UNDINE

KU Leuven boasts a rich tradition of education and research that dates back six centuries. The university’s basic research orientation has always been and will remain fundamental research. At the same time, the university remains vigilantly open to contemporary cultural, economic and industrial realities, as well as to the community’s needs and expectations. From a basis of social responsibility and scientific expertise, KU Leuven provides high-quality, comprehensive health care, including specialised tertiary care, in its University Hospitals. In doing so it strives towards optimum accessibility and respect for all patients.

The Laboratory of Inborn Errors of Immunity focuses on the study of genetically determined immunodeficiencies/inborn errors of immunity. Together with the clinical unit of Pediatric Immunodeficiencies, it was chosen as the first Belgian JMF Diagnostic and Research Center for Primary Immunodeficiencies in 2011.

Our main research domains are:
•    clinical, genetic and immunological study of life-threatening infections, including COVID19
•    molecular and biological mechanisms of the human antimicrobial response
•    monogenic auto-inflammatory disorders, in particular ADA2 deficiency. Research on ADA2 deficiency is supported by a European Research Council (ERC) starting grant and a Research Foundation - Flanders (FWO) research grant.
•    hematopoietic stem cell transplantation for inborn errors of immunity
•    inborn errors of immunity in general

Within UNDINE, we will lead work package 1 and contribute to WP6.

Laboratory of Inborn Errors of Immunity: https://gbiomed.kuleuven.be/english/research/50000698/50546724/index.html