The goal is to improve diagnostic strategies for complex conditions by using theranostics, which link diagnostics with personalized treatments.
Theranostics involves using diagnostic tests or markers to identify patients who are most likely to benefit or be harmed by specific treatments. We aim to integrate these methods to connect diagnostics directly with personalized treatment plans, considering condition variability, individual context, and the broader implications of diagnostic practices.
The goal here is to shift toward more comprehensive diagnostic models within the designated timeframe.
The ultimate objective is to move beyond reductionist treatment approaches for complex conditions.
Current research often simplifies these conditions, looking for a "silver bullet" treatment by focusing on one mechanism. While this works for simpler conditions, it is less effective for the complex diseases in TRANSCEND.
Instead, we aim to focus on the interaction between the condition and the individual, incorporating a broader view that considers contextual factors, condition variability, and the philosophical aspects of precision medicine, including how premorbid factors interact with disease components.
This work package includes work performed by doctoral candidates at the University of Oslo primarily supervised by Victor Greiff, at Aarhus University with Klaus Eyer, at the Università Vita-Salute San Raffaele with Daniela Latorre with secondments and interactions throughout the network and associated partners.
The work package involves collaboration between neuroscientists and philosophers of biology to promote critical discussion on experimental design and translation, as well as dissemination of insights from these practices to wider academic and non-academic audiences.