Publications
Blau, H. M. & Porpiglia, E. (2026). From Cell Reprogramming to Tissue Rejuvenation: Countering Aging by Targeting a Gerozyme. Annual Review of Pharmacology and Toxicology, 66(1), 7-26. https://doi.org/10.1146/annurev-pharmtox-071724-100856
Kang, J., Kanugovi, A., Stella, M. P. J., Frimand, Z., Farup, J., Urtasun, A., Liu, S., Clausen, A.-S., Ishak, H., Bui, S., Kim, S., Ezran, C., Botvinnik, O., Porpiglia, E., Krasnow, M. A., de Morree, A. & Rando, T. A. (2025). In vivo self-renewal and expansion of quiescent stem cells from a non-human primate. Nature Communications, 16(1), Article 5370. https://doi.org/10.1038/s41467-025-58897-x
Porpiglia, E. & Blau, H. (2024). Novel single-cell technologies advance our mechanistic understanding of muscle stem cell function in skeletal muscle regeneration. In W. Fantl (Ed.), Revealing Uncharted Biology With Single Cell Multiplex Proteomic Technologies: Applications (pp. 47-70). Academic Press. https://doi.org/10.1016/B978-0-12-822213-3.00003-6
Andersen, S. H., Kjær, T. R., Ghimire, K. & Porpiglia, E. (2023). Identification and Analysis of Myogenic Progenitors In Vivo During Acute Skeletal Muscle Injury by High-Dimensional Single-Cell Mass Cytometry. Journal of visualized experiments : JoVE, 202(202), Article e65944. https://doi.org/10.3791/65944
Danielli, S. G., Porpiglia, E., De Micheli, A. J., Navarro, N., Zellinger, M. J., Bechtold, I., Kisele, S., Volken, L., Marques, J. G., Kasper, S., Bode, P. K., Henssen, A. G., Gürgen, D., Delattre, O., Surdez, D., Roma, J., Bühlmann, P., Blau, H. M., Wachtel, M. & Schäfer, B. W. (2023). Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance. Science Advances, 9(6), Article eade9238. https://doi.org/10.1126/sciadv.ade9238
Blau, H. M., Porpiglia, E. & Burns, D. (2023). Tsp-1 inhibitors for the treatment of aged, atrophied or dystrophied muscle. (Patent No. US20230220075 (A1)). https://patents.google.com/patent/US20230220075A1/en
Porpiglia, E., Mai, T., Kraft, P., Holbrook, C. A., de Morree, A., Gonzalez, V. D., Hilgendorf, K. I., Frésard, L., Trejo, A., Bhimaraju, S., Jackson, P. K., Fantl, W. J. & Blau, H. M. (2022). Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. Cell Stem Cell, 29(12), 1653-1668.e8. https://doi.org/10.1016/j.stem.2022.10.009
Frimand, Z., Das Barman, S., Kjær, T. R., Porpiglia, E. & de Morree, A. (2022). Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles. Journal of Visualized Experiments, 190, Article e64557. https://doi.org/10.3791/64557
Delgado-Gonzalez, A., Huang, Y.-W., Porpiglia, E., Donoso, K., Gonzalez, V. D. & Fantl, W. J. (2022). Measuring trogocytosis between ovarian tumor and natural killer cells. STAR Protocols, 3(2), Article 101425. https://doi.org/10.1016/j.xpro.2022.101425
Porpiglia, E. & Blau, H. M. (2022). Plasticity of muscle stem cells in homeostasis and aging. Current Opinion in Genetics & Development, 77, Article 101999. https://doi.org/10.1016/j.gde.2022.101999
Danielli, S., Porpiglia, E. & Schafer, B. (2022). Single-cell mapping of tumor heterogeneity in pediatric rhabdomyosarcoma reveals developmental signatures with therapeutic relevance. bioRxiv. https://doi.org/10.1101/2022.04.20.487706
Porpiglia, E. (2022). Single-cell profiling reveals a conserved myogenic hierarchy in pediatric rhabdomyosarcomas amenable to differentiation therapy. Cancer Research, 82(12_supplement). https://doi.org/10.1158/1538-7445.AM2022-1679
Gonzalez, V. D., Huang, Y.-W., Delgado-Gonzalez, A., Chen, S.-Y., Donoso, K., Sachs, K., Gentles, A. J., Allard, G. M., Kolahi, K. S., Howitt, B. E., Porpiglia, E. & Fantl, W. J. (2021). High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment. Cell Reports, 36(9), 109632. Article 109632. https://doi.org/10.1016/j.celrep.2021.109632
Yucel, N., Wang, Y. X., Mai, T., Porpiglia, E., Lund, P. J., Markov, G., Garcia, B. A., Bendall, S. C., Angelo, M. & Blau, H. M. (2019). Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function. Cell Reports, 27(13), 3939-3955.e6. https://doi.org/10.1016/j.celrep.2019.05.092
Porpiglia, E., Samusik, N., Ho, A. T. V., Cosgrove, B. D., Mai, T., Davis, K. L., Jager, A., Nolan, G. P., Bendall, S. C., Fantl, W. J. & Blau, H. M. (2017). High-resolution myogenic lineage mapping by single-cell mass cytometry. Nature Cell Biology, 19(5), 558-567. https://doi.org/10.1038/ncb3507
Koulnis, M., Porpiglia, E., Hidalgo, D. & Socolovsky, M. (2014). Erythropoiesis: from molecular pathways to system properties. Advances in Experimental Medicine and Biology, 844, 37-58. https://doi.org/10.1007/978-1-4939-2095-2_3
Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L. & Blau, H. M. (2014). Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine, 20(3), 255-64. https://doi.org/10.1038/nm.3464
Porpiglia, E. & Blau, H. M. (2013). Adult muscle stem cell isolation.
Koulnis, M., Porpiglia, E., Porpiglia, P. A., Liu, Y., Hallstrom, K., Hidalgo, D. & Socolovsky, M. (2012). Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways. Blood, 119(5), 1228-39. https://doi.org/10.1182/blood-2011-07-365346
Porpiglia, E., Hidalgo, D., Koulnis, M., Tzafriri, A. R. & Socolovsky, M. (2012). Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities. PLoS Biology, 10(8), e1001383. https://doi.org/10.1371/journal.pbio.1001383
