We investigate mechanisms underlying memory formation, mood regulation and psychiatric disorders, with particular emphasis on sortilin receptors. Methods include molecular and cellular biology, transgenic mice, electrophysiology, behavior, and advanced imaging.
See also Nykjær group at dandrite.au.dk
We study, using genetic mouse models and circuit manipulations, the effects of stress on memory circuits. Our long-term goal is to identify targets for novel therapies of memory deficits induced by stress, which range from uncontrollable and intrusive memories to memories that are inaccessible to retrieval.
See also: Radulovic Lab
I am interested in the circuit and cellular mechanisms of emotion affecting behavior. In particular, I try to resolve how emotion changes hippocampal functions. To address this, I identify and dissect the emotional circuits using in vitro electrophysiology and behavioral analysis and combining these with opto/ chemogenetics tools.
We use animal models and human derived-samples to better understand the early changes in alpha-synuclein related neurodegeneration and the associated neuroinflammatory process during Parkinson’s Disease; With an ultimate focus on defining new targets and novel biomarkers. See also www.cns.au.dk
We are currently interested in understanding the mechanisms behind initiation and spreading of epileptic seizure activity in cortical networks and the dynamic properties of axonal propagation. We use various electrophysiological and histochemical techniques and various in vitro animal model systems.
We study the role of SORL1 as a sorting receptor for neuronal cargo molecules, to determine how SORL1 activity protects against Alzheimer’s disease using cell biology and animal models. We also focus on understanding regulation of SORL1 expression and to delineate its physiological function in the CNS.
We are currently interested in understanding the mechanisms behind initiation and spreading of epileptic seizure activity in cortical networks and the dynamic properties of axonal propagation. We use various electrophysiological and histochemical techniques and various in vitro animal model systems.
Our research is aimed at understanding systems-level molecular mechanisms of selective retention of trivial memory through neuromodulation in the hippocampus. Further, we study the assimilation of this retained memory into the relevant knowledge structure using e.g. sophisticated behavioural tests in rats.