Research Leaders

Professors

We investigate mechanisms underlying memory formation, mood regulation and psychiatric disorders, with particular emphasis on sortilin receptors. Methods include molecular and cellular biology, transgenic mice,  electrophysiology, behavior, and advanced imaging.
See also Nykjær group at dandrite.au.dk

We define neuronal circuits of human and rodent cerebral cortex, amygdala and hippocampus, as they underlie cognition and memory in health and disease. We focus on GABAergic neurons because of their critical role on networks. We use electrophysiology, pharmacology, optogenetic, imaging and anatomy.

Our nervous system including the brain and peripheral nerves permeate all regions of our body and is the basis for our mind. We want to understand its fundamental mechanisms and how dysfunctions contribute to diseases.



Associate Professors

Diseases and injuries affecting peripheral sensory nerves often result in severe neuropathic pain (NP) and disability, and underlie substantial socio-economical costs. My research aims to identify novel disease modifying strategies by manipulating glia-neuron interactions for the treatment of NP.

The Yonehara group investigates how spatial asymmetry in the neuronal circuits arises during development and support neural computation in adults. We address these questions mainly by focusing on visual circuits across retina, superior colliculus, thalamus, and visual cortex of mice.


In our team we are investigating what regulates synaptic plasticity and transmission in the brain. Especially, how can we possibly control it? We study key proteins involved in the underlying mechanisms using electrophysiology, pharmacological and genetic tools, combined with rodent disease models. 

We use animal models and human derived-samples to better understand the early changes in alpha-synuclein related neurodegeneration and the associated neuroinflammatory process during Parkinson’s Disease; With an ultimate focus on defining new targets and novel biomarkers. See also www.cns.au.dk 

We use human pluripotent stem cells to model Parkinson’s disease and to study how the nervous system develops. We differentiate patient-derived induced pluripotent stem cells into neurons and apply multiomic strategies to identify disease-modifying genes that may contribute to disease severity.  

We are currently interested in understanding the mechanisms behind initiation and spreading of epileptic seizure activity in cortical networks and the dynamic properties of axonal propagation. We use various electrophysiological and histochemical techniques and various in vitro animal model systems.

We focus on receptor mediated drug delivery to the brain. Using complex in-vitro Blood-Brain Barrier models based on primary cells and human stem cells, different sorting receptors are analyzed for its ability and capacity to transcytose drug into the brain.


I am interested in understanding the cellular mechanism underlying memory formation (synaptic plasticity) and how memory is affected by neurological diseases. My laboratory works on disease models (Alzheimer, ischemia) using in vitro electrophysiology, pharmacology, histology and animal behavior.

We study the role of SORL1 as a sorting receptor for neuronal cargo molecules, to determine how SORL1 activity protects against Alzheimer’s disease using cell biology and animal models. We also focus on understanding regulation of SORL1 expression and to delineate its physiological function in the CNS. 

Our group studies molecular mechanisms underlying neurological and metabolic disorders. We are interested in sorting receptors of the LDL receptor family and sortilin family, and how they regulate cellular processes. We employ a wide range of techniques in genetics, molecular, and cell biology.

We are currently interested in understanding the mechanisms behind initiation and spreading of epileptic seizure activity in cortical networks and the dynamic properties of axonal propagation. We use various electrophysiological and histochemical techniques and various in vitro animal model systems.