Abstract

Macrophages populate all human tissues where they serve an essential function in innate immunity and tissue homeostasis. However, a growing body of clinical and experimental evidence also suggest that disease-associated macrophages play key roles in disease progression in a large number of illnesses.

In the Macrophage Biology lab, we have a particular interest in the distinct functions of tissue-resident macrophages and macrophages recruited as part of disease progression, especially in the context of tumor development.

In this talk, I will present our recent work on identifying distinct subsets of tumor-associated macrophages (TAM) that have unique pro-tumoral functions and show how specific targeting of only tumor-promoting TAM subsets, may offer significant clinical benefits in a range of malignancies. In addition, I will give an introduction to current ongoing projects, with a particular emphasis on how we use antibody-targeted lipid nanoparticles to specific modulate the function of individual macrophage subsets.

 ABOUT THE SPEAKER

Anders Etzerodt is an Associate Professor at the Department of Biomedicine and heads the Macrophage Biology lab.

The talk is 45 minutes followed by 15 minutes of discussion, for a total of 1 hr. 

Biomedicine seminar organizing committee
Mikkel Vendelbo
Line Reinert
Søren Egedal Degn 
Martin Kristian Thomsen