moestrup, S. K. (2012). Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone. Molecular Therapy. https://doi.org/10.1038/mt.2012.103

Granfeldt, A., Hvas, C. L., Graversen, J. H., Christensen, P. A., Petersen, M. D., Anton, G., Svendsen, P., Sølling, C., Etzerodt, A., Tønnesen, E., Moestrup, S. K. & Møller, H. J. (2013). Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model. Critical Care Medicine, 41(11), e309-e318. https://doi.org/10.1097/CCM.0b013e31828a45ef

Goossens, P., Rodriguez-Vita, J., Etzerodt, A., Masse, M., Rastoin, O., Gouirand, V., Ulas, T., Papantonopoulou, O., Van Eck, M., Auphan-Anezin, N., Bebien, M., Verthuy, C., Vu Manh, T. P., Turner, M., Dalod, M., Schultze, J. L. & Lawrence, T. (2019). Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression. Cell Metabolism, 29(6), 1376-1389.e4. https://doi.org/10.1016/j.cmet.2019.02.016

Etzerodt, A., Maniecki, M. B., Møller, K., Møller, H. J. & Moestrup, S. K. (2010). Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163. Journal of Leukocyte Biology, 88(6), 1201-1205.

Etzerodt, A., Maniecki, M. B., Graversen, J. H., Møller, H. J., Torchilin, V. P. & Moestrup, S. K. (2012). Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2012.01.034

Etzerodt, A., Kjolby, M., Nielsen, M. J., Maniecki, M. B., Svendsen, P. & Moestrup, S. K. (2013). Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption. Antioxidants & Redox Signaling, 18(17), 2254-2263. https://doi.org/10.1089/ars.2012.4605

Etzerodt, A. & Moestrup, S. K. (2013). CD163 and inflammation: Biological, diagnostic and therapeutic aspects. Antioxidants & Redox Signaling, 18(17), 2352-2363. https://doi.org/10.1089/ars.2012.4834

Etzerodt, A., Rasmussen, M. R., Svendsen, P., Chalaris, A., Schwarz, J., Galea, I., Moller, H. J. & Moestrup, S. K. (2014). Structural Basis for inflammation-Driven Shedding of CD163 and Tumor Necrosis Factor-α in Macrophages. Journal of Biological Chemistry, 289, 778-788. https://doi.org/10.1074/jbc.M113.520213

Etzerodt, A. & Schafer, R. (2013). Improving delivery with macrophage targeting. Manufacturing Chemist, 84(3), 33-35. http://www.scopus.com/inward/record.url?scp=84891821504&partnerID=8YFLogxK

Etzerodt, A., Berg, R. M. G., Plovsing, R. R., Andersen, M. N., Bebien, M., Habbeddine, M., Lawrence, T., Møller, H. J. & Moestrup, S. K. (2017). Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of 'soluble CD163' in plasma. Scientific Reports, 7, 40286. Article 40286. https://doi.org/10.1038/srep40286

Etzerodt, A., Tsalkitzi, K., Maniecki, M., Damsky, W., Delfini, M., Baudoin, E., Moulin, M., Bosenberg, M., Graversen, J. H., Auphan-Anezin, N., Moestrup, S. K. & Lawrence, T. (2019). Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression. The Journal of Experimental Medicine, 216(10), 2394-2411. https://doi.org/10.1084/jem.20182124

Etzerodt, A., Moulin, M., Doktor, T. K., Delfini, M., Mossadegh-Keller, N., Bajenoff, M., Sieweke, M. H., Moestrup, S. K., Auphan-Anezin, N. & Lawrence, T. (2020). Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer. The Journal of Experimental Medicine, 217(4), Article e20191869. https://doi.org/10.1084/jem.20191869