Manry, J., Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Michailidis, E., Hoffmann, H. H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., de Prost, N., Tandjaoui-Lambiotte, Y. ... CoV-Contact Cohort (2022).
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
Proceedings of the National Academy of Sciences (PNAS),
119(21), Article e2200413119.
https://doi.org/10.1073/pnas.2200413119
Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Manry, J., Michailidis, E., Hoffmann, H. H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., Prost, N. D., Tandjaoui-Lambiotte, Y. ... Imagine COVID Group (2021).
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Science Immunology,
6(62), Article 4340.
https://doi.org/10.1126/sciimmunol.abl4340
Arkin, L. M., Moon, J. J., Tran, J. M., Asgari, S., O'Farrelly, C., Casanova, J. L., Cowen, E. W., Mays, J. W., Singh, A. M., Drolet, B. A. & COVID Human Genetic Effort (2021).
From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.
Journal of Investigative Dermatology,
141(12), 2791-2796.
https://doi.org/10.1016/j.jid.2021.05.024