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Broksø AD, Bendixen L, Fammé S, Mikkelsen K, Jensen TI, Bak RO. Orthogonal transcriptional modulation and gene editing using multiple CRISPR/Cas systems. Mol Ther. 2024 Nov 19 Online ahead of print.
Fahlquist-Hagert C, Wittenborn TR, Pedersen MK, Jensen L, Degn SE. T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity. iScience. 2024 Sep.
Greisen SR, Bendix M, Nielsen MA, Pedersen K, Jensen NH, Hvid M, Mikkelsen JH, Drace T, Boesen T, Steiniche T, Schmidt H, Deleuran B. Gal-3 blocks the binding between PD-1 and pembrolizumab. Journal for ImmunoTherapy of Cancer. 2024 Sep.
Nielsen IH, Rovsing AB, Janns JH, Thomsen EA, Ruzo A, Bøggild A, Nedergaard F, Møller CT, Boesen T, Degn SE, Shah JV, Mikkelsen JG. Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles. Mol Ther Nucleic Acids. 2024 Aug.
Dørflinger GH, Holt CB, Thiel S, Bech JN, Østergaard JA, Bjerre M. Mannan-Binding Lectin Is Associated with Inflammation and Kidney Damage in a Mouse Model of Type 2 Diabetes. Int J Mol Sci. 2024 Jun.
Pedersen K, Laursen NS, Hansen AG, Palarasah Y, Thiel S. Development of an immunoassay for quantification of soluble human CD40L (CD154) in plasma and serum samples. J Immunol Methods. 2024 Aug.
Dai Y, Idorn M, Serrero MC, Pan X, Thomsen EA, Narita R, Maimaitili M, Qian X, Iversen MB, Reinert LS, Flygaard RK, Chen M, Ding X, Zhang BC, Carter-Timofte ME, Lu Q, Jiang Z, Zhong Y, Zhang S, Da L, Zhu J, Denham M, Nissen P, Mogensen TH, Mikkelsen JG, Zhang SY, Casanova JL, Cai Y, Paludan SR. TMEFF1 is a neuron-specific restriction factor for herpes simplex virus. Nature. 2024 Aug.
Hybel TE, Jensen SH, Rodrigues MA, Hybel TE, Pedersen MN, Qvick SH, Enemark MH, Bill M, Rosenberg CA, Ludvigsen M. Imaging Flow Cytometry and Convolutional Neural Network-Based Classification Enable Discrimination of Hematopoietic and Leukemic Stem Cells in Acute Myeloid Leukemia. Int J Mol Sci. 2024 Jun.
Haldrup SH, Fabian-Jessing BK, Jakobsen TS, Lindholm AB, Adsersen RL, Aagaard L, Bek T, Askou AL, Corydon TJ. Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal model. Mol Ther Methods Clin Dec. 2024 Jun.
Rosenberg CA, Rodrigues MA, Bill M, Ludvigsen M. Comparative analysis of feature-based ML and CNN for binucleated erythroblast quantification in myelodysplastic syndrome patients using imaging flow cytometry data. Sci Rep. 2024 Apr.
Søgaard AB, Skovbo F, Tvilum A, Hansson RF, Zelikin AN. Artificial Internalizing Receptor Affords Fast, Potent, Specific Drug Delivery to the Chemically Engineered Cells. Advanced Functional Materials. 2024 Apr.
Cheetham M, Davies D, Hall C, Petersen CC, Schulte R, Walker R. Practicalities of Cell Sorting. Methods Mol Bio. 2024 Apr.
Zhang B, Laursen MF, Hu L, Hazrati H, Narita R, Jensen LS, Hansen AS, Huang J, Zhang Y, Ding X, Muyesier M, Nilsson E, Banasik A, Zeiler C, Mogensen TH, Etzerodt A, Agger R, Johannsen M, Kofod-Olsen E, Paludan SR, Jakobsen MR. Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds. Nat Commun. 2024 Mar.
van der Horst D, Kurmasheva N, Marqvorsen MHS, Assil S, Rahimic AHF, Kollmann CF, da Costa LS, Wu Q, Zhao J, Cesari E, Marie B Iversen MB, Ren F, Jensen TI, Narita R, Schack VR, Zhang B, Bak RO, Sette C, Fenton RA, Mikkelsen JG, Paludan SR, Olagnier D. SAM68 directs STING signaling to apoptosis in macrophages. Commun Biol. 2024 Mar.
Juul-Madsen K, Parbo P, Ismail R, Ovesen PL, Schmidt V, Madsen LS, Thyrsted J, Gierl S, Breum M, Larsen A, Andersen MN, Romero-Ramos M, Holm CK, Andersen GR, Zhao H, Schuck P, Nygaard JV, Sutherland DS, Eskildsen SF, Willnow TE, Brooks DJ, Vorup-Jensen T. Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment. Nat Commun. 2024 Feb.
Thomsen MM, Skouboe MK, Møhlenberg M, Zhao J, de Keukeleere K, Heinz JL, Werner M, Hollensen AK, Lønskov J, Nielsen I, Carter-Timofte ME, Zhang B, Mikkelsen JG, Fisker N, Paludan SR, Assing K, Mogensen TH. Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis. J Clin Immunol. 2024 Jan.
Terkelsen T, Mikkelsen NS, Bak EN, Vad-Nielsen J, Blechingberg J, Weiss S, Drue SO, Andersen H, Andresen BS, Bak RO, Jensen UB. CRISPR activation to characterize splice-altering variants in easily accessible cells. AJHG. 2024 Jan.
Maimaitili M, Chen M, Febbraro F, Ucuncu E, Kelly R, Niclis JC, Christiansen JR, Mermet-Joret N, Niculescu D, Lauritsen J, Iannielli A, Klæstrup IH, Jensen UB, Qvist P, Nabavi S, Broccoli V, Nykjær A, Romero-Ramos M, Denham M. Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells. Nature Communications. 2023 Dec.
Ferreira SA, Li C, Klæstrup IH, Vitic Z, Rasmussen RK, Kirkegaard A, Toft GU, Betzer C, Svendsen P, Jensen PH, Luo Y, Etzerodt A, Moestrup SK, Romero-Ramos M. Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s disease. npj Parkinson's Disease. 2023 Dec.
Andersen SH, Kjær TR, Ghimire K, Porpiglia E. Identification and Analysis of Myogenic Progenitors In Vivo During Acute Skeletal Muscle Injury by High-Dimensional Single-Cell Mass Cytometry. Biology. 2023 Dec.
Fazeli E, Child DD, Bucks SA, Stovarsky M, Edwards G, Rose SE, Yu CE, Latimer C, Kitago Y, Bird T, Jayadec S, Andersen OM, Young JE. A familial missense variant in the Alzheimer's Disease gene SORL1 impairs its maturation and endosomal sorting. bioRxic. 2023 Nov.
Wibrand C, Wittenborn TR, Voss LF, Winther G, Jensen L, Ferapontov A, Fonager SV, Fahlquist-Hagert C, Degn SE. B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus. Front. Immunol. 2023 Nov.
Ryø LB, Haslund D, Rovsing AB, Pihl R, Sanrattana W, de Maat S, Palarasah Y, Maas C, Thiel S, Mikkelsen JG. Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants. J Allergy Clin Immunol. 2023 Nov.
Haldrup J, Andersen S, Labial AFL, Wolff JH, Frandsen FP, Skov TW, Rovsing AB, Nielsen I, Jakobsen TS, Askou AL, Thomsen MK, Corydon TJ, Thomsen EA, Mikkelsen JG. Engineered lentivirus-derived nanoparticles (LVNPs) for delivery of CRISPR/Cas ribonucleoprotein complexes supporting base editing, prime editing and in vivo gene modification. Nucleic Acids Research. 2023 Oct.
Ghorbane S, Füchtbauer AC, Møllebjerg A, Martensen PM, Laursen SH, Kraft DCE, Kjems J, Meyer RL, Rahimi K, Foss M, Füchtbauer EM, Sutherland DS. Protein ligand and nanotopography separately drive the phenotype of mouse embryonic stem cells. Biomaterials. 2023 Oct.
Fahlquist-Hagert C, Wittenborn TR, Terczynska-Dyla E, Kastberg KS, Yang E, Rallistan AN, Markett QR, Winther G, Fonager S, Voss LF, Pedersen MK, Campen Nv, Ferapontov A, Jensen L, Huang J, Nieland JD, Poel CEvd, Palmfeldt J, Carrol MC, Utz PJ, Luo Y, Lin L, Degn SE. Antigen presentation by B cells enables epitope spreading across an MHC barrier. Nature Communications. 2023 Oct.
Barman SD, Frimand Z, Morree AD. Absolute Quantification of mRNA Isoforms in Adult Stem Cells Using Microfluidic Digital PCR. Bio Protoc. 2023 Sep.
Okholm TLH, Kamstrup AB, Nielsen MM, Hollensen AK, Graversgaard ML, Kristensen LS, Vang S, Park SS, Yeo GW, Dyrskjøt L, Kjems J, Pedersen JS, Damgaard CK. circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. bioRxiv. 2023 Sep.
Jespersen JH, Harazin A, Bohn AB, Christensen A, Lorentzen E, Lorentzen A. Analysis of cortical cell polarity by imaging flow cytometry. Journal of Cellular Biochemistry. 2023 Sep.
Tesson SVM, Barbarto M, Rosati B. Aerosolization flux, bio-products, and dispersal capacities in the freshwater microalga Limnomonas gaiensis (Chlorophyceae). Communications Biology. 2023 Aug.
Ren H, Narita R, Rashidi AS, Fruhwürth S, Gao Z, Bak RO, Thomsen MK, Verjans GM, Reinert LS, Paludan SR. ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2. EMBO J. 2023 Aug.
Hansen AS, Jensen LS, Gammelgaard KR, Ryttersgaard KG, Krapp C, Just J, Jønsson KL, Jensen PB, Boesen T, Johansen M, Etzerodt A, Deleuran BW, Jakobsen MR. T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy. J Extracell Vesicles. 2023 Aug.
Pedersen DV, Gytz H, Winkler MBL, Zarantonello A, Baumann N, Hansen AG, Thiel S, Andersen GR, Valerius T, Laursen NS. Bispecific Complement Engagers for Targeted Complement Activation. J Immunol. 2023 Aug.
Dorset SR, Daugaard TF, Larsen TV, Nielsen AL. RGMb impacts partial epithelial-mesenchymal transition and BMP2-Induced ID mRNA expression independent of PD-L2 in nonsmall cell lung cancer cells. Cell Biology International. 2023 July.
Jeyaseelan T, Romero-Ramos M, Petersen CP. Betrayal of the Markers. Cytometry A. 2023 Jul.
Neldeborg S, Soerensen JF, Møller CT, Bill M, Gao Z, Bak RO, Holm K, Sorensen B, Nyegaard M, Luo Y, Hokland P, Stougaard M, Ludvigsen M, Holm CK. Dual intron-targeted CRISPR-Cas9-mediated disruption of the AML RUNX1-RUNX1T1 fusion gene effectively inhibits proliferation and decreases tumor volume in vitro and in vivo. Leukemia. 2023 Jul.
Pedersen JM, Hansen AS, Skejø C, Juul-Madsen K, Junker P, Hørslev-Petersen K, Hetland ML, Stengaard-Pedersen K, Østergaard M, Møller BK, Dreyer L, Hauge EM, Hvid M, Greisen S, Deleuran B. Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis. Arthritis Research & Therapy. 2023 Jun.
Cecchi CR, Alsing S, Jesus GPP, Zacarias EA, Kjaer L, Clement MS, Kumagai-Braesch M, Corydon TJ, Bartolini P, Peroni CN, Aagaard L. Sustained secretion of human growth hormone from TheraCyte devices encapsulated with PiggyBac-engineered retinal pigment epithelium cells. Tissue and Cell. 2023 Jun.
Mikkelsen NS, Hernandez SS, Jensen TI, Schneller JL, Bak RO. Enrichment of transgene integrations by transient CRISPR activation of a silent reporter gene. Mol Ther Methods Clin Dev. 2023 Jun.
Tesson SVM. Physiological responses to pH in the freshwater microalga Limnomonas gaiensis. Journal of Basic Microbiology. 2023 May.
Larsen TV, Daugaard TF, Gad HH, Hartmann R, Nielsen AL. PD-L1 and PD-L2 immune checkpoint protein induction by type III interferon in non-small cell lung cancer cells. Immunobiology. 2023 May.
Zhao X, Qu K, Curci B, Yang H, Bolund L, Lin L, Luo Y. Comparison of In-Frame Deletion, Homology-Directed Repair, and Prime Editing-Based Correction of Duchenne Muscular Dystrophy Mutations. Biomolecules. 2023 May.
Rovsing AB, Thomsen EA, Nielsen I, Skov TW, Luo Y, Dybkær K, Mikkelsen JG. Resistance to vincristine in DLBCL by disruption of p53-induced cell cycle arrest and apoptosis mediated by KIF18B and USP28. British Journal of Haematology. 2023 May.
Billeskov TB, Jensen JB, Jessen N, Farup J. Fluorescence-activated cell sorting and phenotypic characterization of human fibro-adipogenic progenitors. STAR Protoc. 2023 Jan
Seeler S, Andersen MS, Sztanka-Toth T, Rybiczka-Tesulov M,Munkhof MHvd, Chang CC, Maimaitili M, Venø MT, Hansen TB, Pasterkamp RJ, Rybak-Wolf A, Denham M, Rajewsky N, Kristensen LS, Kjems J. A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development. Molecular Neurobiology. 2023 Feb.
Lauridsen KM, Hokland M, Al-Karradi S, Møller HJ, Donskov F, Andersen MN. Soluble CD163: a novel independent prognostic biomarker in patients with metastatic renal cell carcinoma. Cancer Immunol Immunother 2023 Feb.
Ferapontov A, Omer M, Baudrexel I, Nielsen JS, Dupont DM, Juul-Madsen K, Steen P, Eklund AS, Thiel S, Vorup-Jensen T, Jungmann R, Kjems J, Degn SE. Antigen footprint governs activation of the B cell receptorNat Commun. 2023 Feb.
Pedersen K, Nielsen MA, Juul-Madsen K, Hvid M, Deleuran B, Greisen SR. Galectin-3 interacts with PD-1 and counteracts the PD-1 pathway-driven regulation of T cell and osteoclast activity in Rheumatoid Arthritis. Scand J Immunol. 2023 Feb.
Nielsen MA, Køster D, Mehta AY, Stengaard-Pedersen K , Busson P, Junker P, Hørslev-Petersen K, Hetland ML, Østergaard M, Hvid M, Leffler H, Kragstrup TW, Cummings RD, Deleuran B. Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts. Cells 2023 Jan.
Nielsen MA, Køster D, Greisen S, Troldborg A, Stengaard-Pedersen K, Junker P, Hørslev-Petersen K, Hetland ML, Østergaard M, Hvid M, Leffler H, Kragstrup TW, Deleuran B. Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology. 2023 Jan.
Brandt CB, Fonager SV, Haskó J, Helmig RB, Degn S, Bolund L, Jessen N, Lin L, Luo Y. HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes. Biomolecules. 2023 Jan.
Voss LF, Howart A J, Wittenborn TR, Hummelgaard S, Juul-Madsen K, Kastberg KS, Pedersen MK, Jensen L, Papanastasiou AD, Vorup-Jensen T, Weyer K, Degn SE. The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus. Front. Immunol. 2022 Dec.
Frimand Z, Barman SD, Kjær T R, Porpiglia E, Morrée A d. Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles. Biology. 2022 Dec.
Ipsen MB, Sørensen EAG, Thomsen EA, Weiss S, Haldrup J, Dalby A, Palmfeldt J, Bross P, Rasmussen M, Fredsøe J, Klingenberg S, Jochumsen MR, Bouchelouche K, Ulhøi BP, Borre M, Mikkelsen JG, Sørensen KD. A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer. Oncogene 2022 Sep.
Andersen OM, Bøgh N, Landau AM, Pløen GG, Jensen AMG, Monti G, Ulhøi BP, Nyengaard JR, Jacobsen KR, Jørgensen MM, Holm IE, Kristensen ML, Alstrup AKO, Hansen ESS, Teunissen CE, Breidenbach L, Droescher M, Liu Y, Pedersen HS, Callesen H, Luo Y, Bolund L, Brooks DJ, Laustsen C, Small SA, Mikkelsen LF, Sørensen CB. A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency. Cell Rep Med 2022 Sep.
Jensen RK, Pedersen H, Lorentzen J, Laursen N S, Vorup-Jensen T, Andersen GR. Structural insights into the function-modulating effects of nanobody binding to the integrin receptor αMβ2. Journal of Biological Chemistry. 2022 Aug.
Jensen JB, Dollerup OL, Møller AB, Billeskob TB, Dalbram E, Chubanava S, Damgaard MV, Dellinger RW, Trošt K, Moritz T, Ringgaard S, Møller N, Treebak JT, Farup J, Jessen N. A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals. JCI Insight. 2022 Aug.
Thomsen EA, Skipper KA, Andersen S, Haslund D, Skov TS, Mikkelsen JG. CRISPR-Cas9-directed gene tagging using a single integrase-defective lentiviral vector carrying a transposase-based Cas9 off switch. Mol Ther Nucleic Acids 2022 Aug.
Dietz LL, Furman NT, Larsen TV, Daugaard TF, Thomsen EA, Keller JL, Aagaard L, Sorensen BS, Nielsen AL. An Extended PD-L2 Cytoplasmic Domain Results From Alternative Splicing in NSCLC Cells. J Immunother 2022 Aug.
Schack VR, Herlin MK, Pedersen H, Jensen JMB, Faerch M, Bundgaard B, Jensen RK, Jensen UB, Christensen R, Andersen GR, Thiel S, Höllsberg P. Novel homozygous CD46 variant with C-isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome. Eur J Immunol 2022 Aug.
Jensen RK, Pedersen H, Lorentzen J, Laursen NS, Vorup-Jensen T, Andersen GR. Structural insights into the function-modulating effects of nanobody binding to the integrin receptor αMβ2. J. Biol. Chem. 2022.
Fonager SV, Winther G, Wittenborn TR, Jensen L, Fahlquist-Hagert C, Hansen LA, Füchtbauer E, Romero-Ramos M, Degn SE. Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. J Neuroimmunol, 2022 Jul.
Petersen MA, Rosenberg CA, Bill M, Enemark MB, Rahbek O, Roug AS, Hasle H, Honoré B, Ludvigsen M. Proteomic Profiling Identifies Specific Leukemic Stem Cell-Associated Protein Expression Patterns in Pediatric AML Patients. Cancers (Basel) 2022 Jul.
Wang F, Ding P, Liang X, Ding X, Brandt C B, Sjöstedt E, Zhu J, Bolund S, Zhang L, Rooji L P M H d, Luo L, Wei Y, Zhao W, Lv Z, Haskó J, Li R, Qin Q, Jia Y, Wu W, Yuan Y, Pu M, Wang H, Wu A, Xie L, Lio P, Chen F, Herold J, Kalucka J, Karlsson M, Zhang X, Helmig R B, Fagerberg L, Lindskog C, Pontén F, Uhlen M, Bolund L, Jessen N, Jiang H, Xu X, Yang H, Carmeliet P, Mulder J, Chen D, Lin L, Luo Y. Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level. Nature Communications. 2022 Jun.
Skejoe C, Hansen AS, Stengaard-Pedersen K, Junker P, Hoerslev-Pedersen K, Hetland ML, Oestergaard M, Greisen S, Hvid M, Deleuran M, Deleuran B. T-cell immunoglobulin and mucin domain 3 is upregulated in rheumatoid arthritis, but insufficient in controlling inflammation. Am J Clin Immunol. 2022 Jun.
Nielsen MA, Juul-Madsen K, Stegmayr J, Gao C, Mehta AY, Greisen SR, Kragstrup TW, Hvid M, Vorup-Jensen T, Cummings RD, Leffler H, Deleuran BW. Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB. Front Immunol. 2022 Jun.
Asling S, Lindholm AB, Haldrup J, Jensen EG, Mikkelsen JG, Aagaard L, Askou AL, Corydon T. Simple Autofluorescence-Restrictive Sorting of eGFP+ RPE Cells Allows Reliable Assessment of Targeted Retinal Gene Therapy. Front. Drug Deliv. 2022 May.
Katzilieris-Petras G, Lai X, Rashidi AS, Verjans GM, Reinert LS, Paludan SR. Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice. Microbial Pathogenisis. 2022 Mar.
Greisen SR, Kragstrup TW, Thomsen J S, Hørselv-Pedersen K, Hetland ML, Stengaard-Pedersen K, Østergaard M, Ørnbjerg L, Junker P, Sharpe AH, Freeman GJ, Hvid M, Moestrup SK, Hauge EM, Deleuran B. The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental Settings. Front. Immunol. 2022 Mar.
Petersen MA, A Rosenberg C, F Brøndum R, Aggerholm A, Kjeldsen E, Rahbek O, Ludvigsen M, Hasle H, S Roug A, Bill M. Immunophenotypically defined stem cell subsets in paediatric AML are highly heterogeneous and demonstrate differences in BCL-2 expression by cytogenetic subgroups. BJHaem. 2022 Mar.
Nissen SK, Farmen K, Carstensen M, Schulte C, Goldeck D, Brockmann K, Romero-Ramos M. Changes in CD163+, CD11b+, and CCR2+ peripheral monocytes relate to Parkinson’s disease and cognition. Brain, Behavior, and Immunity. 2022 Mar.
Rossen LS, Schack VR, Thuesen KKH, Bundgaard B, Höllsberg P. D46 isoforms influence the mode of entry byhuman herpesvirus 6A/B in T cells. Journal of Virology. 2022 Mar.
van der Sluis RM, Cham LB, Gris-Oliver A, Gammelgaard KR, Pedersen JG, Idorn M, Ahmadov U, Hernandez SS, Cémalovic E, Godsk SH, Thyrsted J, Gunst JD, Nielsen SD, Jørgensen JJ, Bjerg TW, Laustsen A, Reinert LS, Olagnier D, Bak RO, Kjolby M, Holm CK, Tolstrup M, Paludan SR, Kristensen LS, Søgaard OS, Jakobsen MR. TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection. The Embo Journal. 2022 Mar.
Alsing S, Doktor TK, Askou AL, Jensen EG, Ahmadov U, Kristensen LS, Andresen BS, Aagaard L, Corydon TJ. VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy. Mol Ther Nucleic Acids. 2022 Feb.
Sørensen AS, Andersen MN, Juul-Madsen K, Broksø AD, Skejø C, Schmidt H, Vorup-Jensen T, Kragstrup TW. Tumor necrosis factor alpha neutralization attenuates immune checkpoint inhibitor-induced activation of intermediate monocytes in synovial fluid mononuclear cells from patients with inflammatory arthritis. Arthritis Research and Threapy. 2022 Feb.
Lima CN, Oliveira WF, Silva PMM, Filho PEC, Juul-Madsen K, Moura P, Vorup-Jensen T, Fontes A. Mannose-binding lectin conjugated to quantum dots as fluorescent nanotools for carbohydrate tracing. Methods and Applications in Fluorescence 2022 Feb.
Thomsen EA, Andersen S, Marqvorsen MHS, Skipper KA, Paludan SR, Mikkelsen JG. Single-Cell Monitoring of Activated Innate Immune Signaling by a d2eGFP-Based Reporter Mimicking Time-Restricted Activation of IFNB1 Expression. Front Cell Infect Microbiol. 2022 Jan.
Herold J, Kalucka J. A Rapid Adaptable Method for Isolation of Endothelial Cells from Human Adipose Tissue. Methods in Molecular Biology, 2022 Jan.
Rosenberg CA, Bill M, Rodrigues MA, Hauerslev M, Kerndrup GB, Hokland P, Ludvigsen M. Exploring dyserythropoiesis in patients with myelodysplastic syndrome by imaging flow cytometry and machine-learning assisted morphometrics. Cytometry B Clin Cytom. 2021 Dec.
Green K, Wittenborn TR, Fahlquist-Hagert C, Terczynska-Dyla E, van Campen N, Jensen L, Reinert L, Hartmann R, Paludan SR, Degn SE. B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. Front. Immunol. 2021 Dec.
Jensen TI, Mikkelsen NS, Gao Z, Fosselteder J, Pabst G, Axelgaard E, Laustsen A, König S, Reinisch A, Bak RO. Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi. Genome Res. 2021 Nov.
Staunstrup NH, Petersen CC, Fuglsang T, Starnawska A, Chernomorchenko A, Qvist P, Schack VR. Comparison of electrostatic and mechanical cell sorting with limited starting material. Cytometry A. 2021 Nov.
Pedersen JG, Egedal JH, Packard TA, Thavachelvam K, Xie G, van der Sluis RM, Greene WC, Roan NR, Jakobsen MR. Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C-C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status. Front Microbiol. 2021 Nov.
Thyrsted J, Storgaard J, Blay-Cadanet J, Heinz A, Thielke AL, Crotta S, de Paoli F, Olagnier D, Wack A, Hiller K, Hansen AL, Holm CK. Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium. iScience. 2021 Nov.
Køster D, Egedahl JH, Lomholt S, Hvid M, Jakobsen MR, Müller-Ladner U, Eibel H, Deleuran B, Kragstrup TW , Neumann E, Nielsen MA. Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis. Sci Rep. 2021 Nov.
Farup J, Just J, de Paoli F, Lin L, Brorson Jensen J, Billeskov T, Roman IS, Cömert C, Møller AB, Madaro L, Groppa E, Fred RG, Kampmann U, Gormsen LC, Pedersen SB, Bross P, Stevnsner T, Eldrup N, Pers TH, Rossi FMV, Puri PL, Jessen N. Human skeletal muscle CD90 + fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients. Cell Metab. 2021 Nov.
Carter-Timofte ME, Arulanandam R, Kurmesheva N, Fu K, Laroche G, Taha Z, van der Horst D, Cassin L, van der Sluis RM, Palermo E, Di Carlo D, Jacobs D, Maznyi G, Azad T, Singaravelu R, Ren F, Hansen AL, Idorn M, Holm CK, Jakobsen MR, van Grevenynghe J, Hiscott J, Paludan SR, Cell JC, Seguin J, Sabourin LA, Côté M, Diallo JS, Alain T, Olagnier D. Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern. ACS Infect Dis. 2021 Nov.
Rosenberg CA, Bill M, Maguire O, Petersen MA, Kjeldsen E, Hokland P, Ludvigsen M. Imaging flow cytometry reveals a subset of TdT negative T-ALL blasts with very low forward scatter on conventional flow cytometry. Cytometry B Clin Cytom. 2021 Oct.
Andersen NSB, Jørgensen SE, Skipper KA, Larsen SM, Heinz J, Thomsen MM, Farahani E, Cai Y, Hait AS, Kay L, Mikkelsen JG, Høgsbjerg Schleimann M, Thomsen MK, Paludan SR, Mogensen TH. Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. Autophagy. 2021 Sep.
Laustsen A, van der Sluis RM, Gris-Oliver A, Hernandez SS, Cemalovic E, Q Tang H, Pedersen LH, Uldbjerg N, Jakobsen MR, Bak RO. Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells. Elife. 2021 Sep.
Poulsen SB, Cheng L, Penton D, Kortenoeven MLA, Matchkov VV, Loffing H, Little R, Murali SK, Fenton RA. Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure. Kidney International. 2021 Aug.
Rittig AH, Johansen C, Celis P, Odum N, Litman T, Woetmann A, Lindahl LM, Iversen L. Suppressed microRNA-195-5p expression in mycosis fungoides promotes tumor cell proliferation. Exp Dermatol. 2021 Aug.
Lindgreen Eriksen L, Aagard Nielsen M, Lund Laursen T, Deleuran B, Vilstrup H, Støy S. Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis. PLoS One. 2021 Aug.
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Abildgaard A, Elfving B, Hokland M, Wegener G, Lund S. The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour.Arch Physiol Biochem. 2017 Nov
Callesen MM, Árnadóttir SS, Lyskjaer I, Ørntoft MW, Høyer S, Dagnaes-Hansen F, Liu Y, Li R, Callesen H, Rasmussen MH, Berthelsen MF, Thomsen MK, Schweiger PJ, Jensen KB, Laurberg S, Ørntoft TF, Elverløv-Jakobsen JE, Andersen CL. A genetically inducible porcine model of intestinal cancer. Mol Oncol. 2017 Nov
Christiansen SH, Murphy RA, Juul-Madsen K, Fredborg M, Hvam ML, Axelgaard E, Skovdal SM, Meyer RL, Sørensen UBS, Möller A, Nyengaard JR, Nørskov-Lauritsen N, Wang M, Gadjeva M, Howard KA, Davies JC, Petersen E, Vorup-Jensen T.The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.Sci Rep. 2017 Nov
Abildgaard A, Elfving B, Hokland M, Lund S, Wegener G.Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats. Brain Behav Immun. 2017 Oct
Šantl-Temkiv T, Amato P, Gosewinkel U, Thyrhaug R, Charton A, Chicot B, Finster K, Bratbak G, Löndahl J. High-Flow-Rate Impinger for the Study of Concentration, Viability, Metabolic Activity, and Ice-Nucleation Activity of Airborne Bacteria.Environ Sci Technol. 2017 Oct
Abildgaard A, Elfving B, Hokland M, Lund S, Wegener G. Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats.Brain Behav Immun. 2017 Oct
Ogunjimi B, Zhang SY, Sørensen KB, Skipper KA, Carter-Timofte M, Kerner G, Luecke S, Prabakaran T, Cai Y, Meester J, Bartholomeus E, Bolar NA, Vandeweyer G, Claes C, Sillis Y, Lorenzo L, Fiorenza RA, Boucherit S, Dielman C, Heynderickx S, Elias G, Kurotova A, Auwera AV, Verstraete L, Lagae L, Verhelst H, Jansen A, Ramet J, Suls A, Smits E, Ceulemans B, Van Laer L, Plat Wilson G, Kreth J, Picard C, Von Bernuth H, Fluss J, Chabrier S, Abel L, Mortier G, Fribourg S, Mikkelsen JG, Casanova JL, Paludan SR, Mogensen TH. Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. J Clin Invest. 2017 Sep 1
Christensen R, Owens DM, Füchtbauer AC, Gunnarsson A, Ramsing M, Füchtbauer EM, Jensen UB. Constitutive transgene expression of Stem Cell Antigen-1 in the hair follicle alters the sensitivity to tumor formation and progression. Stem Cell Res. 2017 Aug
Staunstrup NH, Stenderup K, Mortensen S, Primo MN, Rosada C, Steiniche T, Liu Y, Li R, Schmidt M, Purup S, Dagnæs-Hansen F, Schrøder LD, Svensson L, Petersen TK, Callesen H, Bolund L, Mikkelsen JG. Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1.Dis Model Mech. 2017 Jul
Greisen SR, Yan Y, Hansen AS, Venø MT, Nyengaard JR, Moestrup SK, Hvid M, Freeman GJ, Kjems J, Deleuran B. Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis.Front Immunol. 2017 Jul 24
Jensen KT, Fløe L, Petersen TS, Huang J, Xu F, Bolund L, Luo Y, Lin L. Chromatin accessibility and guide sequence secondary structure affect CRISPR-Cas9 gene editing efficiency.FEBS Lett. 2017 Jul;
Xiong K, Zhou Y, Blichfeld KA, Hyttel P, Bolund L, Freude KK, Luo Y. RNA-Guided Activation of Pluripotency Genes in Human Fibroblasts.Cell Reprogram. 2017 Jun
Hollensen AK, Thomsen R, Bak RO, Petersen CC, Ermegaard ER, Aagaard L, Damgaard CK, Mikkelsen JG. Improved microRNA suppression by WPRE-linked tough decoy microRNA sponges.RNA. 2017 Aug;23(8):1247-1258. doi: 10.1261/rna.061192.117. Epub 2017 May 9.
Johansen C, Rittig AH, Mose M, Bertelsen T, Weimar I, Nielsen J, Andersen T, Rasmussen TK, Deleuran B, Iversen L. STAT2 is involved in the pathogenesis of psoriasis by promoting CXCL11 and CCL5 production by keratinocytes. PLoS One. 2017 May 4
Heftdal LD, Andersen T, Jæhger D, Woetmann A, Østgård R, Kenngott EE, Syrbe U, Sieper J, Hvid M, Deleuran B, Kragstrup TW. Synovial cell production of IL-26 induces bone mineralization in spondyloarthritis..J Mol Med (Berl). 2017 Apr 2.
Jakobsen KR, Demuth C, Madsen AT, Hussmann D, Vad-Nielsen J, Nielsen AL, Sorensen BS. MET amplification and epithelial-to-mesenchymal transition exist as parallel resistance mechanisms in erlotinib-resistant, EGFR-mutated, NSCLC HCC827 cells. Oncogenesis. 2017 Apr 3
Lin L, Petersen TS, Jensen KT, Bolund L, Kühn R, Luo Y. Fusion of SpCas9 to E. coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells.J Biotechnol. 2017 Apr 10
Kristensen AM, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Höllsberg P, Deleuran B, Hvid M.Kristensen AM, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Höllsberg P, Deleuran B, Hvid M. Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-α therapy.Cytokine. 2017 Mar 3
Hussmann D, Madsen AT, Jakobsen KR, Luo Y, Sorensen BS, Nielsen AL.IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells.Oncotarget. 2017 Mar 18
Christiansen SH, Zhang X, Juul-Madsen K, Hvam ML, Vad BS, Behrens MA, Thygesen IL, Jalilian B, Pedersen JS, Howard KA, Otzen DE, Vorup-Jensen T. The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage.Biochim Biophys Acta. 2017 Mar
Jønsson KL, Laustsen A, Krapp C, Skipper KA, Thavachelvam K, Hotter D, Egedal JH, Kjolby M, Mohammadi P, Prabakaran T, Sørensen LK, Sun C, Jensen SB, Holm CK, Lebbink RJ, Johannsen M, Nyegaard M, Mikkelsen JG, Kirchhoff F, Paludan SR, Jakobsen MR.IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun. 2017 Feb
Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells.PLoS Pathog. 2017 Feb 16
Hansen AS, Bundgaard BB, Biltoft M, Rossen LS, Höllsberg P. Divergent tropism of HHV-6AGS and HHV-6BPL1 in T cells expressing different CD46 isoform patterns. Virology. 2017 Feb
Olesen MN, Christiansen JR, Petersen SV, Jensen PH, Paslawski W, Romero-Ramos M, Sanchez-Guajardo V.Heliyon CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology. 2018 Feb 1
Zhou Y, Al-Saaidi RA, Fernandez-Guerra P, Freude KK, Olsen RK, Jensen UB, Gregersen N, Hyttel P, Bolund L, Aagaard L, Bross P, Luo Y. Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency. Stem Cells Dev. 2017 Feb
Botha J, Velling Magnussen L, Nielsen MH, Nielsen TB, Højlund K, Andersen MS, Handberg A. Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels But Were Unaltered by Testosterone Therapy.J Diabetes Res. 2017
Christensen HL, Păunescu TG, Matchkov V, Barbuskaite D, Brown D, Damkier HH, Praetorius J.The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations. Physiol Rep. 2017 Jan
Gunnarsson AP, Christensen R, Praetorius J, Jensen UB. Isolating subpopulations of human epidermal basal cells based on polyclonal serum against trypsin-resistant CSPG4 epitopes. Exp Cell Res. 2017 Jan
Holzscheiter MH, Alsner J, Bassler N, Boll R, Caccia M, Knudsen H, Maggiore C, Petersen JB, Sellner S, Straße T, Singers Sørensen B, Overgaard J.The relative biological effectiveness of antiprotons. Radiother Oncol. 2016 Dec
Reinert LS, Lopušná K, Winther H, Sun C, Thomsen MK, Nandakumar R, Mogensen TH, Meyer M, Vægter C, Nyengaard JR, Fitzgerald KA, Paludan SR. Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. Nat Commun. 2016 Nov
Andersen MN, Al-Karradi SN, Kragstrup TW, Hokland M. Elimination of erroneous results in flow cytometry caused by antibody binding to Fc receptors on human monocytes and macrophages. Cytometry A. 2016 Nov
Vad-Nielsen J, Lin L, Bolund L, Nielsen AL, Luo Y. Golden Gate Assembly of CRISPR gRNA expression array for simultaneously targeting multiple genes. Cell Mol Life Sci. 2016 NovCell Mol Life Sci. 2016 Nov
Toft-Petersen M, Nederby L, Kjeldsen E, Kerndrup GB, Brown GD, Hokland P, Stidsholt Roug A. Unravelling the relevance of CLEC12A as a cancer stem cell marker in myelodysplastic syndrome. Br J Haematol. 2016 Nov
Hansen AS, Bundgaard BB, Møller BK, Höllsberg P. Non-random pairing of CD46 isoforms with skewing towards BC2 and C2 in activated and memory/effector T cells. Sci Rep. 2016 Oct 14
Nielsen MA, Andersen T, Etzerodt A, Kragstrup TW, Rasmussen TK, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Hvid M, Moestrup SK, Deleuran B. A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4-1BB activity and disease outcome in rheumatoid arthritis. Rheumatology (Oxford). 2016 Oct
Iversen MB, Gottfredsen RH, Larsen UG, Enghild JJ, Praetorius J, Borregaard N, Petersen SV.Extracellular superoxide dismutase is present in secretory vesicles of human neutrophils and released upon stimulation. Free Radic Biol Med. 2016 Aug
Rasmussen MH, Lyskjær I, Jersie-Christensen RR, Tarpgaard LS, Primdal-Bengtson B, Nielsen MM, Pedersen JS, Hansen TP, Hansen F, Olsen JV, Pfeiffer P, Ørntoft TF, Andersen CL. miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells. Nat Commun. 2016 Aug
Gunnarsson AP, Christensen R, Li J, Jensen UB. Dataset on gene expression profiling of multiple murine hair follicle populations. Data Brief. 2016 Sep
Tentillier N, Etzerodt A, Olesen MN, Rizalar FS, Jacobsen J, Bender D, Moestrup SK, Romero-Ramos M. Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model. J Neurosci. 2016 Sep 7
Jensen MR, Bajic G, Zhang X, Laustsen AK, Koldsø H, Skeby KK, Schiøtt B, Andersen GR, Vorup-Jensen T.Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.J Biol Chem. 2016 Aug
Callesen MM, Berthelsen MF, Lund S, Füchtbauer AC, Füchtbauer EM, Jakobsen JE.Recombinase-Mediated Cassette Exchange (RMCE)-in Reporter Cell Lines as an Alternative to the Flp-in System. PLoS One. 2016 Aug 19
Gunnarsson AP, Christensen R, Li J, Jensen UB. Global gene expression and comparison between multiple populations in the mouse epidermis. Stem Cell Res. 2016 Jul; 17(1):191-202
Zhou Y, Liu Y, Hussmann D, Brøgger P, Al-Saaidi RA, Tan S, Lin L, Petersen TS, Zhou GQ, Bross P, Aagaard L, Klein T, Rønn SG, Pedersen HD, Bolund L, Nielsen AL, Sørensen CB, Luo Y.Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system.Cell Mol Life Sci. 2016 Jul
Chotirat S, Suriyo T, Hokland M, Hokland P, Satayavivad J, Auewarakul CU. Cholinergic activation enhances retinoic acid-induced differentiation in the human NB-4 acute promyelocytic leukemia cell line. Blood Cells Mol Dis. 2016 Jul
Cai Y, Laustsen A, Zhou Y, Sun C, Anderson MV, Li S, Uldbjerg N, Luo Y, Jakobsen MR, Mikkelsen JG.Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors. Elife. 2016 Jun 9
Zhang X, Bajic G, Andersen GR, Christiansen SH, Vorup-Jensen T. The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis.Biochim Biophys Acta. 2016 May
Christiansen JR, Olesen MN, Otzen DE, Romero-Ramos M, Sanchez-Guajardo V. α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.J Neuroinflammation. 2016 Apr
Ranjbar B, Krogh LB, Laursen MB, Primo MN, Marques SC, Dybkær K, Mikkelsen JG. Anti-Apoptotic Effects of Lentiviral Vector Transduction Promote Increased Rituximab Tolerance in Cancerous B-Cells. PLoS One. 2016 Apr 5;11(4)
Marques SC, Ranjbar B, Laursen MB, Falgreen S, Bilgrau AE, Bødker JS, Jørgensen LK, Primo MN, Schmitz A, Ettrup MS, Johnsen HE, Bøgsted M, Mikkelsen JG, Dybkær K. High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma. Exp Hematol. 2016 Apr;44(4):238-46.
Kragstrup TW, Greisen SR, Nielsen MA, Rhodes C, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Hvid M, Vorup-Jensen T, Robinson WH, Sokolove J, Deleuran B.The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression.Arthritis Res Ther. 2016 Mar 11
Iversen MB, Reinert LS, Thomsen MK, Bagdonaite I, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev SY, Krzyzowska M, Kratholm SK, Ruiz-Perez F, Petersen SV, Goriely S, Bibby BM, Eriksson K, Ruland J, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR. An innate antiviral pathway acting before interferons at epithelial surfaces. Nat Immunol. 2016 Feb;17(2):150-8.
Hoedt A, Christensen B, Nellemann B, Mikkelsen UR, Hansen M, Schjerling P, Farup J.Satellite cell response to erythropoietin treatment and endurance training in healthy young men.J Physiol. 2016 Feb 1
Zhou Y, Liu Y, Hussmann D, Brøgger P, Al-Saaidi RA, Tan S, Lin L, Petersen TS, Zhou GQ, Bross P, Aagaard L, Klein T, Rønn SG, Pedersen HD, Bolund L, Nielsen AL, Sørensen CB, Luo Y. Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system. Cell Mol Life Sci. 2016 Jan 11.
Gong X, Garcia-Robledo E, Schramm A, Revsbech NP. Respiratory Kinetics of Marine Bacteria Exposed to Decreasing Oxygen Concentrations.Appl Environ Microbiol. 2015 Dec 18.
Nielsen TB, Nielsen MH, Handberg A. In vitro Incubation of Platelets with oxLDL Does Not Induce Microvesicle Release When Measured by Sensitive Flow Cytometry. Front Cardiovasc Med. 2015 Nov 30;2:37
Hoedt A, Christensen B, Nellemann B, Mikkelsen UR, Hansen M, Schjerling P, Farup J. Satellite cell response to erythropoietin treatment and endurance training in healthy young men. J Physiol. 2015 Nov 26.
Kang R, Zhou Y, Tan S, Zhou G, Aagaard L, Xie L, Bünger C, Bolund L, Luo Y. Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity. Stem Cell Res Ther. 2015 Aug 18;6:144.
Rasmussen TK, Andersen T, Bak RO, Yiu G, Sørensen CM, Stengaard-Pedersen K, Mikkelsen JG, Utz PJ, Holm CK, Deleuran B. Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus.Arthritis Res Ther. 2015 Jun 9;17:154
Andersen MN, Andersen NF, Rødgaard-Hansen S, Hokland M, Abildgaard N, Møller HJ. The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206): Implications in multiple myeloma.Leuk Res. 2015 Jun 10
Andersen RK, Hammer K, Hager H, Christensen JN, Ludvigsen M, Honoré B, Thomsen MB, Madsen M. Melanoma tumors frequently acquire LRP2/megalin expression, which modulates melanoma cell proliferation and survival rates. Pigment Cell Melanoma Res. 2015 May
Ørskov AD, Treppendahl MB, Skovbo A, Holm MS, Friis LS, Hokland M, Grønbæk K. Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients: A rationale for combined targeting of PD-1 and DNA methylation.Oncotarget. 2015 Apr
Marques SC, Ranjbar B, Laursen MB, Falgreen S, Bilgrau AE, Bødker JS, Jørgensen LK, Primo MN, Schmitz A, Ettrup MS, Johnsen HE, Bøgsted M, Mikkelsen JG, Dybkær K. High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma. Exp Hematol. 2016 Apr
Nederby L, Roug AS, Knudsen SS, Skovbo A, Kjeldsen E, Moller HJ, Hokland M. Soluble CD163 as a prognostic biomarker in B-cell chronic lymphocytic leukemia. Leuk Lymphoma. 2015 Mar 28:1-3.
Iversen MB, Jensen SK, Hansen AL, Winther H, Issazadeh-Navikas S, Reinert LS, Holm CK. NKT cell activation by local α-galactosylceramide administration decreases susceptibility to HSV-2 infection. Immunobiology. 2015 Jan 21
Askou AL, Aagaard L, Kostic C, Arsenijevic Y, Hollensen AK, Bek T, Jensen TG, Mikkelsen JG, Corydon TJ. Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors. Mol Ther Methods Clin Dev. 2015 Jan 28;2:14064.
Pløen GG, Nederby L, Guldberg P, Hansen M, Ebbesen LH, Jensen UB, Hokland P, Aggerholm A. Persistence of DNMT3A mutations at long-term remission in adult patients with AML. Br J Haematol. 2014 Nov;167(4):478-86.
Laustsen JK, Rasmussen TK, Stengaard-Pedersen K, Hørslev-Petersen K, Hetland ML, Østergaard M, Junker P, Hvid M, Deleuran B. Soluble OX40L is associated with presence of autoantibodies in early rheumatoid arthritis. Arthritis Res Ther. 2014 Oct 30
Roy A, Tesauro C, Frøhlich R, Hede MS, Nielsen MJ, Kjeldsen E, Bonven B, Stougaard M, Gromova I, Knudsen BR.:Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I.
PLoS One. 2014 Jun 24
Vanthournout B, Deswarte K, Hammad H, Bilde T, Lambrecht B, Hendrickx F.:Flow cytometric sexing of spider sperm reveals an equal sperm production ratio in a female-biased species.
Biol Lett. 2014 May
Gottfredsen RH, Goldstrohm DA, Hartney JM, Larsen UG, Bowler RP, Petersen SV.: The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the naturally occurring R213G substitution.
Free Radic Biol Med. 2014 Apr
Rölfing JH, Baatrup A, Stiehler M, Jensen J, Lysdahl H, Bünger C. The osteogenic effect of erythropoietin on human mesenchymal stromal cells is dose-dependent and involves non-hematopoietic receptors and multiple intracellular signaling pathways. Stem Cell Rev. 2014 Feb;10(1):69-78
Nielsen MH, Beck-Nielsen H, Andersen MN, Handberg A.:A flow cytometric method for characterization of circulating cell-derived microparticles in plasma.J Extracell Vesicles. 2014 Feb
van Kooten Niekerk PB, Petersen CC, Nyvold CG, Ommen HB, Roug AS, Nederby L, Hokland P, Kjeldsen E.:Cell sorting enables interphase fluorescence in situ hybridization detection of low BCR-ABL1 producing stem cells in chronic myeloid leukaemia patients beyond deep molecular remission.Br J Haematol. 2014 Jan
Kratholm SK, Iversen MB, Reinert L, Jensen SK, Hokland M, Andersen T, Rankin A, Young D, Frische S, Paludan SR, Holm CK.: Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections. PLoS One. 2013 Dec 16
Rölfing JH, Baatrup A, Stiehler M, Jensen J, Lysdahl H, Bünger C.:The Osteogenic Effect of Erythropoietin on Human Mesenchymal Stromal Cells is Dose-Dependent and Involves Non-Hematopoietic Receptors and Multiple Intracellular Signaling Pathways. Stem Cell Rev. 2013 Sep 20
Mogensen TH, Bernt-Jensen JM, Petersen CC, Petersen MS, Nyvold C, Gadegaard CH, Hokland M, Hokland P, Larsen CS: Common variable immunodefiency unmasked by treatment of immune trombocytopenic purpura with Rituximab. BMC Hematology 2013, 13:4
Muhammad U. Cheema, Ebbe T Poulsen, Jan J. Enghild, Ewout Hoorn, Robert A. Fenton, Jeppe Praetorius: Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules. Physiol.Rep, 1(4),2013, e00064.
Jiang X, Foldbjerg R, Miclaus T, Wang L, Singh R, Hayashi Y, Sutherland D, Chen C, Autrup H, Beer C.: Multi-platform genotoxicity analysis of silver nanoparticles in the model cell line CHO-K1. Toxicol Lett. 2013 Sep 12;222(1):55-63.
Jakobsen JE, Johansen MG, Schmidt M, Dagnæs-Hansen F, Dam K, Gunnarsson A, Liu Y, Kragh PM, Li R, Holm IE, Callesen H, Mikkelsen JG, Nielsen AL, Jørgensen AL.:Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT). Transgenic Res. 2013 Aug;22(4):709-23. doi: 10.1007/s11248-012-9671-6. Epub 2012 Oct 31.
Zou L, Luo Y, Chen M, Wang G, Ding M, Petersen CC, Kang R, Dagnaes-Hansen F, Zeng Y, Lv N, Ma Q, Le DQ, Besenbacher F, Bolund L, Jensen TG, Kjems J, Pu WT, Bünger C.: A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. Sci Rep. 2013 Jul 22;3:2243
Sundvall L, Lund H, Niemann I, Jensen UB, Bolund L, Sunde L.Tetraploidy in hydatidiform moles. Hum Reprod. 2013 Jul;28(7):2010-20
Brinkmann CR, Jensen L, Dagnæs-Hansen F, Holm IE, Endo Y, Fujita T, Thiel S, Jensenius JC, Degn SE. Mitochondria and the lectin pathway of complement. J Biol Chem. 2013 Mar 22;288(12)
Tørring C, Pedersen CC, Bjerg L, Kofod-Olsen E, Petersen T, Höllsberg Per:The B1-cell subpopulation is diminished in patients with relapsing-remitting multiple sclerosis.. Jounal of Neuroimmunology 2013; JNI-475734
Kjaer TR, Hansen AG, Sørensen UBS, Holm AT, Sørensen GL, Jensenius JC, Thiel S: M-ficolin binds selectively to the capsular polysaccharides of Streptococcus pneumoniae serotypes 19B and 19C and of a Streptococcus mitis strain.: Infection and Immunity 2013(81-2): 452-459
Niekerk PBvK, Roug AS, Petersen CC, Ommen HB, Kjeldsen E, Bendix K, Nyvold CG, Nederby L, Hokland P:Chronic myeloid leukaemia presenting with isolated thrombocythaemia, a case revealing its stem cell biology.British Jounal of Haematology, 2013, 162,130-144
Lassen LB, Füchtbauer A, Schmitz A, Sørensen AB, Pedersen FS, Füchtbauer EM: Septin9 is involved in T-cell development and CD8+ T-cell homeostasis..Cell Tissue Res (2013) 352:695-705
Sharma N, Cai Y, Bak RO, Jakobsen MR, Schrøder LD, Mikkelsen JG.: Efficient sleeping beauty DNA transposition from DNA minicircles.Mol Ther Nucleic Acids. 2013 Feb 26;2:e74
Jensen TB, Pisitkun T, Hoffert JD, Jensen UB, Fenton RA, Praetorius HA, Knepper MA, Praetorius J:Assessment of the effect of 24-hour aldosterone administration on protein abundance in fluorescence-sorted mouse distal renal tubules by mass spectrometry.. Nephron Physiol 2012; 121:p9-p15
Sharma N, Hollesen AK, Bak RO, Staunstrup NH, Schrøder LD,Mikkelsen JG: The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells.. PLoS One 2012(7);10,e48421
Etzerodt A, Maniecki MB, Graversen JH, Møller HJ, Torchilin VP, Moestrup SK.Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163. J Control Release. 2012 May 30;160(1):72-80
Reinert LS, Harder L, Holm CK, Iversen MB, Horan KA, Dagnæs-Hansen F, Ulhøi BP, Holm TH, Mogensen TH, Owens T, Nyengaard JR, Thomsen AR, and Paludan SR:TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice. J Clin Invest 2012: 122(4): 1368-76
Petersen CC: Opregulering af CD69 på T-celler som mulig tidlig markør for reaktivering af human cytomegalovirus. Best Practice Hæmatologi 2012(3): 28-30
Eskelund CW, Nederby L, Thysen AH, Skovbo A, Roug AS, Hokland ME: Interleukin-21 and rituximab enhance NK cell functionality in patients with B-cell chronic lymphocytic leukaemia. Leuk Res. 2011 Jul;35(7):914-20
Bohn AB, Nederby L, Harbo T, Skovbo A, Vorup-Jensen T, Krog J, Jakobsen J, Hokland ME: The effect of IgG levels on the number of natural killer cells and their Fc receptors in chronic inflammatory demyelinating polyradiculoneuropathy.Eur J Neurol. 2011 Jun;18(6):919-24.
Petersen CC, Nederby L, Roug AS, Skovbo A, Peterslund NA, Hokland P, Nielsen B, Hokland M.: Increased expression of CD69 on T cells as an early immune marker for human cytomegalovirus reactivation in chronic lymphocytic leukemia patients. Viral Immunol. 2011 Apr;24(2):165-9.
Christensen R, Owens DM, Thomsen A, Pedersen S, Jensen UB: Zinc fixation for flow cytometry analysis of intracellular and surface epitopes, DNA content, and cell proliferation.n. Current Protocols in Cytometry 2011: 7.40.1 - 7.40.9