Research Leaders

Professors

We pursue causes and mechanisms related to autoimmune diseases, with a central focus on rheumatoid arthritis and connective tissue diseases like SLE. It is our aim to improve the understanding of basal mechanisms, leading to solutions that will offer precision health and not only precision medicine.

Our lab investigates the mechanisms by which human herpesvirus (HHV)-6A and HHV-6B enter and reprogram immune cells and cells of the nervous system. This may shed light on the pathogenesis of neurological diseases, such as multiple sclerosis and Alzheimer’s disease.
See also hollsberglab.au.dk

My lab studies the processes creating inflammation in the body, resulting from infections, autoimmune diseases and damages after surgeries. I focus on the role of pattern recognition molecules, which can differentiate between the body's normal proteins, and the pattern of ligands on the surface of a number of micro-organisms or stressed cells.

We investigate the function of macrophages, macrophage polarization and role of macrophage scavenger receptors acute/chronic inflammatory conditions including in the tumour immune-microenvironment. One major goal of our group is to transform our findings into novel therapeutic strategies.


We are interested in understanding how the innate immune system senses infections and sterile damage and how this impacts disease pathogenesis. To achieve this goal we use a broad range of methods ranging from molecular biology and molecular genetics, via cell culture systems to animal models.
See also paludanlab.dk.  

We investigate molecular mechanisms in chronic inflammation and autoimmune diseases to understand and design new biological therapies. Our interests also include antimicrobial peptides with a view to develop new antibiotics from drug repurposing to counter resistance to classic antibiotics.


Our research goal is to gain knowledge on the genetic and immunological basis of viral infections in humans. We perform genome sequencing on DNA from patients, followed by immunological characterization of patient cells. This leads to a new understanding of molecular mechanisms underlying primary immunodeficiencies and increased susceptibility to infectious diseases.

Associate Professors

Our research group studies structural and functional aspects of receptors involved in infection and inflammation. Current projects focus on the human haemoglobin scavenger receptor CD163 and the S. aureus iron-regulated surface determinant system.



Infection of the airways of the lung leads to a powerful inflammatory response, which impairs their ability to exchange CO2 and O2 effectively, as this is highly dependent on the integrity of the delicate anatomical structures. Our vision is to identify factors and signalling pathways that are important for limiting inflammation induced pathology in the lung during infection.

Our team investigates the role of human skin bacteria. Major projects are: (I) discovery and investigation of bacterial species associated with hospital-acquired and implant-associated infections; (II) mechanistic understanding of the role of bacteria in skin disorders and skin health.
See also: www.medbac.dk.


We study the pathogenesis of Chlamydia infections. As an obligate intracellular parasite, Chlamydia metabolically reprograms host cells to deplete the tumor suppressor TP53, pre-disposing them to a tumor-micro environment. My group focuses on the infection-cancer interface and investigates how the pathogen evades the immune system.

CNS inflammation is a common hallmark in several CNS diseases. We investigate the role of protective immune reactions and harmful inflammatory responses by studying interactions between glial cells and neurons in their organization of antiviral responses, inflammation, and cell death.


My group works on the functional characterization and biological impact of myeloid derived elements of the innate immune system in relation to malignancy. Moreover, our research interests are closely associated with the FACS core facility, developing new flow cytometry based applications for immune monitoring.

Immunosurveillance is an essential function of the immune system to protect the body against bacteria and viruses. It participates in controlling self-host damage responses and development of cancer and autoimmune diseases. We explore questions in context of viral infections, inflammation and cancer, from both a basic science and clinical translational angle.

The main aim of my research group is to study cancer in advanced animal models by use of CRISPR technology. For this, we use a mini-pig expressing Cas9 and a similar mouse model. The cancer is induced by AAV expressing CRISPR guides. We are currently focusing on glioblastoma, prostate and lung cancer in these models.

We study mechanisms promoting the dissemination of melanoma cancer. Focus is the characterization of key membrane receptors, endolysosomal compartments and central signalling pathways at different differentiation stages. In connection with this, we study melanoma communication and cooperativity with immune cells.

Oxidation of proteins can regulate biological processes (oxidative eustress) but also support the development of disease (oxidative distress). Our research aims to understand how oxidative capacity is controlled in the extracellular space with special focus on the inflammatory response.
Read more at redoxlab.au.dk


Translational research: pathogenesis of Multiple Sclerosis (MS) and NeuroMyelitis Optica Spectrum Disorders (NMOSD): neurodegeneration and inflammation; biomarkers; immune cell subsets; epigenetic regulation; involvement of Human Endogenous Retroviruses (HERVs) and HERV-related pathogenesis.

Our research is focused on immune mediated inflammatory diseases with special interest in arthritis. Based on unique human ex vivo models of arthritis projects include both very basic research studies trying to identify new pathogenic mechanisms and translational studies of biomarkers and drug pharmacodynamics.

The focus for my research is the two bacterial species pneumococci (Streptococcus pneumoniae) and group B streptococci (Streptococcus agalactaie). Our main topics are investigation of mutual interactions between host and bacteria, phylogenetic analysis of bacterial populations, examination of bacterial ultrastructure, methods for typing of bacteria, and analyses of bacterial polysaccharides. 

Assistant Professors

Our research focuses on understanding the function of distinct macrophage subsets in progression of cancer and chronic inflammatory conditions. To realize this, we utilize a wide range of methods, including single cell transcriptomics, whole tissue imaging, antibody-drug targeting and murine models.


The infectivity of several pathogenic bacteria is tightly associated with biofilm formation mediating resistance to host immune response and antibiotics. The structural component of biofilms is functional bacterial amyloids (FuBA). Our research activities are focused on understanding the molecular mechanisms involved in the formation of FuBA.

We focus on the role of B and T lymphocytes in health and disease, with a particular emphasis on tolerance and autoimmunity. Lymphocytes display the remarkable abilities of ‘learning’ and ‘memory’. We investigate these phenomena in mouse models using molecular tools, cytometry and microscopy.