Osmotic pumps

Implantable pumps come in a number of varieties, but one of the most commonly used is the Alzet osmotic pump. Osmotic pumps offer a great opportunity for continuous administration of compounds, without needing repeated injection or handling of animals. Pumps are preloaded with the wanted compound or solution, with doses according to animal size. The concentration of the solution needs to be calculated from the pump’s fixed dose/delivery rate and total duration of administration, for the desired final dose to be correct. The pump size determines the loading volume, but also which duration of administration that is possible. Pumps are inserted subcutaneously in the scapular region or intraperitoneally, depending on animal and the size of the pump. Aqueous solutions, dilute acids and bases, dilute/low concentrations of DMSO and ethanol are all compatible with Alzet pumps. Animals need anesthesia for the insertion.

The researcher has to supply pumps and the wanted compound/solution. We will advise on dosing and choice of pump, if needed.

Vascular access button

Instech's vascular access buttons (VABs^TM) allow for repeated injections or sampling. The button is insered subcutaneously and connected to one or more catheters that are inserted into the wanted vessel(s). The button and aluminimum cap ensure a closed system, preventing evaporation, improving patency, and allowing aseptic conditions. The cap is magnetic and stays in place so that animals can be co-housed. The button connects to PinPorts, which have standard luer connectors. Implantation requires anesthesia, but sampling can be done on alert animals afterwards. The repeated use of the button can be done with less stress than with conventional handling, and the buttons are part of the Be Nice products, developed with the 3Rs in mind.