Membranes surround all cells. Defective membrane function leads to disorders such as hypertension, migraine, and muscle weakness. We want to understand how membrane function is controlled and how their dysfunction links to disease.
We study how membrane-spanning proteins, in the form of receptors and transport proteins, collect and exchange information from their surroundings and thereby regulate cellular processes of critical importance. Examples are transport proteins controlling cerebrospinal fluid secretion, receptors that sense nutrients in the intestine, and channels that control muscle movement.
Our theme hosts more than 25 groups who collaborate with clinicians and the pharmaceutical sector.
How are cells produced and arranged in space and time to execute a defined task at cell level and cooperatively achieve a biological outcome at organ level?
What role do the small blood vessels play in serious neurological disorders?