Metabolism

Metabolic studies can be performed by various means, and equipment can often be combined and tailored to suit your exact needs - whether for long-term studies or intermittent repeated measurements.

Need help?

Send an email to phenotyping@biomed.au.dk 

and we will get back to you as soon as possible.


HM-2 metabolic cages

Applications in brief

HM-2 systems are advanced metabolic cages with more measurement features compared to Tecniplast metabolic cages and may be used for longer protocols, ranging from effects of drug absorption to obesity and diabetes.

Each animal is identified and monitored using its subcutaneously implanted RFID chip (requires anesthesia). The chip ensures identification of the animal as well as registration of drinking and feeding frequencies, duration, and amounts. Food and water can be manipulated, if needed.

Data is collected in the HM02Lab software, and although animals have to be weighed manually, data is logged to the same datafile/-base.

HM-2 systems can also be combined with e.g. telemetric observation of blood pressure, biopotentials and activity.

Features

For monitoring of

  • food and/or water intake
  • drinking and/or feeding frequencies, duration and amounts
  • feces collection
  • urine collection

Cages can be combined with other measurement techniques such as telemetry.

Location

HM-2 cages are normally located in the Skou building animal facility, please familiarize yourself with guidelines and regulations regarding animals as well as user quarantine regulations.

Tips and Tricks

How many animals can be housed in each cage?

  • 6-8 mice can be housed in each HM-2 cage.

How many cages are available?

  • There are currently 4 HM-2 cages available, allowing simultaneous monitoring of up to 32 mice.

Specifications

Full equipment name HM-2 system, MBRose
Specifications Overview on HM-2 system
Software HM02Lab software
Chip subcutaneous RFID chip

Booking

HM-2 cages

  • book the equipment in the Outlook calendar, 1115-K43D HM-2 cages
  • for general information on booking procedures, go to Booking

Tecniplast metabolic cages

Applications in brief

Tecniplast metabolic cages can be used for registration of nutrient consumption by collecting and separating urine and faeces, e.g. for studies ranging from effects of drug absorption to obesity and diabetes.

Features

For monitoring of

  • food intake
  • water intake
  • feces collection
  • urine collection

Cages can be combined with other measurement techniques such as telemetry for observaton of e.g. blood pressure, biopotentials and activity.

Location

Tecniplast metabolic cages are normally located in the Skou building animal facility, please familiarize yourself with guidelines and regulations regarding animals as well as user quarantine regulations.

Training and Manual

Tecniplast metabolic cage user guide

Booking

Tecniplast metabolic cages


Body composition analysis (EchoMRI)

Applications in brief

EchoMRI provides precise body composition measurements in awake animals. Body composition data include fat percentage, lean body mass, free water and total water mass, and can be obtained from mice. The scanning is fast, requiring only about 1-2 minutes, and can be repeated an unlimited number of times.

Features

For measurement of body masses of

  • fat
  • lean
  • free water
  • total water

Which species may I investigate?

  • mice

Location

EchoMRI is located in the Skou building animal facility, please familiarize yourself with guidelines and regulations regarding animals as well as user quarantine regulations.

Tips and Tricks

How many animals can I analyse at a time?

  • 1 mouse at a time

May I use a mouse with an implanted metal device or RFID chip?

  • No, EchoMRI cannot be used for mice with implanted metal devices or RFID chips. Please plan your experiments carefully, if you would like to combine EchoMRI with e.g. HM-2 metabolic monitoring.

Booking

Body composition analysis (EchoMRI)

  • book the equipment in the Outlook calendar, 1115-K43B Tail cuff/MRI
  • for general information on booking procedures, go to Booking