Publications

Sort by: Date | Author | Title

Geurts, F., Gritter, M., Bovée, D. M., Wouda, R. D., Vogt, L., Chaker, L., Fenton, R. A. & Hoorn, E. J. (2025). Association of Urinary Prostaglandin E2 with Plasma Potassium in Patients with Chronic Kidney Disease and the General Population. Clinical Journal of the American Society of Nephrology. Advance online publication. https://doi.org/10.2215/CJN.0000000653

Poulsen, S. B., Murali, S. K., Thomas, L., Assmus, A., Rosenbæk, L. L., Nielsen, R., Dimke, H., Rieg, T. & Fenton, R. A. (2025). Genetic deletion of the kidney sodium/proton exchanger-3 (NHE3) does not alter calcium and phosphate balance due to compensatory responses. Kidney International, 107(2), 280-295. https://doi.org/10.1016/j.kint.2024.07.013

Blanco, G., Xue, J., Thomas, L., Dominguez Rieg, J. A., Sun, D., Assmus, A., Fenton, R. A. & Rieg, T. (2025). Lack of renal NHE1 exacerbates lithium-induced nephrogenic diabetes insipidus. Acta Physiologica (Print), 241(4), e70029. Article e70029. https://doi.org/10.1111/apha.70029

Wu, A., Wolley, M. J., Vesey, D., Terker, A. S., Welling, P. A., Fenton, R. A. & Stowasser, M. (2025). Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease. Nephrology, 30(3), Article e70017. https://doi.org/10.1111/nep.70017

Liu, L., Rosenbaek, L. L., Kui, M., Svendsen, S. L., Brethvad, A. O., Jakobsen, A., Sparsoe, L. V., Hamilton, A., Sørensen, M. V., Skov, M., Therkildsen, J. R., Andresen, J. K., Laitakari, A., Frimurer, T. M., Jensen, B. L., Pluznick, J., Fenton, R. A., Holst, B. & Praetorius, H. (2025). Renal Ghrelin-Family GPR39 Receptor and Urinary Concentrating Ability. Journal of the American Society of Nephrology : JASN. Advance online publication. https://doi.org/10.1681/ASN.0000000687

D'Acierno, M., Fenton, R. A. & Hoorn, E. J. (2025). The biology of water homeostasis. Nephrology Dialysis Transplantation, 40(4), 632-640. https://doi.org/10.1093/ndt/gfae235

Beckmann, S. B., Salib, M., Fenton, R. A. & Hoorn, E. J. (2025). Toward Assessment of Tubular Function in Kidney Disease. Journal of the American Society of Nephrology : JASN, Article 10.1681/ASN.0000000705. Advance online publication. https://doi.org/10.1681/ASN.0000000705

Geurts, F., van Heugten, M. H., Blijdorp, C. J., Fenton, R. A., Chaker, L. & Hoorn, E. J. (2025). Urinary EGF Reflects Distal Tubular Mass and Is Associated with Hypertension, Serum Magnesium, and Kidney Outcomes. Kidney360, 6(3), 451-460. https://doi.org/10.34067/KID.0000000687

Fenton, R. A. & Ellison, D. H. (2024). 2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section. American journal of physiology. Renal physiology, 326(5), F855-F856. https://doi.org/10.1152/ajprenal.00086.2024

Fenton, R. A. (2024). Editorial: aquaporins in health and disease. Journal of Physiology, 602(13), 3003-3005. https://doi.org/10.1113/JP286369

Brooks, H. L., de Castro Brás, L. E., Brunt, K. R., Sylvester, M. A., Parvatiyar, M. S., Sirish, P., Bansal, S. S., Sule, R., Eadie, A. L., Knepper, M. A., Fenton, R. A., Lindsey, M. L., DeLeon-Pennell, K. Y. & Gomes, A. V. (2024). Guidelines on antibody use in physiology research. American journal of physiology. Renal physiology, 326(3), F511-F533. https://doi.org/10.1152/ajprenal.00347.2023

Esteva-Font, C., Geurts, F., Hansen, T. P. K., Hoorn, E. J. & Fenton, R. A. (2024). Inducible deletion of the prostaglandin EP3 receptor in kidney tubules of male and female mice has no major effect on water homeostasis. American Journal of Physiology: Renal Physiology, 327(3), F504-F518. https://doi.org/10.1152/ajprenal.00146.2024

Mikkelsen, J. H., Stødkilde, K., Jensen, M. P., Hansen, A. G., Wu, Q., Lorentzen, J., Graversen, J. H., Andersen, G. R., Fenton, R. A., Etzerodt, A., Thiel, S. & Andersen, C. B. F. (2024). Trypanosoma brucei Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis. Journal of Immunology, 212(8), 1334-1344. https://doi.org/10.4049/jimmunol.2300862

Billing, A. M., Kim, Y. C., Gullaksen, S., Schrage, B., Raabe, J., Hutzfeldt, A., Demir, F., Kovalenko, E., Lassé, M., Dugourd, A., Fallegger, R., Klampe, B., Jaegers, J., Li, Q., Kravtsova, O., Crespo-Masip, M., Palermo, A., Fenton, R. A., Hoxha, E. ... Rinschen, M. M. (2024). Metabolic Communication by SGLT2 Inhibition. Circulation, 149(11), 860-884. https://doi.org/10.1161/CIRCULATIONAHA.123.065517

Welling, P. A., Little, R., Al-Qusairi, L., Delpire, E., Ellison, D. H., Fenton, R. A. & Grimm, P. R. (2024). Potassium-Switch Signaling Pathway Dictates Acute Blood Pressure Response to Dietary Potassium. Hypertension, 81(5), 1044-1054. https://doi.org/10.1161/HYPERTENSIONAHA.123.22546

Murali, S. K., McCormick, J. A. & Fenton, R. A. (2024). Regulation of the water channel aquaporin-2 by cullin E3 ubiquitin ligases. American Journal of Physiology: Renal Physiology, 326(5), F814-F826. https://doi.org/10.1152/ajprenal.00049.2024

van der Horst, D., Kurmasheva, N., Marqvorsen, M. H. S., Assil, S., Rahimic, A. H. F., Kollmann, C. F., Silva da Costa, L., Wu, Q., Zhao, J., Cesari, E., Iversen, M. B., Ren, F., Jensen, T. I., Narita, R., Schack, V. R., Zhang, B.-C., Bak, R. O., Sette, C., Fenton, R. A. ... Olagnier, D. (2024). SAM68 directs STING signaling to apoptosis in macrophages. Communications Biology, 7, 283. Article 283. https://doi.org/10.1038/s42003-024-05969-1

Geurts, F., Rudolphi, C. F., Pelouto, A., Van Der Burgh, A. C., Salih, M., Imenez Silva, P. H., Fenton, R. A., Chaker, L. & Hoorn, E. J. (2024). The Effect of Thiazide Diuretics on Urinary Prostaglandin E2 Excretion and Serum Sodium in the General Population. The Journal of Clinical Endocrinology & Metabolism, 109(10), 2444-2451. https://doi.org/10.1210/clinem/dgae352

Harboe, M., Kjaer-Sorensen, K., Füchtbauer, E. M., Fenton, R. A., Thomsen, J. S., Brüel, A. & Oxvig, C. (2024). The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization. Scientific Reports, 14, Article 20161. https://doi.org/10.1038/s41598-024-71062-6

Geurts, F., Chaker, L., van der Burgh, A. C., Cronin-Fenton, D., Fenton, R. A. & Hoorn, E. J. (2024). Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease. Journal of the American Heart Association, 13(4), Article e032835. https://doi.org/10.1161/JAHA.123.032835

Fenton, R. A. (2024). Working Less Is the Key to Greater Scientific Productivity. Physiologist, 2024, 40-41.

Grimm, P. R., Tatomir, A., Rosenbaek, L. L., Kim, B. Y., Li, D., Delpire, E. J., Fenton, R. A. & Welling, P. A. (2023). Dietary potassium stimulates Ppp1Ca-Ppp1r1a dephosphorylation of kidney NaCl co-transporter and reduces blood pressure. Journal of Clinical Investigation, 133(21), Article e158498. https://doi.org/10.1172/JCI158498

Little, R., Murali, S. K., Poulsen, S. B., Grimm, P. R., Assmus, A., Cheng, L., Ivy, J. R., Hoorn, E. J., Matchkov, V., Welling, P. A. & Fenton, R. A. (2023). Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation. JCI Insight, 8(5), Article e156437. https://doi.org/10.1172/jci.insight.156437

Pluznick, J. L. & Fenton, R. A. (2023). Perspective on G protein-coupled receptors in renal physiology. American Journal of Physiology - Renal Physiology, 325(6), F683-F684. https://doi.org/10.1152/ajprenal.00307.2023

Geurts, F., Xue, L., Kramers, B. J., Zietse, R., Gansevoort, R. T., Fenton, R. A., Meijer, E., Salih, M., Hoorn, E. J. & DIPAK Consortium (2023). Prostaglandin E2, Osmoregulation, and Disease Progression in Autosomal Dominant Polycystic Kidney Disease. Clinical Journal of the American Society of Nephrology, 18(11), 1426-1434. https://doi.org/10.2215/CJN.0000000000000269

Wu, A., Wolley, M. J., Mayr, H. L., Cheng, L., Cowley, D., Li, B., Campbell, K. L., Terker, A. S., Ellison, D. H., Welling, P. A., Fenton, R. A. & Stowasser, M. (2023). Randomized Trial on the Effect of Oral Potassium Chloride Supplementation on the Thiazide-Sensitive Sodium Chloride Cotransporter in Healthy Adults. Kidney International Reports, 8(6), 1201-1212. https://doi.org/10.1016/j.ekir.2023.03.011

Wu, A., Wolley, M. J., Wu, Q., Cowley, D., Palmfeldt, J., Welling, P. A., Fenton, R. A. & Stowasser, M. (2022). Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles. Kidney360, 3(5), 910-921. https://doi.org/10.34067/KID.0000362022

Yde, J., Wu, Q., Borg, J. F., Fenton, R. A. & Moeller, H. B. (2022). A systems-level analysis of bile acids effects on rat colon epithelial cells. American Journal of Physiology - Gastrointestinal and Liver Physiology, 322(1), G34-G48. https://doi.org/10.1152/ajpgi.00178.2021

Deen, P. M. T., Boone, M., Schweer, H., Olesen, E. T. B., Carmone, C., Wetzels, J. F. M., Fenton, R. A. & Kortenoeven, M. L. A. (2022). A Vasopressin-Induced Change in Prostaglandin Receptor Subtype Expression Explains the Differential Effect of PGE₂on AQP2 Expression. Frontiers in Physiology, 12, Article 787598. https://doi.org/10.3389/fphys.2021.787598

Edemir, B., Petrillo, F., Chernyakov, D. & Fenton, R. (2022). Comprehensive analysis of NFAT5 associated gene expression in the renal collecting duct. The FASEB Journal, 36(S1). https://doi.org/10.1096/fasebj.2022.36.S1.0R507

Neumann, C., Rosenbaek, L. L., Flygaard, R. K., Habeck, M., Karlsen, J. L., Wang, Y., Lindorff-Larsen, K., Gad, H. H., Hartmann, R., Lyons, J. A., Fenton, R. A. & Nissen, P. (2022). Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity. The EMBO Journal, 41(23), Article e110169. https://doi.org/10.15252/embj.2021110169

Kristensen, M., Fenton, R. A. & Poulsen, S. B. (2022). Dissecting the Effects of Aldosterone and Hypokalemia on the Epithelial Na+ Channel and the NaCl Cotransporter. Frontiers in Physiology, 13, Article 800055. https://doi.org/10.3389/fphys.2022.800055

Xue, J., Thomas, L., Murali, S. K., Levi, M., Fenton, R. A., Dominguez Rieg, J. A. & Rieg, T. (2022). Enhanced phosphate absorption in intestinal epithelial cell-specific NHE3 knockout mice. Acta Physiologica (Print), 234(2), Article e13756. https://doi.org/10.1111/apha.13756

Xue, J., Thomas, L., Fenton, R. A., Dominguez Rieg, J. A. & Rieg, T. (2022). Generation and characterization of thick ascending limb specific knockout of NHE3 mouse model. The FASEB Journal, 36(S1). https://doi.org/10.1096/fasebj.2022.36.S1.R4942

Petrillo, F., Chernyakov, D., Esteva Font, C., Poulsen, S. B., Edemir, B. & Fenton, R. A. (2022). Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus. FASEB Journal, 36(11), Article e22583. https://doi.org/10.1096/fj.202200856R

Schepelmann, M., Ranieri, M., Lopez-Fernandez, I., Webberley, T. S., Brennan, S. C., Yarova, P. L., Graca, J., Hanif, U.-K., Müller, C., Manhardt, T., Salzmann, M., Quasnichka, H., Price, S. A., Ward, D. T., Gilbert, T., Matchkov, V. V., Fenton, R. A., Herberger, A., Hwong, J. ... Riccardi, D. (2022). Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells. Journal of the American Society of Nephrology : JASN, 33(7), 1323-1340. https://doi.org/10.1681/ASN.2021040585

Jepsen, M. R., Østergaard, J. A., Conover, C. A., Wogensen, L., Birn, H., Krag, S. P., Fenton, R. A. & Oxvig, C. (2022). Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy. Metabolism: Clinical and Experimental, 132, Article 155218. https://doi.org/10.1016/j.metabol.2022.155218

Wu, A., Wolley, M. J., Matthews, A., Cowley, D., Welling, P. A., Fenton, R. A. & Stowasser, M. (2022). In Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter. Kidney360, 3(11), 1909-1923. https://doi.org/10.34067/KID.0003632022

Reusch, B., Bartram, M. P., Dafinger, C., Palacio-Escat, N., Wenzel, A., Fenton, R. A., Saez-Rodriguez, J., Schermer, B., Benzing, T., Altmüller, J., Beck, B. B. & Rinschen, M. M. (2022). MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells. Journal of Proteomics, 252, Article 104424. https://doi.org/10.1016/j.jprot.2021.104424

Xue, J., Thomas, L., Dominguez Rieg, J. A., Fenton, R. A. & Rieg, T. (2022). NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification. American journal of physiology. Renal physiology, 323(2), F141-F155. https://doi.org/10.1152/ajprenal.00013.2022

Murali, S. K., Little, R., Poulsen, S. B., Ferdaus, M. Z., Ellison, D. H., McCormick, J. A. & Fenton, R. A. (2022). Potassium Effects on NCC Are Attenuated during Inhibition of Cullin E3-Ubiquitin Ligases. Cells, 11(1), Article 95. https://doi.org/10.3390/cells11010095

McDonough, A. A. & Fenton, R. A. (2022). Potassium homeostasis: sensors, mediators, and targets. Pflügers Archiv - European Journal of Physiology, 474(8), 853-867. https://doi.org/10.1007/s00424-022-02718-3

Grønkjær, C., Apolito, L. D., Rej, S., Fenton, R., Trepiccione, F. & Christensen, B. M. (2022). Proteomic analysis of urinary exosomes from patients with lithium-induced nephrogenic diabetes insipidus. The FASEB Journal, 36(S1). https://doi.org/10.1096/fasebj.2022.36.S1.0R585

Rosenbaek, L., Petrillo, F., Van Bemmelen, M., Staub, O., Murali, S. & Fenton, R. (2022). The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter (NCC) but is not required for a potassium-induced reduction of NCC expression. The FASEB Journal, 36(S1). https://doi.org/10.1096/fasebj.2022.36.S1.0R831

Rosenbaek, L. L., Petrillo, F., van Bemmelen, M. X., Staub, O., Murali, S. K. & Fenton, R. A. (2022). The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter NCC but is not required for a potassium-induced reduction of NCC expression. Frontiers in Physiology, 13, Article 971251. https://doi.org/10.3389/fphys.2022.971251

Chernyakov, D., Fischer, A., Brandau, M., Petrillo, F., Fenton, R. A. & Edemir, B. (2022). The nuclear factor of activated T cells 5 (NFAT5) contributes to the renal corticomedullary differences in gene expression. Scientific Reports, 12(1), Article 20304. https://doi.org/10.1038/s41598-022-24237-y

Van Heugten, M. H., Hoorn, E. J. & Fenton, R. A. (2022). Urinary extracellular vesicles: does cargo reflect tissue? Current Opinion in Nephrology and Hypertension, 31(5), 464-470. https://doi.org/10.1097/MNH.0000000000000822

Wu, A., Wolley, M. J., Fenton, R. A. & Stowasser, M. (2022). Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter. Frontiers in Endocrinology, 13, Article 981317. https://doi.org/10.3389/fendo.2022.981317

Poulsen, S. B., Cheng, L., Penton, D., Kortenoeven, M. L. A., Matchkov, V. V., Loffing, J., Little, R., Murali, S. K. & Fenton, R. A. (2021). Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure. Kidney International, 100(2), 321-335. https://doi.org/10.1016/j.kint.2021.04.021

Moser, S., Sugano, Y., Wengi, A., Fisi, V., Lindtoft Rosenbaek, L., Mariniello, M., Loffing-Cueni, D., McCormick, J. A., Fenton, R. A. & Loffing, J. (2021). A five amino acids deletion in NKCC2 of C57BL/6 mice affects analysis of NKCC2 phosphorylation but does not impact kidney function. Acta Physiologica (Print), 233(1), Article e13705. https://doi.org/10.1111/apha.13705

Displaying results 1 to 50 out of 233

Revised 27.10.2023

Lena Kjær Rosenbæk

Department of Biomedicine

Fenton lab

Publications