Membranes surround all cells. Defective membrane function leads to disorders such as hypertension, migraine, and muscle weakness. We want to understand how membrane function is controlled and how their dysfunction links to disease.
We study how membrane-spanning proteins, in the form of receptors and transport proteins, collect and exchange information from their surroundings and thereby regulate cellular processes of critical importance. Examples are transport proteins controlling cerebrospinal fluid secretion, receptors that sense nutrients in the intestine, and channels that control muscle movement.
Our theme hosts more than 25 groups who collaborate with clinicians and the pharmaceutical sector.
The molecular origins and pathways associated with the development and progression of human cardiac and skeletal myopathies.
How can we clarify cellular mechanisms and use the knowledge to treat certain eye- and kidney diseases?